<![CDATA[Dyslipidemia is a lipid metabolism disorder characterized by an increase in total cholesterol, triglycerides, and Low-Density Lipoprotein (LDL), as well as a decrease in High-Density Lipoprotein (HDL). According to the 2018 Basic Health Research (Riset Kesehatan Dasar/RISKESDAS), 12.6% of the Indonesian population aged 55–64 years had high cholesterol levels along with very high LDL and triglyceride levels. The Mediterranean diet is a form of non-pharmacological therapy involving nutritional intervention for patients with dyslipidemia. This study aimed to examine the effect of adherence to the Mediterranean diet on lipid profiles and the Plasma Atherogenic Index (PAI) in dyslipidemic patients at a private clinic in Bandung. This research employed an observational analytic method with a prospective cohort design involving 30 patients with dyslipidemia. Subjects were selected using a systematic random sampling technique and categorized into three groups based on their adherence to the Mediterranean diet: low, medium, and high. At the end of the month, lipid profile parameters and PAI were measured. Data on total cholesterol, LDL, and HDL levels were analyzed using ANOVA and Tukey’s Post Hoc test, while triglycerides and PAI were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The results showed significant differences in total cholesterol (p = 0.007), LDL (p = 0.019), HDL (p = 0.006), triglycerides (p = 0.005), and PAI (p = 0.036) across the adherence groups. These findings suggest that higher adherence to the Mediterranean diet is associated with improvements in lipid profile and PAI. 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