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All Journal Al-Kimia Majalah Farmaseutik Pharmacology and Clinical Pharmacy Research Pharmaceutical Journal of Indonesia JURNAL FARMASIMED (JFM) BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian UNDIKMA Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Pengabdian Masyarakat Journal of Agropharmacy Dirya : Journal of Economic Management
Wardhani, Firdha Aprillia
Departement Of Clinical And Community Pharmacy, Faculty Of Pharmacy, University Of Jember
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Journal : Pharmacology and Clinical Pharmacy Research

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Correlation of Polypharmacy and Comorbidity with NIHSS Status in Ischemic Stroke Patient Wardhani, Firdha A.
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.38919

Abstract

Drug-related problems are a common problem among stroke patients due to comorbidities resulting from the complex management of stroke treatment leading to polypharmacy management. Studies show that 90% of stroke patients have drug-related problems (DRPs). However, there is limited information on the impact of comorbidities as risk factors for DRP prevalence and unfavorable prognosis in patients with ischemic stroke. This study aimed to determine the risk factors for DRP and clinical outcomes as modifiable comorbidities in ischemic stroke patients admitted to a tertiary hospital between January 2020 and October 2021 were indeed significant influences. The study was conducted retrospectively using a cross-sectional analysis of patient’s medical records. The study found no significant association between the presence of comorbidities and polypharmacy in patients with the incidence of DRP, although we found that the DRPs occurrence was found more in a patient with comorbidities and polypharmacy. Diabetes mellitus was found to have a significant association with no improvement in NIHSS scores in ischemic stroke patients. We found that diabetes mellitus patient had an increased risk of non-improvement NIHSS score 2,987 times compared to patients without diabetes mellitus. The second increased risk was the presence of comorbid hypertension (OR 1.352), the third was the occurrence of polypharmacy (OR 1,175), and the fourth was dyslipidemia (OR 1.138).
Co-Authors Adelia Firandi Amalia Wardatul Firdaus Amalia Wardatul Firdaus Aryani, Dhita Aryani, Dhita Evi Dian Agung Pangaribowo Didik Hasmono Dwi Koko Pratoko Dyan Wigati Ema Rachmawati Eryani, Mikhania Christiningtyas Fifteen Aprila Fajrin Firandi, Adelia Ika Norcahyanti Khrisna Agung Cendekiawan Kusumaningrum , Yunita Dyah Lina Winarti Nafisah Isnawati NANANG MUNIF YASIN Nia Kristiningrum Ramadhani, Nuril Izzati Farihatur RR. Ella Evrita Hestiandari Shinta Mayasari Shinta Mayasari Sinta Rachmawati Syafika, Devina Sarah Zulkarnain Permana ZULLIES IKAWATI