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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Nusantara Pengabdian Kampus: Jurnal Informasi Kegiatan Pengabdian Pada Masyarakat TRANSPUBLIKA INTERNATIONAL RESEARCH IN EXACT SCIENCES (TIRES) Media Kesehatan Politeknik Kesehatan Makassar Barigas: Jurnal Riset Mahasiswa
Angeline Novia Toemon, Angeline Novia
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Journal : Jurnal Ilmu Kefarmasian Indonesia

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Evaluation of the combination patch of betel leaf extract (Piper sp.) - ultrasonic assisted extraction as a transdermal delivery system on fibroblast cell formation and collagen density Valencia, Regina; Trinovita, Elsa; Shinta, Herlina Eka; Toemon, Angeline Novia; Ysrafil, Ysrafil
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1687

Abstract

The combination of red betel (Piper crocatum) and green betel (Piper betle L.) leaves is believed to act synergistically in enhancing wound healing. Transdermal patches offer advantages over conventional topical forms due to their sustained drug release, ease of application, and prolonged therapeutic effect. This study evaluated the histopathological effects of a combination patch containing betel leaf extracts for incision wound treatment in Wistar rats. The studies used an true experimental post-test-only control group design, five groups were tested: a blank patch (K−), a povidone-iodine patch (K+), and combination extract patches at concentrations of 7.5% (K1), 15% (K2), and 30% (K3), applied over 14 days with six animals per group. Patch characteristics were assessed through organoleptic tests, thickness, weight uniformity, folding endurance, and pH, while wound healing was evaluated through histological analysis of fibroblast cell counts and collagen density. Statistical analysis was conducted using the Kruskal-Wallis test followed by Mann-Whitney post-hoc tests. The 30% combination patch (K3) showed the most significant healing effect, with fibroblast counts exceeding 50 cells and dense collagen formation scoring +3. These results indicate that a transdermal patch combining Piper crocatum and Piper betle L. extracts effectively promotes wound healing by enhancing fibroblast proliferation and collagen synthesis.
Co-Authors Ahmad, Farah Fauziah Radhiyatulqalbi Arif Rahman Jabal Astoeti, Dileli Dharma Auliyah, Mayasin Tania Austin Bertilova Carmelita, Austin Bertilova Balyas , Abi Bakring Balyas, Abi Bakring Br Surbakti, Ranintha Dian Mutiasari, Dian Elsa Trinovita Hanasia, Hanasia Hasan, Muhamad Umar Muhtar Inarae, Gabriella Kesuma, I Putu Gede Candra Kurniawan, Mutiara Lestarisa, Trilianty Natalia Sri Martani Panueh, Jovanka Mangium Wijayanti Parhusip, Luther Putra S, Ravenalla Abdurrahman Al Hakim Sampurna Rian Ka Praja Salsabila, Ivah Salsabilah, Alfisa Fitri Sitompul, Sanggap Indra Steffany Angelina Monica Syamsul Arifin Teresa, Astrid Tjahjono, Herry Tori, Marthin Tri Widodo Turnip, Oktaviani Naulita Valencia, Regina Veronica, Anna Marthea Veronicha, Anna Marthea Widiarti, Astri Ysrafil, Ysrafil