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All Journal PHARMACON Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Jurnal Pengabdian Al-Ikhlas BERNAS: Jurnal Pengabdian Kepada Masyarakat Health Media JUKESHUM: Jurnal Pengabdian Masyarakat Jurnal EduHealth Journal Prima Health Science Jurnal Kesehatan dr. Soebandi Medical Sains : Jurnal Ilmiah Kefarmasian J-CEKI
Shinta Mayasari
Fakultas Ilmu Kesehatan Universitas Dr Soebandi, Jember, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Pharmaciana: Jurnal Kefarmasian

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In vitro antidiabetic activity of Peperomia pellucida extract and fraction by alpha-amylase inhibition pathway Sholihatil Hidayati; Shinta Shinta Mayasari; Lindawati Setyaningrum; Ayu Dwi Wardani; Qurrotul Aini
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.547 KB) | DOI: 10.12928/pharmaciana.v12i2.21874

Abstract

The development of type 2 diabetes is influenced by the important role of post-prandial blood glucose management. One strategy in controlling post-prandial hyperglycemia can be done by inhibiting the digestion of dietary carbohydrates through inhibition of alpha amylase enzyme. Natural alpha amylase enzyme inhibition strategy that utilizes natural ingredients is an important alternative in the development of antidiabetic drugs. One of the plants that has the potential to be developed as an antidiabetic is Peperomia pellucida. This study aims to examine the effects of antidiabetic extracts and fractions of Peperomia pellucida in inhibiting alpha amylase enzyme. The research was conducted by determining the total flavonoid using quercetin standard. Antidiabetic studies were carried out by looking at the activity of extracts and fractions of Peperomia pellucida in inhibiting alpha amylase enzyme using visible spectrophotometry method. Data analysis was performed by entering the absorbance value into the standard quercetin curve, while the IC50 value of in vitro antidiabetic activity was determined by entering the value 50 on the curve between the sample concentration and % inhibition of the alpha amylase enzyme. The results showed that the total flavonoid values of the ethanol extract and the ethyl acetate fraction of the herb were 88.24 mg QE/g extract and 80.45 mg QE/g fraction, respectively. Based on the results, the inhibition of alpha amylase enzyme showed that the ethanol extract and the ethyl acetate fraction of the herbs had inhibitory activity with the IC50 value of the ethanol extract 1065.54 g/mL and the ethyl acetate fraction 906.53 g/mL. While the control of acarbose showed an IC50 value of 379.45 g/mL. The ethanol extract and the ethyl acetate fraction of Peperomia pellucida herbs have the potential to be developed as antidiabetic agents with the mechanism of action of inhibiting the activity of the alpha amylase enzyme.
In vitro antidiabetic activity of Peperomia pellucida extract and fraction by alpha-amylase inhibition pathway Sholihatil Hidayati; Shinta Shinta Mayasari; Lindawati Setyaningrum; Ayu Dwi Wardani; Qurrotul Aini
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.547 KB) | DOI: 10.12928/pharmaciana.v12i2.21874

Abstract

The development of type 2 diabetes is influenced by the important role of post-prandial blood glucose management. One strategy in controlling post-prandial hyperglycemia can be done by inhibiting the digestion of dietary carbohydrates through inhibition of alpha amylase enzyme. Natural alpha amylase enzyme inhibition strategy that utilizes natural ingredients is an important alternative in the development of antidiabetic drugs. One of the plants that has the potential to be developed as an antidiabetic is Peperomia pellucida. This study aims to examine the effects of antidiabetic extracts and fractions of Peperomia pellucida in inhibiting alpha amylase enzyme. The research was conducted by determining the total flavonoid using quercetin standard. Antidiabetic studies were carried out by looking at the activity of extracts and fractions of Peperomia pellucida in inhibiting alpha amylase enzyme using visible spectrophotometry method. Data analysis was performed by entering the absorbance value into the standard quercetin curve, while the IC50 value of in vitro antidiabetic activity was determined by entering the value 50 on the curve between the sample concentration and % inhibition of the alpha amylase enzyme. The results showed that the total flavonoid values of the ethanol extract and the ethyl acetate fraction of the herb were 88.24 mg QE/g extract and 80.45 mg QE/g fraction, respectively. Based on the results, the inhibition of alpha amylase enzyme showed that the ethanol extract and the ethyl acetate fraction of the herbs had inhibitory activity with the IC50 value of the ethanol extract 1065.54 g/mL and the ethyl acetate fraction 906.53 g/mL. While the control of acarbose showed an IC50 value of 379.45 g/mL. The ethanol extract and the ethyl acetate fraction of Peperomia pellucida herbs have the potential to be developed as antidiabetic agents with the mechanism of action of inhibiting the activity of the alpha amylase enzyme.
Co-Authors Afnan Septi Mulyani Afnan Septy Mulyani Afrizal Maulidan Rachmawan Agustin, Ayu Tri Alfarisi, Hilmi Pratama Alfi Nur Ramadhani Alvia Putri Priyono, Rosyidatul Amalia Wardatul Firdaus Ambari, Yani Anas, Mohammad Nizar Anggitasari, Wima Anggraeni, Linda Suci Anggraeni, Lutvi Arista Wahyu Ningsih Atmanegara, Stivani Yanti Aulia, Andira Aura Denaneer Mulya Aura Denaneer Mulya Ayu Angger Putri M. Soleh Ayu Dwi Wardani Bekti Kusuma Primadani Damayanti, Mita Eka Damayanti, Selvi Danny Dwi F Danny Dwi Firmansyah Darrojah, Urfi Narva’u DEWI RAHMAWATI Dewi, Novi Rosita Dina Trianggaluh Fauziah Dinayah, Syafinatud Dinda Febri Puspitasari Dinda Febri Puspitasari Dwi Koko Pratoko Dyan Wigati Fadli Muhammad F Fadli Muhammad Fathoni Fadli Muhammad Fathony Fahrur Rozi Shodiqi Fendy Prasetyawan Fitria, Ayu Florentinus Dika Octa Riswanto Hasanah, Adinda Shofiatul Hasiseh Hasiseh Heri Setyo Budi Hidayati, Sholihatil Indah Suciati Iski Weni Pebriarti Ismanti, Septie Putri Kanaya Dewayanti Khrisna Agung C Khrisna Agung Cendekiawan lindawati setyaningrum Maheswari, Anindya Dinarya Martina, Ina Muhammad Alvin Yovansya Mu’affan, Achmad Adha Nabila, Talitha Vanian nafisah isnawati Nanda Pradwitha Fariansiska Novyananda Salmasfattah Pangesti, Yuli Pebriarti, Iski Weni Permatasari, Shafira Restu Pramesti, Lita Aulia Putra, Zulkarnain Permana Putri Ramadani Putri Ramadhani Putri, Masitah Nurwidiya Qurrotul Aini Rahmadania Affelia Dianto Ramadhan Bagus Cahyono Ramadhan, Muhammad Ridho Ratna Amelia Ratna Amelia Ressi, Monica Risqi Wahyudi rofiqoh rofiqoh savitri, Lisa Siti Aisyah Siti Hotima Siti Hotimah Siti Nur Maulita Soleh, Ayu angger Putri M. Stevi R izky Anandha Susanti, Dhina Ayu Swastika, Melur Tri Taniya Tri Oktavia Ningrum Tuhfatul Hilmits T Tuhfatul Hilmits Tsania Ulum, Miftahol Wanda Tri Agustin Wardani, Ali Ridho Wardhani, Firdha Aprillia Wima Anggitasari Yola Kristina Cendani Yuneka Saristiana Zulkarnain Permana