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All Journal Jurnal Ilmu Kesehatan Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) JMM (Jurnal Masyarakat Mandiri) Indonesian Journal of Cardiology Heart Science Journal Narra J Jurnal Neuroanestesi Indonesia Narra X Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Teuku Heriansyah, Teuku
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Other

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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

 1 
Relationship between the Left Atrial Volume Index and Left Ventricular Geometry and the Incidence of Atrial Fibrillation in Hypertensive Patients with Cardiovascular Complications Djeni, Chairatu Sadrina; Heriansyah, Teuku; Mudatsir; Novita; Munirwan, Haris
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.12031

Abstract

This study aimed to evaluate the relationships of the left atrial volume index (LAVI) and left ventricular geometry with the incidence of AF in hypertensive patients with cardiovascular complications such as heart failure or coronary arterial disease.  This study employed a retrospective observational cohort design. A total of 202 subjects met the inclusion and exclusion criteria for the study. The subjects were selected from hypertensive patients with cardiovascular complications treated at Dr. Zainoel Abidin General Hospital Banda Aceh, a tertiary referral center in Indonesia, between July and December 2024. 12At the end of the study, the participants were divided into two groups: those with newly diagnosed atrial fibrillation (n=37) and those without atrial fibrillation (n=165). The diagnosis of new-onset atrial fibrillation was based on medical records obtained during hospitalization and continued through a three-month follow-up after discharge via outpatient clinic visits and 12-lead ECG monitoring. The study revealed a significant association between increased LAVI and AF incidence (p < 0.01). The mean LAVI in the AF group was 49.9 ± 19.2 ml/m², whereas it was 33.34 ± 15.6 ml/m² in the non-AF group. Additionally, changes in left ventricular geometry were correlated with increased AF incidence (p value = 0.03), with eccentric hypertrophy showing the highest AF incidence (29.5%). A strong association was also found between increased LAVI and left ventricular geometric changes, with eccentric hypertrophy resulting in the highest mean LAVI (43.2 ± 16.9 ml/m²). The odds ratio (OR) analysis demonstrated that patients with LAVI above the threshold had a significantly greater risk of developing AF (OR: 5.2; 95% CI: 2.475–11.161). Similarly, patients with normal ventricular geometry had a significantly lower risk of AF compared to those with eccentric hypertrophy (OR: 0.148; 95% CI: 0.049–0.449). Increased LAVI and left ventricular geometry changes, particularly eccentric hypertrophy, are significant risk factors for AF in hypertensive patients with cardiovascular complications such as heart failure and coronary arterial disease. Clinical practice should incorporate echocardiographic monitoring of left ventricular geometry and LAVI to prevent the progression of AF and detect risk early
ARNI vs ACE Inhibitors in Improving Left Ventricular Geometry, Diastolic Function, and Cardiac Power Output in HFrEF Patients: A Prospective Cohort Study among Acehnese, Indonesia Taufiqurrahman; Heriansyah, Teuku; Purnawarman, Adi; Novita; Zulkarnain
Jurnal Penelitian Pendidikan IPA Vol 11 No 4 (2025): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i4.10593

Abstract

Heart failure with reduced ejection fraction (HFrEF) is a condition associated with high morbidity and mortality. Changes in left ventricular geometry, diastolic function, and cardiac power output (CPO) are key indicators in the management of heart failure. ARNI and ACE inhibitors have been proven effective to treat this condition, but comparative studies on these therapies in the Asian population remain limited. This study was conducted to assess changes in left ventricular geometry, diastolic function, and CPO in heart failure patients following ARNI therapy compared to ACE inhibitors among Indonesian. This observational study employed a prospective cohort design involving 73 heart failure patients divided into two groups: the ARNI group and the ACE inhibitor group. Evaluations were conducted at first admission/recruitment and after three months period of therapy using echocardiography to assess parameters of left ventricular geometry (LVMI and RWT), diastolic function (E/e' ratio), and CPO. The use of ARNI or ACE inhibitors over three months showed a significant reduction in LVMI, accompanied by an improvement in diastolic function marked by a significant decrease in the E/e' ratio (p < 0.05). However, no significant differences were observed between the two groups. CPO values increased in both groups with a p-value < 0.05, where ARNI therapy showed a greater improvement compared to ACE inhibitors (p = 0.048). The use of ARNI and ACE inhibitors in heart failure patients can improve CPO, left ventricular geometry, and diastolic function, with ARNI therapy providing a better enhancement in CPO compared to ACE inhibitors.
Co-Authors Achdiat Agoes Adam, Erika Adi Purnawarman, Adi Aldri Frinaldi Amanda, Febrina Ambari, Ade Meidian Anwar Santoso Aria Kekalih Arifah, Medisa Roro Putri Nur Badai Bhatara Tiksnadi Bambang Budi Siswanto Bashori, Ahmad A. Basuni Radi Desandri, Dwita Rian Djanggan Sargowo Djeni, Chairatu Sadrina Dwiputra, Bambang Ekawati, Wahyu Elvira Sari Dewi Enitan, Seyi S. Erwinanto, Erwinanto Gusti, Naufal Hadi, Tjut F. Hamny Sofyan Harahap, Alida R. Harahap, Alida Rosita Herlina Dimiati, Herlina Indriyani, Damayanti Jannah, Riska Raudhatul Jasa, Zafrullah Kany Kamarlis, Reno K. Katsukawa, Hajime Kristianingrum, Niko Dima Kumboyono Kumboyono Kurniawan, Ferry D. Lestari, Nova D. Liza Salawati, Liza Machfud, Savinka Salsabiela Iriana Marfuah Marfuah Mudatsir Mudatsir Mudatsir Muhammad Ridwan Muhammad Riyan Munawarah, Iffah Munirwan, Haris Nina Widasari novia, rizki Novita Nurjani Nursuhaida, Haffa Syafana Pintaningrum, Yusra Putra, Magma Purnawan Putri, Cut JE. Renan Sukmawan Riswandha, Sofyan Saputra, Irwan Saputra, Jefri Dwi Sari, Indah P. Satuman Satuman Septi Nurhayati Sri Soenarti Subkhan, Muhammad Sunanto Ng Tambunan, Tresia Fransiska Ulianna Tambunan, Tresia FU. Taufiks, Nasyaruddin H. Taufiqurrahman Taufiqurrahman Taufiqurrahman Titin A Wihastuti, Titin A Triangto, Kevin Wicaksono, Sony Hilal Yanti, Budi Yuliezar Perwira Dara, Yuliezar Perwira Yuvhendmindo, Shahcoga L. ZAHRA, RITA Zulkarnain