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All Journal Jurnal Ilmiah Farmasi Indonesian Journal of Pharmaceutical Science and Technology Pharmascience PARMACEUTICAL AND TRADITIONAL MEDICINE Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat MEDIA INFORMASI An-Nadaa: Jurnal Kesehatan Masyarakat Jurnal Riset Kefarmasian Indonesia BERNAS: Jurnal Pengabdian Kepada Masyarakat Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Pharmacy Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Farmasi Sains dan Praktis Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram GEMASSIKA: Jurnal Pengabdian kepada Masyarakat Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan Jurnal Farmasi Galenika Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Rahmayanti Fitriah
Universitas Borneo Lestrai
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Formulation and Optimization of Bisoprolol Fumarate Orally Fast Dissolving Film with Combination of HPMC E15 and Maltodextrin as Matrix Polymers Aristha Novyra Putri; Rahmayanti Fitriah
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.48 KB) | DOI: 10.24198/ijpst.v1i1.19150

Abstract

Bisoprolol fumarate is a drug belonging β blockers group, and specifically is selective β1 adrenergic receptor blocker, a class medicines used primarily in cardiovascular diseases. The drug has 9-12 hrs half life (t1/2) and shows bioavailability of more than 80%1. An orally fast dissolving film dosage form with drug in mouth are absorbed through buccal/oral mucosa in to systemic circulation avoiding first pass metabolism2. The study aimed to made of orally fast dissolving film bisoprolol fumarate by solvent casting method with combination of HPMC E15 and maltodextrin as matrix. Factorial design 23was applied to optimize the formula of orally fast dissolving film bisoprolol fumarate by varying level of polymer, it was HPMC E15 300 – 600 mg, maltodextrin 50 – 150 mg, and PEG400 50 – 90 mg. The optimum formula was determined by superimposed contour plot from various parameters: physical properties of orally fast dissolving film bisoprolol fumarate such as thickness, folding endurance, surface pH, in vitro disintegration, hidration study, and drug release for 300 second using Design Expert ® program. The study result showed that physical properties of 8 formulas such as organoleptic test were transparent, homogeny, and smooth in both of side; thickness 0.062 – 0.132 mm; weight variation 50.85 – 70.60 mg; folding endurance 987 – 2012; surface pH 6.69 – 6.99; disintegration (drop method) 18.33 – 20.76 sec; disintegration (petridish method) 27.63 – 30.41 sec; in vitro dissolution for 300 sec was 94.35 – 98.99%; and swelling index up to 30 second was 146.63 – 173.34%. Based on superimposed contour plot Design Expert® from factor response of folding endurance, surface pH, in vitro disintegration drop method, in vitro disintegration petridish method, swelling index, dan DE300with a statistically significant finding requires a P-value of 0.05 were obtained optimum formulas for the area in the range of HPMC E15 509.88 mg; Maltodextrin 108.63 mg; and PEG400 50 mg with the value of desirability 0.519.Key Words: bisoprolol fumarate, orally fast dissolving film, factorial design
Co-Authors Aesty Rahayu Akbar, Depy Oktapian Alfi, Muhammad Alya Sandrina Augesta Ariyanti Indryan Noor Azmi Yunarti Diena Raisa Nabyla Dinda Raflianti Dyera Forestryana Dyera Forestryana Eka Karlina Fitri Handayani Gracia Therecella Anabella Role Sinaga Hafiz Ramadhan Ika Maulida Nurrahma Islamiyah, Robiatul Liana Fitriani Hasymi M. Hadarani, M. Hadarani Mahriani Mahriani Maulana, Andika Jaya Muhammad Faisal Muhammad Fajrin Nor Muhammad Luthfi Aditya Muhammad Rus’an Hidayat Muhammad Zaini Murniati Murniati Nadia Wahyu Artati Noormalisa Noormalisa Nurul Mardiati Prihandini, Yustin Ari Radini, Muhammad Rahmatullah, Satrio Wibowo Ramadhan, Hafiz Ramadhani, Syahrizal Ratna Restapaty Reny Marliadi Ridho Sernawan Saputri, Revita Sihombing, Yuliana Syahrizal Ramadhani Wahyudi Wahyudi Wahyudi Wahyudi Wika Tiarawati Yanie, Akhmad