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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian BIO-EDU: Jurnal Pendidikan Biologi Jurnal Alwatzikhoebillah : Kajian Islam, Pendidikan, Ekonomi, Humaniora Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Bangsa Journal of Nutraceuticals and Herbal Medicine
Eko Mugiyanto, Eko
Fakultas Farmasi, Universitas Pancasila
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Journal : Farmasains : Jurnal Farmasi dan Ilmu Kesehatan

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Nano antioxidant serum ethanol extract lime peel (Citrus aurantifolia S.) Fortuna, Putri Asabella; Mugiyanto, Eko; Waznah, Urmatul; Rahmasari, Khusna Santika
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 7 No. 2 (2022)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v7i2.35928

Abstract

Serum is a cosmetic that has received great attention from the industry, but the main challenges are appearance, transparency and public acceptance of herbal active ingredients. On the other hand, herbal cosmetics, such as those using lime peel, are also growing. This study aims to determine the antioxidant activity of lime peel made in a nano extract serum preparation. The method for making nano extracts uses ionic gelation with PSA (Particle Size Analyzer) and Zeta Potential characterization. The concentration of nano serum of lime peel ethanol extract used was 0.5%; 1%; and 3%. Meanwhile, the antioxidant activity testing method uses DPPH and data analysis applied one-way ANOVA then by Tukey test. The results of the nano extract serum formulation using organoleptic testing are transparent, thick and liquid, odorless, and feel moist on the skin. The results of nanoparticle characterization using PSA measurements with three replications were 295.1; 320.3; 385.4 nm and the results of testing the zeta potential of nanoparticles with three replications, namely 3.2; 3.4; 6.0mV. Furthermore, the results of the antioxidant activity test on the basis of the preparation formula are classified as weak (IC50 value of 156.22 μg/mL); Meanwhile, preparation formula with a concentration of 0.5%; 1%; 3% are considered very strong (IC50 value of 46.39 μg/mL; 41.06 μg/mL; 36.27 μg/mL). The results of data analysis consider significance of p value below 0.05. The conclusion is nano lime peel extract meets the requirements and the serum preparation meets the requirements and has antioxidant activity.
Comparison of activity test of ethanol extract and palm root infusion (Arenga pinnata) as an aphrodisiac Rochmat, M. Idhar Khoirul; Mugiyanto, Eko; Waznah, Urmatul; Nur, Achmad Vandian
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 8 No. 2 (2023)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v8i2.36346

Abstract

The palm tree (Arenga pinnata) contains secondary metabolites such as saponins, phenols, triterpenoids, alkaloids, and flavonoids that can be used as medicine, particularly as an aphrodisiac. Aphrodisiacs are natural substances, medications, or herbal supplements that have the potential to increase sexual arousal. The use of herbal aphrodisiac drugs has been increasing year by year in Indonesia. This study aims to determine the aphrodisiac activity of palm root water extract (Arenga pinnata) in test animals (Web Wiester mice). The preparation of the extract begins with the processing of palm roots, which are then made into an infusion of palm root water (Arenga pinnata). The method of making the palm extract uses infusion and maceration techniques. The aphrodisiac potential test was conducted in vivo using 32 Web Wiester mice, which were divided into 5 groups; the dosage was determined by dividing the mice into five groups (positive control, negative control, 0.5 ml infusion, 1 ml infusion, and extract). The characterization of aphrodisiac properties in the extract included testing the libido of mice (Mus musculus). The results showed that the extract test group with a dose of 250 Mg/KgBW had the highest mating retention among the other test groups.
Evaluation of the mucolytic activity of ethanol extract of Temu Ireng (Curcuma aeruginosa Roxb.) Waznah, Urmatul; Mufrodah, Nely; Wirasti, Wirasti; Mugiyanto, Eko
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 9 No. 2 (2024)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v9i2.34760

Abstract

Curcuma aeruginosa Roxb., known as Temu Ireng, is a species within the Zingiberaceae family that has been empirically noted for its potential as a cough remedy. Temu Ireng contains alkaloids, flavonoids, and saponins, which play crucial roles in mucus liquefaction. This study aims to investigate the mucolytic activity of the ethanol extract of Curcuma aeruginosa Roxb. In this study, we used an experimental method. The extract was obtained via maceration and analyzed in vitro for its ability to reduce the viscosity of bovine intestinal mucus using a digital viscometer. Bovine intestinal mucus was utilized due to its compositional similarity to human mucus. Test sample concentrations of the Temu Ireng extract were 1.0%, 1.5%, and 2.0%, with acetylcysteine serving as the positive control. Mucolytic activity was indicated by a decrease in mucus solution viscosity. The data were analyzed using one-way ANOVA. The results demonstrated a decrease in mucus viscosity for the Temu Ireng extract test solutions, with statistical analysis indicating a significant difference between the negative control and both the positive control and the Temu Ireng extract samples at concentrations of 1.5% and 2.0%, with p-values of 0.032 and 0.030 respectively (p<0.05). The study concludes that the ethanol extract of Curcuma aeruginosa Roxb. exhibits mucolytic activity at concentrations of 1.0%, 1.5%, and 2.0%.
Co-Authors Achmad Vandian Nur, Achmad Vandian Ainin, Shabrina Antonius Padua Ratu Fadhilah, Isna Fatmala, Rizki Fortuna, Putri Asabella Fuad, Asfal Khafid, M. Iskandar Khusna Santika Rahmasari Mufrodah, Nely Najihah, Veni Haqiqotun Ningrum, Wulan Agustin Nisa, Husna Idza Auziadzatun Nuniek Nizmah Fajriyah Nurul Aktifah, Nurul Nurul Janah, Fatimah Oktaviani, Riska Kurnia Oktaviani, Riska Kurnia Oktaviani Pambudi, Dwi Bagus Permadi, Yulian Wahyu Qulub, Muhammad Syifaul Raharjo, Setyo Tri Rochmat, M. Idhar Khoirul S Slamet, S Slamet . Syarifah, Dewi Ulhaq, M Daffa’ Dhiya’ Urmatul Waznah Vandian, Achmad Waznah , Urmatul Waznah, Urmatul Wirasti, W Wirasti, Wirasti Yulian Wahyu Permadi