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All Journal Universa Medicina Jurnal Biomedika dan Kesehatan Jurnal Pengabdian Masyarakat Trimedika
Rully Ayu Nirmalasari, Rully Ayu
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Jurnal Biomedika dan Kesehatan

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Dilema Managemen Tatalaksana Persalinan pada Anencephali sebagai Janin Letal Yunitra, Imelda; Wiranti, Hervi; Nirmalasari, Rully Ayu; Mayasari, Atut Cicih; Dhanardono, RM Denny; Maharani, Laksmi
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Anencephaly is a congenital anomaly of the central nervous system, caused by a disruption in brain and skull development of a fetus, which includes the disruption of the cerebral hemispheres, cerebellum, spinal cord, and pyramidal tract. This is a lethal condition that most fetuses born with this condition cannot survive after being delivered. The prevalence of this condition is 1 in 1000 deliveries. Early detection through prenatal ultrasound testing is essential to make a correct and precise plan for managing the pregnancy and delivery process, thus avoiding potential maternal complications. We reported a 33-year-old pregnant woman who was diagnosed with having anencephalic fetus at 24 weeks of pregnancy. The patient has been informed about this condition and offered a termination, but she refused to do so and is willing to continue the pregnancy. Induction of labor was planned at 40 weeks of pregnancy, but the process was impaired, so a cesarean section was performed to save the mother. The baby was delivered with anencephaly, as shown by the ultrasound result, and died 2 days after being delivered. The mother recovered well and was given education about the importance of folic acid intake for the next pregnancy. Conclusion of this case was labor management of anencephalic fetus was planned according to medical indication, with a special individual approach due to the obstetric condition. Yet, the delivery method should be based more on the mother's condition rather than the baby's, including the maternal emotional factor.
Hubungan Parameter Laboratorium dengan Derajat Klinis COVID-19 pada Kehamilan Nirmalasari, Rully Ayu; Surjadi, Lily Marliany; Maharani, Laksmi; Lisnawati, Yuyun; Mangun, Dhea
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.291-299

Abstract

Background Pregnant women were one of the most susceptible groups because they are vulnerable to respiratory infection. They may get more severe symptoms due to their physiological changes during pregnancy including the immunological response. This study was performed to find whether there is an association between laboratory parameters (Hb, leukocytes, platelet, neutrophils, lymphocyte, monocyte, NLR, PLR and CRP) and the severity of Covid-19 infection in pregnant women. Methods This study is a retrospective cohort study using secondary data from patient’s medical records at Persahabatan General Hospital, Jakarta from March to June 2021. Results Pregnancy cases with COVID-19 in this study were in the mean of 29 year age. Most of them are in the third trimester of pregnancy. 80.5% from 67 patients have no- mild symptom while 19.5% have moderate to severe symptom. There are no difference in vital sign nor oxygen saturation at first admission. Lower level was found in the parameter of leukocyte, lymphocyte and monocyte.  Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein increase as the degree of severity increase.  The mean neutrophil in pregnant women with moderate to severe COVID-19 symptom was 80.49±7.47 while median NLR value was of 6.76 (2.73-18.71) . Conclusions Neutrophil, neutrophil-to-lymphocyte ratio and C-reactive Protein has associate significantly to severity symtomps of COVID-19 in pregnancy.
Co-Authors Atut Cicih Mayasari Dhanardono, RM Denny Laksmi Maharani Lisnawati, Yuyun Mangun, Dhea Mario Mario Rachmiyani, Irmiya Surjadi, Lily Marliany Wiranti, Hervi Yudhisman Imran, Yudhisman Yunitra, Imelda