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All Journal The Journal of Pure and Applied Chemistry Research JURNAL MUQODDIMAH : Jurnal Ilmu Sosial, Politik dan Hummaniora Walisongo Journal of Chemistry Indonesian Journal of Chemical Analysis (IJCA) Molekul: Jurnal Ilmiah Kimia Journal of Appropriate Technology for Community Services JURNAL BIOSHELL Jurnal Abdimas Kartika Wijayakusuma COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Jurnal Indonesia Sosial Teknologi Gunung Djati Conference Series Nanggroe: Journal Of Scholarly Service Nanggroe: Journal of Scholarly Service Bohr: Jurnal Cendekia Kimia
Sari, Meiyanti Ratna Kumala
Universitas Palangka Raya, Kalimantan Tengah, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Indonesian Journal of Chemical Analysis (IJCA)

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Advancements in NMR and IR Spectroscopy: Enhancing Metabolomics and Disease Diagnostics in the Health Sector: A Comprehensive Review Saputra, Rizki Rachmad; Ariefin, Mokhamat; Kumalasari, Meiyanti Ratna; Dongoran, Junita; Tampubolon, Mulani Jeni Lestari; Sulistiawati, Putri; Simangunsong, Sri Yulandari; Ariska, Risya; Paksi, Pandu Gizta Rapi; Siska, Amelia; Yanti, Jeddah; Maknun, Luluil
Indonesian Journal of Chemical Analysis (IJCA) Vol. 7 No. 2 (2024): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol7.iss2.art6

Abstract

Metabolomics has emerged as a critical field in understanding biological processes and disease mechanisms, necessitating advancements in analytical techniques to handle complex biological samples. This review explores the global landscape of metabolomics, with a focus on the use of spectroscopy and spectrometry. Techniques such as UV-Vis and Fourier Transform InfraRed (FTIR) spectroscopy offer fast and cost-effective metabolite tracing but are limited by their sensitivity, particularly for low-abundance metabolites. Nuclear Magnetic Resonance (NMR) spectroscopy, despite being less sensitive than mass spectrometry (MS), provides unparalleled structural information, distinguishing metabolites with similar mass-to-charge ratios. NMR's capability to detect metabolites in the 1-10 µM range highlights its effectiveness in metabolomics. This review categorizes advancements in these techniques, starting with global contributions to spectroscopy, followed by detailed discussions on FTIR strategies for metabolite tracing, and concluding with NMR's qualitative and quantitative applications in metabolomics and disease diagnostics. The review underscores the continuous development in sample preparation and data integration, enhancing the accuracy and applicability of these techniques, positioning NMR and FTIR as essential tools in modern metabolomic research.
Advances in Mesoporous Silica Nanoparticles: Synthesis, Characterization, and Biomedical Uses Saputra, Ozi Adi; Safitriono, Wahyu Nur; Istiqomah, Annisa; Kumalasari, Meiyanti Ratna; Irmawan, Muhammad; Wibowo, Fajar Rakhman
Indonesian Journal of Chemical Analysis (IJCA) Vol. 7 No. 2 (2024): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol7.iss2.art9

Abstract

Mesoporous silica nanoparticles (MSNs) have drawn significant attention due to their exceptional properties and diverse range of applications, particularly in nanomedicine. The distinctive properties of MSNs, such as their high surface area, tunable pore size, and versatile surface chemistry, make them ideal candidates for various biomedical applications. This review aims to present a detailed understanding of MSNs, from synthesis and characterization to their versatile applications in biomedicine, highlighting their significant potential in advancing healthcare technologies. The synthesis methods for MSNs were comprehensively discussed, emphasizing the influence of parameters like solvent, base, alkoxysilane concentrations, and template surfactants on the size and shape of the nanostructures. Different types of MSNs, including MCM-41, SBA-15, KIT-6, and hollow MSNs, are discussed, along with their synthesis protocols and unique characteristics. The review also covers various spectroscopic techniques, such as XRD, XPS, FTIR, NMR, and fluorescence spectroscopy, which are crucial for characterizing MSNs. Furthermore, the biomedical applications of MSNs are highlighted, demonstrating their potential in drug delivery systems, imaging, and diagnostics. The review concludes with a discussion of the future perspectives and challenges in the field, providing insights into potential developments and the prospects for clinical translation.
Co-Authors Adiwijaya, Saputra Anasthasya Isaura Silalahi Annisa Istiqomah, Annisa Ardi Sandriya Ariska, Risya Chuchita Chuchita, Chuchita Dongoran, Junita Elfrida Ratnawati Fajar Rakhman Wibowo Fariz Noorrahman, Nabil Gracia, Amanda Natania Hanna Esrani Togatorop Husna Syaima Imelya, Marsya Iqbal, Rendy Muhamad Irmawan, Muhammad Jeddah Yanti Jesika Nababan Jumiati Kalalinggi, Septaria Yolan Maknun, Luluil Mokhamat Ariefin Nababan, Jesika Nafisah, Zahrotun Ozi Adi Saputra, Ozi Adi Paksi, Pandu Gizta Rapi Pramudita, Dimas Pratika, Remi Ayu Purwanto, Ferry Qonita Awliya Hanif Rafsanjani, Muhamad Arief Rafsanjani, Muhammad Arief Rahman, Sudarman Riandy Putra Rizki Rachmad Saputra Safitriono, Wahyu Nur Simangunsong, Sri Yulandari Simanjuntak, Elfrida Roulina Simarmata, Sari Namarito Sipayung, Ronald Regen Siska, Amelia Siti Unvaresi Misonia Beladona Sugiyani, Tina Sulistiawati, Putri Tampubolon, Mulani Jeni Lestari Tesalonika, Lidya Venty Suryanti Wenika Simbolan Wulandari, Oktavia Rahmi Ysrafil, Ysrafil Yuni Damayanti Nainggolan Zahrotun Nafisah Zimon Pereiz