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All Journal Medical Journal of Indonesia Jurnal Plastik Rekonstruksi
Sudjatmiko, Gentur
Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Civil Engineering, Building, Construction & Architecture Medicine & Pharmacology Other

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Journal : Medical Journal of Indonesia

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Chlorhexidine-alcohol versus povidone-iodine as preoperative skin preparation to prevent surgical site infection: a meta-analysis Anggrahita, Tasya; Wardhana, Aditya; Sudjatmiko, Gentur
Medical Journal of Indonesia Vol 26, No 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (451.733 KB) | DOI: 10.13181/mji.v26i1.1388

Abstract

Background: Surgical site infection remains substantial problems to surgeons and patients as it increases the morbidity, mortality, length of stay, hospital cost, rate of re-admission, and rate of re-surgery. This study aims to compare the use of chlorhexidine-alcohol versus povidone-iodine for preoperative skin preparation to prevent surgical site infection.Methods: The literature search was conducted through the PubMed database on November 2015. Included studies were RCTs with the year of publication up to 2015 which compared the use of chlorhexidine-alcohol versus povidone-iodine in its effectiveness reducing surgical site infection in adult patients. The quality of the study was assessed using Jadad Score. A meta-analysis was conducted in the included study to obtain a pooled estimate of the effect size. The evidence of heterogeneity and publication bias was also assessed.Results: Six RCTs with a total of 2,080 patients were included in the meta-analysis. It showed that the use of chlorhexidine-alcohol was associated significantly with fewer SSIs (pooled risk ratio=0.60 (95% CI=0.45-0.79)) and fewer positive skin culture results (pooled risk ratio, RR=0.38 (95% CI=0.28-0.51)) compared with povidone iodine.Conclusion: Preoperative skin antisepsis with chlorhexidine is more effective than povidone-iodine in preventing surgical site infection.
Co-Authors A., Nur A., Teuku Anggrahita, Tasya Anindhawati, Nur Atmadja, Tessa Miranda Bangun, Kristaninta Buchari, Frank D., Ishandono Djaprie, Shelly M Djoenaedi, Intania eko heryadi, eko Hakim, Intan Frischilla Hakim, Intan Friscilla Harsono, Anastasia Dessy Ibadurahman, Ibadurahman Irwansyah, Denny K. P., Ayu Diah K., Nadia Kreshanti, Prasetyanugraheni Kusumastuti, Nadia Laureen Supit Lestari, Puri Ambar Mahandaru, Danu Marita, Adinda Mukarramah, Dewi A. Mukarramah, Dewi Aisyah P., Nandita Melati Pribadi, Sweety Rani Septrina Raymond, Benni Raymond, Benny S., Asrofi Sandhi, Afriyanti Sari, Tessa Puspita Simamora, Huntal Sundoro, Ali Tania, Vika Tedjo, A. Tiza, Melina Utama, Defry Yundari, Yundari