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All Journal As-syifaa Jurnal Farmasi GANEC SWARA INTEK: Jurnal Penelitian Jurnal Gema Ngabdi Elastisitas Jurnal Ekonomi Pembangunan Jurnal Abdimas Sangkabira Agrimansion: Agribusiness Management & Extension KNOWLEDGE: Jurnal Inovasi Hasil Penelitian dan Pengembangan Seminar Nasional Pengabdian Kepada Masyarakat Pharmaceutical Reports Business Management Jurnal Konstanta : Ekonomi Pembangunan Journal Microbiology Science West Science Business and Management West Science Journal Economic and Entrepreneurship West Science Interdisciplinary Studies Jurnal Oportunitas : Ekonomi Pembangunan West Science Interdisciplinary Studies MPSJ Cognitive
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Journal : As-syifaa Jurnal Farmasi

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STUDI IN SILICO SENYAWA AKTIF DARI JAHE (Zingiber officinale) DAN KERSEN (Muntingia calabura L.) SEBAGAI INHIBITOR MAIN PROTEASE (Mpro) DARI SARS-CoV-2 Tahir, Masdiana; Maryam, St.
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1070

Abstract

Coronavirus disease is an infectious disease caused by the SARS-CoV-2 coronavirus, which is an RNA virus consisting of four structural proteins and sixteen non-structural proteins responsible for viral multiplication. One of the proteins is the main protease (Mpro). Inhibition of Mpro is potentially effective as a COVID-19 drug because it will cause the loss of the virus's replication and transcription abilities, so that the virus is unable to survive. The purpose of this study is to determine what chemical compounds in ginger (Zingiber officinale) and kersen (Muntigia calabura) plants have the potential as COVID-19 drugs with the Mpro inhibition mechanism. This research method is in silico using molecular docking method with PyRX software. The results showed that of the 70 chemical compounds from ginger (Zingiber officinale), there are 3 compounds that have potential because they have better activity than the N3 inhibitor comparison ΔG -8.0 kcal/mol, namely Zingiberoside B (-8.6 kcal/mol), Zingiberoside C (-8.5 kcal/mol) and Shogasulfonic acid D (-8.2 kcal/mol). Meanwhile, of the 10 chemical compounds from Jamaica cherry (Muntigia calabura), there are 4 chemical compounds that have potential as Mpro SARS-CoV-2 inhibitors, namely Kempferol 7-(6''-p-coumarylglucoside) or Biondnoid A (-9. 1 kcal/mol), Hiravanone (-8.4 kcal/mol), 5,7,3',4' - Tetrahydroxy - 6, 8 - di - C -prenylflavanone (-8.4 kcal/mol), and Myrtillin (-8.3 kcal/mol).
ANALISIS BAHAN KIMIA OBAT NATRIUM DIKLOFENAK DALAM SEDIAAN JAMU ASAM URAT YANG BEREDAR DI KOTA TIMIKA Maryam, St.; Suhaenah, Asriani; Rusniyanti, Rusniyanti
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1031

Abstract

Uric acid herbs are an alternative that is still widely used by the community as an anti-inflammatory and pain reliever. The increasing public interest in returning to traditional medicine has prompted several manufacturers to add medicinal chemicals to their preparations to produce a faster and maximum therapeutic effect, one of which is diclofenac sodium. The study aimed to analyze the chemical ingredients of the uric acid herbs circulating in Timika City and to find out the level of diclofenac sodium contained therein. The method used is High Performance Liquid Chromatography (HPLC) with reverse phase, where the mobile phase is methanol: aquabidestilata (80:20) and the stationary phase is column C-18. Based on the test results, nine uric acid herbs showed positive results with retention times at the same value as diclofenac sodium. The content of diclofenac sodium obtained were code A herb of 4.135 mg/L, B herb : 36.300 mg/L, C herb : 18.530 mg/L, herb D : 473.219 mg/L, herb E : 40.991 mg/L, herb F : 77.165 mg/L L, herb G : 93.109 mg/L, herb H : 52.700 mg/L, and herb I : 297.123 mg/L. All herb samples tested were unfit for public use because they contained the chemical drug sodium diclofenac
Co-Authors A. Muflihunna, A. Agustiani, Eka Agustin, Verren Regina Akung Daeng Alodya, Baiq Putri amelia yolanda, amelia Aminah Aminah Annisa, Nurfiqah arifin, nurrizky afiah Arini, Gusti Ayu Asri, Fitriani Asriani Suhaenah Azzahra, Resqinah B, Moh Baktiar Desi, Nilma Sri EMI SALMAH Fajar, Suwandy Fitriana Fitriana Fuady, Helmi Hidayanti, Nurul Hidayat, M. Ali Akbar Indriyani , Maulida Irwan Irwan Irwan, M Irwan Iwan Harsono Khoirul Umam Lambang Basri Said M. Firmansyah M. Irwan M. Irwan, M. Irwan Masdiana Tahir, Masdiana Mayanah, Dewi Muhammad Awaludin Muhammad Firmansyah, Muhammad Mustika, Nurfadila Muzakkir Baits, Muzakkir Nur Awwalunnisa, Nur Ohorela, Indah Kartika p, irmawan jamal Parobi, Rizki Prima Astuti Handayani Putra, Iwan RAHMAN, ANDI AMALIA RAMADHANI Rahmawati, Rahmawati Rais Razak, Rais Ramdani, Ridho Rekhan. T, Muh Rafli Rusniyanti, Rusniyanti Rustam, Julis Tina Sahri Sahri Salahuddin, Muthia Amaliah Salim, Medina Sasliani, Sasliani Satarudin Siti Helmyati Syam, Nurizzah Aulia Sya’baniyah Herman, Nur Fajriah Wahidin Wahidin Wahyudi, M. Ilham Wiwik Handayani