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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Respirasi (JR) Jurnal Ilmiah Kesehatan Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology International Journal of Social Service and Research Jurnal Ilmiah Kesehatan (JIKA) Jurnal Widya Medika
Rebekah Setiabudi, Rebekah
Clinical Microbiology Specialist Program, Faculty Of Medicine, Universitas Airlangga − Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Folia Medica Indonesiana

 1 
Bacterial and Antibiogram Profile of Urinary Tract Infection Patients in a Tertiary Hospital, Surabaya, Indonesia Mahrumi Dewi Tri Utami; Manik Retno Wahyunitisari; Nunuk Mardiana; Rebekah Juniati Setiabudi
Folia Medica Indonesiana Vol. 58 No. 3 (2022): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1180.165 KB) | DOI: 10.20473/fmi.v58i3.33186

Abstract

Highlights: Most urinary tract infections are caused by Gram-negative bacteria with E. coli being the most common bacteria. Antibiotics with the highest susceptibility for Gram-negative bacteria were ertapenem, meropenem, amikacin, and imipenem. Antibiotics with the highest susceptibility for Gram-positive bacteria mainly were susceptible to chloramphenicol,streptomycin, vancomycin, rifampin, tigecycline,  teicoplanin, and ampicillin.   Abstract: Urinary tract infection (UTI) is one of the most common bacterial infections. Inappropriate antibiotic use for UTI treatment may lead to antibiotic resistance. This study aimed to provide an updated bacterial and antibiogram profile from urine specimens of patients diagnosed with UTI. This study was a retrospective study using urine culture and antibiotic susceptibility test results obtained from Clinical Microbiology Laboratory in a tertiary general hospital in Surabaya, Indonesia for a two-month period patients. Most aged more than and/or equal to 59 years, in both sexes. Gram-negative bacteria, particularly , was being the most between June to July 2019. There were 215 patients with significant urine culture results of 54.4% from Escherichia coli female bacteria were carbapenem antibiotics and amikacin, while teicoplanin and vancomycin were some antibiotics susceptible to gramcommon bacteria that caused UTI, followed by K. pneumoniae. Some antibiotics with the highest susceptibility to gram-negative positive bacteria. This study result indicated that there was an urge to conduct local antibiogram profile investigation due to the low susceptibilities shown in recent empirical therapy recommendations, such as trimethoprim sulfamethoxazole, fluoroquinolone, nitrofurantoin, and fosfomycin.
Antifungal Activity of Selaginella plana (Desv. ex Poir.) Hieron Extract Against Candida albicans In Vitro Juen Carla Warella; Khairunnida Rahma; Agung Dwi Wahyu Widodo; Rebekah Juniati Setiabudi
Folia Medica Indonesiana Vol. 59 No. 3 (2023): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v59i3.44165

Abstract

Highlights: 1. A study on the medical benefits of Selaginella plana has significant academic value due to its extensive traditional usage among the Moluccan people as a medicinal remedy, especially for its antifungal properties.2. The findings of this study will allow further screening to determine the mechanism of action of bioactive compounds in inhibiting the growth of Candida albicans   Abstract Candidiasis is an opportunistic infection caused by Candida albicans. This infection commonly affects the skin, oral mucosa, vagina, and gastrointestinal tract. Excessive use of azole antifungals in the treatment of Candida albicans infections can lead to the development of resistance. Therefore, it is necessary to explore alternative treatments using medicinal plants such as Selaginella plana, commonly referred to as “rutu-rutu” in a local language spoken across Maluku, Indonesia. Selaginella plana contains active compounds belonging to various chemical classes, including terpenoids, steroids, flavonoids, and saponins. This study aimed to determine the ability of Selaginella plana extract as an antifungal agent against Candida albicans by evaluating its inhibitory and antifungal effects. This study used an actual experimental design and broth dilution method. The research methodology involved the extraction of Selaginella plana using a solvent of 96% ethanol. The extract was then prepared in various concentrations, i.e., 100%, 50%, 25%, 12.5%, 6.25%, and 3.125%. Additionally, ketoconazole and distilled water were included in the experiment for the positive and negative controls, respectively. The results of this study demonstrated that Selaginella plana extract inhibited the growth of Candida albicans when administered starting at a concentration of 12.5%. However, the antifungal potential of Selaginella plana extract that induced cell death was only observed at a concentration of 100%. The fungicidal activity was exclusively identified in the undiluted, pure extract. The inhibitory and cytotoxic effects of Selaginella plana on Candida albicans cells were attributed to the presence of bioactive compounds in Selaginella plana, including flavonoids, tannins, terpenoids, and saponins. These bioactive compounds had the ability to inhibit cell growth by altering membrane permeability, causing mitochondrial dysfunction, and disrupting ergosterol biosynthesis. It can be concluded that Selaginella plana extract can act as a fungistatic agent against the proliferation of Candida albicans.
Co-Authors Achmad Ardianto Adhima, Fauziah Afif Hidayati Agung Dwi Wahyu Widodo Alimsardjono, Lindawati Anindita Rehana Arina Setyaningtyas Awalia Ayu Rahmanita Putri Soetrisno Ayurveda Zaynabila Heriqbaldi Azzahra, Safira Deby Kusumaningrum Dewi Setyowati Diah Mira Indramaya Didik Didik Handijatmo, Didik Dwiyanti Puspitasari, Dwiyanti Eko Budi Koendhori, Eko Budi Evy Ervianti Farah Meriana Fajrin Hammam Izza Rofiqi Hasan, Helmia Indiastuti, Danti Nur Juniastuti Juniastuti Khairunnida Rahma Laksmi Wulandari M. Kharis Khamdan M. Yulianto Listiawan Mahrumi Dewi Tri Utami Manik R Wahyunitisari ManikRetno Wahyunitisari Mariska Nuriana Marsha Zahrani Maya Wardiana Neurinda Permata Kusumastuti Ni Made Mertaniasih Nunuk Mardiana, Nunuk Pepy Dwi Endraswari, Pepy Dwi Prasanti, Siva Allysha Purwanto, Satiti Palupi Putri S Wulandari Rafly Bayu Surya Wardhana Rahmadewi Rahmadewi Rehana, Anindita Resti Yudhawati Retno Asih Setyoningrum Risky Vitria Prasetyo Rochmanti, Maftuchah Rochmanti Rossyanti, Lynda Sawitri Sawitri Silvia Sutandhio Sri Ratna Dwiningshih Suhintam Pusarawati Sulistiawati Sulistiawati Sulistiawati Sulistiawati Titiek Sulistyowati Utami Meilanie Putri Wahyunitisari, Manik Retno Wardhany, Atiqah Nurul Warella, Juen Carla Yuri Widia, Yuri