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All Journal Media Kesehatan Politeknik Kesehatan Makassar JOURNAL OF INFORMATION SYSTEM RESEARCH (JOSH) Journal Islamic Economics Ad Diwan Media Kesehatan Politeknik Kesehatan Makassar Media Implementasi Riset Kesehatan
Andini, Mira
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Religion Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Media Kesehatan Politeknik Kesehatan Makassar

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Faktor Predisposisi, Klasifikasi Subgrup, Biomarker dan Mekanisme Pencegahan Obesitas : Tinjauan Pustaka Andini, Mira; Budirman, Budirman; Hasanah, Besse Uswatun
Media Kesehatan Politeknik Kesehatan Makassar Vol 20 No 1 (2025): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v20i1.1414

Abstract

Obesity has emerged as a critical global public health challenge, driven by multifactorial predisposing elements such as sociodemographics, behavior, genetics, and obesogenic environmental factors. This systematic literature review synthesizes evidence on obesity subgroups (e.g., metabolically healthy obesity [MHO], metabolically unhealthy obesity [MUO]), biomarkers (microRNA, adipokines, oxidative stress markers, gut microbiota, and lipid accumulation product index), and prevention strategies. A systematic search of the PubMed, Scopus, and Web of Science databases (2010–2023) identified peer-reviewed studies addressing the etiology, classification, and interventions for obesity. Key findings highlight the interaction between early-life nutritional deficiencies and subsequent metabolic dysregulation, the role of visceral adipose tissue (VAT) in refining the obesity phenotype, and the diagnostic potential of biomarkers such as miR-222 and leptin. Prevention strategies, including school-based nutrition education, taxes on ultra-processed foods, and bariatric surgery for severe cases, demonstrate varying efficacy across populations. This review emphasizes the need for a multidimensional approach tailored to regional contexts, particularly in low- and middle-income countries where the dual burden of malnutrition persists. By integrating evidence of genetic-environmental interactions and new biomarkers, this research provides actionable insights for policymakers and health practitioners to reduce the growing burden of obesity. Keywords: predisposing factors, subgroup classification, biomarkers, prevention mechanisms, obesity
Efektivitas Suplementasi Zink Dan Sinbiotik Dalam Mendukung Kesehatan Lansia: Tinjauan Sistematis Hartono, Rudy; Rusli, Rusli; Amir, Aswita; Ipa, Agustian; Andini, Mira; Mas’ud, Hikmawati
Media Kesehatan Politeknik Kesehatan Makassar Vol 20 No 1 (2025): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v20i1.1459

Abstract

As the elderly population grows, life expectancy increases. This poses significant challenges to their health, particularly in maintaining immune and digestive function. Zinc and synbiotics (a combination of probiotics and prebiotics) are two promising nutritional interventions for supporting the health of the elderly. This article reviews the effects of zinc and synbiotics, as well as their combination, on elderly health, with a primary focus on immune response, sarcopenia, and fatigue. Based on a systematic review of literature from PubMed, Scopus, and Google Scholar, 600 articles were narrowed down to 10 selected articles (2017–2024) specifically involving randomized controlled trials, using the Cochrane Risk of Bias Tool and the PRISMA algorithm. The findings indicate that zinc supplementation has the potential to enhance the immune system and reduce inflammation, contributing to improved quality of life for the elderly. Meanwhile, synbiotics have been proven effective in improving gut health, addressing microbiota dysbiosis commonly found in the elderly, and enhancing gut microbiota balance that supports immune function. Zinc helps improve immune function and brain function, while synbiotics improve digestive health and reduce inflammation. When combined, both provide stronger and complementary effects in maintaining overall health in the elderly. Further research with stronger designs is needed to validate the benefits of both, and clinical recommendations for nutritional interventions in the elderly can be expanded based on these findings. Keywords: zinc, synbiotics, elderly, immune response
Co-Authors Abizar Agustian Ipa Aswita Amir Budirman, Budirman Haerani Haerani Hartono, Rudy Hasanah, Besse Hasanah, Besse Uswatun Khaer, Ain Lala, Manji Mas’ud, Hikmawati Mawardi R. Rusli Simarmata, Linda Puspa Ayu Sirait, Barthy Ladi C. Sitanggang, Intan Syarif, Haerani Ulil Albab Yaumil Fachni Tandjungbulu