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DIMAS ANDRIANTO
Departemen Biokimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Bogor 16680
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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Penambatan Molekuler Senyawa Bioaktif Daun Wungu (Graptophyllum Pictum (L) Griff) sebagai Inhibitor Tirosinase Abdul Aziz; Dimas Andrianto; Mega Safithri
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36219

Abstract

Melasma is a skin disorder characterized by hyperpigmentation of the skin in areas exposed to sunlight and is included in the dominant skin disorder category in several countries. Meanwhile, data from the Food and Drug Administration shows that cosmetic products have progressed from 0.01% to 57.4% in terms of registered products over the last six years. Currently, melasma treatment and cosmetic applications as a whitening agent were carried out by regulating tyrosinase activity through the use of compounds such as kojic acid which poses a health risk. Therefore, it was necessary to have other alternatives that can regulate tyrosinase activity without harming health. This study aimed to determine inhibitory effects of wungu leaf (Graptophyllum pictum (L) Griff) bioactive component as an agent to inhibit tyrosinase activity through a molecular docking approach. A total of 28 wungu leaves bioactive components as a result of the analysis of Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography-Flame Ionization Detector (GC-FID) were tested for their inhibitory effects on tyrosinase activity. Linolenic acid and phytol were ligands that have the best inhibition on tyrosinase enzyme activity with affinity energies of -5.8 kcal/mol and -5.4 kcal/mol, respectively, and inhibition constants of 55.718 M and 109.489 M.
Co-Authors Abdjad Asih Nawangsih Abdul Aziz Abdurrahman Zaky Achyar, Catellia Auliany Agus Setiyono Ahmad Faqih Aisyah Sahara Akbar Rafiqi Akhmad Endang Zainal Hasan Alivianisa Nabilatusyifa Amrista Fanzani Kananga Antonius Padua Ratu Apipah Aprianti Arya Arendra Assa’addah, Habibah Aulya, Silvy Ayu Tri Nursyarah Bella Fatima Dora Zaelani Dadan Rohdiana Daeli, Gavriel Allenfar Danty Oktiana Prastiwi Dara Anggun Vachyra Dea Khalissa Anidya Destiandani, Khansa Dewi Eriyanti Dewi Kurniasih Dewi Purnamasari Dimas Andrianto Djarot Sasongko Hami Seno Dwicesaria, Maheswari Alfira Eka Wahyu Purnama Elgiani Yassifa Yulia Nur Insari Emidar Khusnu Eny Ida Riyanti Eriyanti, Dewi Etik Mardliyati, Etik Eva Harlina Fahmi Hafid Faisal Rahman Falah, Samsul Febrina, Adella Fina Febrianti Firdaus, Dzikri Anfasa Firdaus, Muhamad Fajar Firmansyah, Muhammad Ade Fitrilia, Tiana Galuh Adhiyaksa Ashari Gholam, Gusnia Meilin Gina Oktaviani Sabrina Hardinsyah Hasim - HASIM DANURI Hasim Hasim Heddy Julistiono Heddy Julistiono Hudayanti, Martini Husnawati, . I MADE ARTIKA Ike Agustiani Ikromatul Hasanah Ilham Gilang Cahya Ahmada Imelia Dewi Inawati Inawati Irfan Abdul Aziz Irsal, Riyan Alifbi Putera Istikorini, Yunik Jaka Aryantara Kuntala LAKSMI AMBARSARI Latifah Kosim Darusman Latifah, Aminahtun Lestari, Ella Deffi Madyastuti, Rini Maria Bintang Mega Safithri Muhamad Alvin Adriyan Muhammad Farhan Muhammad Irfansyah Pradika Muhammad Zulkifli Mutholaah Mutmainnah Agustiawan Umar Nabilla, Rahmah Najmah, Najmah Nayanda, Najwa Putri Nina Tri Kusumawati Noor Farikhah Haneda Noviyan Darmawan Nurliani Bermawie Nusyarah, Ayu Tri Olive Wisepti Pratama Oyi Candra Santoso Putri Prasetyo, Dwiandra Hadi Purwanto, Ukhradiya Magharaniq Safira Putri, Salsabila Yasmin Budi Qolbiyah, Syifa Ainul Qomariah Hasanah Qurrotu Ayni R. Haryo Bimo Setiarto Raden Roro Fine Ayu Putri Raisyadikara, Fadila Rara Annisaur Rosyidah Rara Annisaur Rosyidah Rara Annisaur Rosyidah Rimbawan Rimbawan Rini Kurniasih, Rini Riska Susila Putri Rosyidah, Rara Annisaur Sabrina Firdayani Rahmah Sanro Tachibana Sari, Sintia Permata Sigiro, Ria Heni Silvy Aulya Siti Maesunah Gilang Maya Slamet Hamzah Sri Anna Marliyati Sri Mariati Sri Wahyuni Suci Hermita Sulistiyani Sulistiyani , SULISTIYANI SULISTIYANI Sulistiyani Sulistiyani Syaefudin Syaefudin Syamsul Falah Syarthibi, Ahmad Syifa Khaerani Tukan, Maria Magdalena Nona Motu Ukhradiya Magharaniq Safira Purwanto Ulfah Juniarti Siregar Vina Oktovianti Waras Nurcholis Wilujeng, Retno Winata, Grace Marlina Yupi Yulianita Arifin Yusriya, Rifqi Zaelani, Bella Fatima Dora Zulfikar Muchammad