Article Per Year (5 Year)
p-Index From 2020 - 2025
2.144
P-Index
This Author published in this journals
All Journal BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Jurnal Biologi Tropis Jurnal Gizi Kerja dan Produktivitas Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat Ilmu Kesehatan Media Penelitian dan Pengembangan Kesehatan
Muhammad Andry
Program Studi Farmasi, Institut Kesehatan Helvetia Medan, Sumatera Utara, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
AKTIVITAS ANTINEFROLITIASIS EKSTRAK ETANOL DAUN SAMBUNG NYAWA [Gynura procumbens (LOUR.) MERR.] PADA TIKUS PUTIH JANTAN (Rattus norvegicus) Evalina Tarigan, Rida; Mayanti, Tri; Andry, Muhammad; Surbakti, Chemayanti
Media Penelitian dan Pengembangan Kesehatan Vol. 33 No. 1 (2023): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v33i1.1908

Abstract

Gynura procumbens is a diuretic plant that has been used traditionally to cure kidney stones. In order to determine the calcium levels in the rats' kidneys, the anti-nephrolithiasis activity of male white rats was tested in this study.This research method was carried out experimentally in a laboratory which included sampling, plant identification, making simplicia, making ethanol extract of sambung nyawa leaves, characteristics of simplicia, phytochemical screening, administering animal test preparations, then the data was analyzed using the Anova test. Oral administration of succulent leaf extract is done at three different doses: 50, 100, and 200 mg/kg bw. A positive control is provided with Batugin elixir, which is 0.54 mL/125 g BW and induced at a volume of 7.5 mL/125 g BW/day using ethylene glycol 0.75% and ammonium chloride 2%. The study's findings demonstrated that, with a kidney stone inhibitor percentage of 31.71%, the ethanol extract of Sambung Nyawa leaves at a dose of 200 mg/kg BW was more successful in preventing the formation of kidney stones than doses of 50 mg/kg BW and 100 mg/kg BW. This proves that the ethanol extract from Sambung Nyawa leaves can be an alternative way to prevent kidney stones. The conclusion is that the ethanol extract of Gynura procumbens L. leaves has antinephrolithiasis activity in male white rats, especially at a dose of 200 mg/kg BW. It also reduced calcium oxalate levels in mice induced by ethylene glycol and ammonium chloride.
Studi Bioteknologi Komputasi (Bioinformatika) Senyawa Vitexin Pada Kombucha Bunga Telang Vitexin Sebagai Antioksidan dan Antikanker M. Fariz Fadillah; Firman Rezaldi; Raisa Fadila; Muhammad Andry; Barolym Tri Pamungkas; Syariful Mubarok; Susiyanti Susiyanti; Vevi Maritha
Jurnal Gizi Kerja dan Produktivitas Vol 5, No 1 (2024): May
Publisher : Fakultas Kedokteran Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/jgkp.v5i1.24993

Abstract

Manfaat minuman probiotik kombucha bunga telang sebagai produk hasil dari proses fermentasi menggunakan teknologi bioteknologi mengandung berbagai senyawa bioaktif atau metabolit sekunder yang berperan penting dalam menjalankan berbagai aktivitas farmakologinya sehingga memiliki potensi sebagai bahan aktif obat maupun kosmetik. Salah satu senyawa yang berperan penting dan diuji pada penelitian ini adalah vitexin yang berasal dari golongan flavonoid dan memiliki aktivitas sebagai antioksidan maupun antikanker. Tujuan dari penelitian ini adalah untuk membuktikan bahwa senyawa vitexin memiliki aktivitas dalam menangkal radikal bebas dan kanker secara in silico sebagai gambaran awal untuk pengembangan kandidat bahan aktif obat baru. Metode penelitian yang digunakan berbasis laboratorium kering menggunakan software bioinformatika. Adapaun software yang digunakan pada penelitian ini ialah Discovery Studio 2021, ChemDraw Ultra 8.0, ChemDraw Ultra 8.0 dan MGL Tools 1.5.7.   Langkah pertama yang dilakukan ialah mengunduh struktur protein (3ZBF) dari Protein Data Bank (PDB) dan membuat struktur ligan (vitexin). Selanjutnya dilakukan preparasi protein untuk mencegah kemungkinan gangguan dalam proses ikatan antara ligan dan reseptor serta preparasi ligan untuk mencapai bentuk optimal dari ligan yang memiliki konformasi terbaik. Langkah berikutnya adalah validasi docking dengan cara melakukan docking ligan bawaan terhadap protein untuk membandingkan ligan hasil proses docking (ligan validasi) dengan ligan bawaan dan melihat nilai Root Mean Square Deviation (RMSD). Hasil penelitian yang diperoleh yakni senyawa vitexin memiliki nilai energi bebas -6.97 kkal/mol, nilai konstanta inhibisi 7800 nM dan dapat berinteraksi pada asam amino protein ROS, antara lain GLU2027, MET 2029, LEU2086, ASP2033 dan GLY2032 dengan nilai RMSD 1.383 Å. Kesimpulan dari penelitian ini adalah penambatan senyawa vitexin yang terkandung pada kombucha bunga telang terhadap inhibitor ROS memiliki nilai RMSD < 2 Å, mampu berinteraksi dengan asam amino GLY2032 yang merupakan penyebab terjadinya resistensi terhadap inhibitor ROS (Crizotinib)serta dapat memberikan gambaran awal sebagai kandidat obat baru yang diregulasi untuk memiliki aktivitas farmakologi sebagai antioksidan maupun antikanker.
Pengaruh Perbedaan Metode Ekstraksi Maceration dan Microwave Assisted Extraction (MAE) Terhadap Penetapan Kadar Flavonoid Total Buah Ara (Ficus racemosa L.) Andry, Muhammad; Ligo, Azzura; Anggi, Reza Destri; Pradita, Diding; Luthvia, Luthvia; Nasution, Muhammad Amin; Pertiwi, Nia Novranda; Arifin, Arfiani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.859

Abstract

Figs (Ficus racemosa L.) are an essential source of bioactive components such as phenols, terpenoids, flavonoids, and alkaloids with antioxidant properties. Two extraction methods are used to extract flavonoids from figs: conventional and non-conventional. This study aimed to determine the effect of different extraction methods—maceration and Microwave Assisted Extraction (MAE)—on the total flavonoid content in figs (Ficus racemosa L.). The research was conducted using a laboratory experimental method. The procedures included collecting and preparing plant materials, producing simplicia, evaluating simplicia characteristics, conducting phytochemical screening, preparing extracts, and determining total flavonoid content. The results showed that the maximum wavelength of quercetin was 438 nm, with a regression equation of Y = 0.0669x + 0.0084. The average absorbance values of fig extract using the maceration method were 0.216 with methanol, while the MAE method was 0.280 with methanol. The average percentage of flavonoid content using the maceration method was 0.1245% with methanol, while with the MAE method, it was 0.1623% with methanol. The total flavonoid content of fig extract using the maceration method was 1.2451 mgQE/g extract with methanol, while with the MAE method, it was 1.6238 mgQE/g extract with methanol. The study concluded that the highest total flavonoid content was found in the methanol extract obtained through MAE. This extract had a value of 1.6238 mgQE/g extract.
Difference in Effectiveness Gel Dosage form Green Papaya (Carica papaya L.) Skin Ethanol Extract and Gel Dosage form Green Papaya Seed Against Cutibacterium acnes Bacteria Diana, Vivi Eulis; Abadi, Hafizhatul; Rumanti, Ruth Mayana; Andry, Muhammad
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.9330

Abstract

Many things can cause acne, including stress, fatty foods, inappropriate or unsuitable makeup, and pollution. Cosmetics made from plants are safer to use. Papaya skin and seeds (Carica papaya L.) have antibacterial properties in the form of alkaloids, tannins, steroids, saponins, and flavonoids. This study aims to determine the comparison of the antibacterial power of young papaya skin ethanol extract gel and young papaya seed ethanol extract gel against Cutibacterium acnes bacteria. The research method is experimental with various formulas consisting of F0 (0%), F1 (11%), F2 (12%), and F3 (13%). The results of the study obtained antibacterial gel preparations from the three concentrations showed that the organoleptic test of the young papaya fruit skin ethanol extract gel preparation was light brown, blackish brown, dark blackish brown. The homogeneity test was homogeneous. The pH test was 5.9, 6.5, 7.0, and the seed ethanol extract gel preparation was light brown, dark brown, thick dark brown. The homogeneity test was homogeneous. Test pH 5.0, 5.6, 5.5, 5.1. The conclusion of this study is that the antibacterial effectiveness of young papaya fruit skin ethanol extract gel is greater than young papaya fruit seed ethanol extract gel at a concentration of 13% against Cutibacterium acnes bacteria.
ANTIFUNGAL Trycophyton rubrum AND Trycophyton mentagrophytes IN LIQUID BATH SOAP FERMENTED PROBIOTIC KOMBUCHA FLOWER TELANG (Clitoria ternatea L) AS A PHARMACEUTICAL BIOTECHNOLOGY PRODUCT Pamungkas, Barolym Tri; Safitri, Ayu; Rezaldi, Firman; Andry, Muhammad; Agustiansyah, Lucky Dita; Fadillah, M. Fariz; Hidayanto, Fajar; Hariadi, Hari
Biotik Vol 10 No 2 (2022): JURNAL BIOTIK
Publisher : Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/biotik.v10i2.15160

Abstract

Telang flower kombucha (Clitoria ternatea L) is a functional probiotic drink that has antifungal properties. This study aimed to examine the antifungal activity of the probiotic bath soap formulation fermented kombucha telang flower against Trycophyton rubrum and Trycophyton mentagrophytes. This research method was carried out experimentally in an in vitro laboratory. The formulation of the fermented kombucha bath soap for the flower of telang was made with varying concentrations of 20%, 30%, and 40%. The preparation of probiotic bath soap for kombucha telang flower was tested for its antifungal activity against the bacteria T. rubrum and T. megantrophytes using the disc diffusion method. The working procedure includes the manufacture of bath soap preparations, and antifungal activity tests on the probiotic kombucha bath soap preparations of telang flower. The results of the study were positively correlated based on the one-way ANOVA test with f count greater than f table and showed that telang flower kombucha in the form of probiotic bath soap had antifungal activity against T. rubrum and T. mentagrophytes as a whole. The concentration of 40% was the highest concentration in the probiotic soap preparations fermented kombucha telang flower with an average inhibition zone diameter of 17.70 mm in T. rubrum species and 17.30 mm in T. mentagrophytes species. The average value of the diameter of the inhibition zone is included in the strong category.
Peningkatan Pengetahuan Masyarakat Mengenai Swamedikasi Demam Flu dan Batuk Melalui Pendidikan Kesehatan Andry, Muhammad; Shufyani, Fahma; Naldi, Jefri
Jurnal Pengabdian Masyarakat Ilmu Kesehatan Vol 3, No 2 (2022): Edisi Juli
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/.v3i2.5591

Abstract

Kesehatan adalah keadaan sejahtera dari badan, jiwa dan sosial yang memungkinkan setiap orang hidup produktif secara sosial dan ekonomi. Pembangunan kesehatan sebagai salah satu upaya pembangunan nasional diarahkan guna tercapainya kesadaran, kemauan dan kemampuan untuk hidup sehat bagi setiap penduduk agar terwujud derajat kesehatan masyarakat yang optimal. Untuk mewujudkan derajat kesehatan yang optimal tersebut maka diselenggarakan upaya kesehatan dengan pemeliharaan, peningkatan kesehatan (promotif), pencegahan penyakit (preventif), penyembuhan penyakit (kuratif) dan pemulihan kesehatan (rehabilitatif) yang dilaksanakan secara menyeluruh, terpadu dan berkesinambungan serta diselenggarakan bersama antara pemerintah dan masyarakat. Upaya masyarakat untuk mengobati dirinya sendiri dikenal dengan istilah swamedikasi. Swamedikasi biasanya dilakukan untuk mengatasi keluhan-keluhan dan penyakit ringan yang banyak dialami masyarakat, seperti demam, flu dan batuk. Swamedikasi menjadi alternatif yang diambil masyarakat untuk meningkatkan keterjangkauan pengobatan. Pada pelaksanaannya swamedikasi dapat menjadi sumber terjadinya kesalahan pengobatan (medication error) karena keterbatasan pengetahuan masyarakat akan obat dan penggunaannya. Tujuan dari kegiatan pengabdian masyarakat ini yaitu untuk meningkatkan pengetahuan masyarakat Dusun II Randu Alas, Desa Ara Condong, Kec. Stabat mengenai swamedikasi demam, flu dan batuk dan untuk memberikan informasi informasi yang tepat agar  dapat terhindar dari penyalahgunaan obat (drug abuse) dan penggunasalahan obat (drug misuse). Metode yang digunakan yaitu penyuluhan atau pemberian pendidikan kesehatan berupa ceramah dan tanya jawab. Hasil penyuluhan yang telah dilakukan kepada masyarakat menunjukkan bahwa kegiatan penyuluhan yang diberikan dapat dinilai bermanfaat dikarenakan peserta kegiatan mendapatkan ilmu dan wawasan yang bersifat baru tentang swamedikasi.
Article Review: Potential use of Andaliman Fruit as an Antibacterial Karo-Karo, Sry Ulina; Nabila, Nabila; Hartini, Putri Tri; Andry, Muhammad; Ligo, Azzura; Rezaldi, Firman
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7423

Abstract

This research examines the potential of andaliman fruit (Zanthoxylum acanthopodium) as an antibacterial agent. Andaliman fruit is known to contain bioactive compounds such as alkaloids, flavonoids and saponins which have the potential to inhibit the growth of pathogenic bacteria. The antibacterial activity test was carried out using the agar diffusion method against several test bacteria, including Escherichia coli and Staphylococcus aureus. The results showed that andaliman fruit extract had significant antibacterial activity, indicated by the inhibition zone formed around the extract impregnation disc. The highest activity was noted against Staphylococcus aureus, which is a gram-positive bacterium. These findings indicate that andaliman fruit has the potential to be developed as an effective natural antibacterial agent. Further research is needed to identify the specific active compound and its antibacterial mechanism of action.
Antibacterial Activity and Thin-Layer Chromatography (KLT) Ethanol Extract of Dragon Scale Leaves (Drymoglossum piloselloides (L.) C. Presl) Against Bacteria Staphylococcus epidermidis Syahputri, Hindri; Pertiwi, Nia Novranda; Sari, Syilvi Rinda; Simanjuntak, Monica Nelly; Sari, Melia; Andry, Muhammad; Nasution, Muhammad Amin; Rezaldi, Firman
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7442

Abstract

The dragon scale plant is a plant containing flavonoid compounds, tannins, alkaloids, saponins. Flavanoid compounds, alkaloids, and tannins are found in dragon scales that are thought to provide antibacterial effects. Thin Layer Chromatography Test (KLT). On quarstin there is a stain distance spot of 1 cm and an 8 cm motion phase with an Rf value of 0.129 and in the extract there is a stain spot of 7.3 cm with an 8 cm motion phase with an Rf value of 0.9. In Staphylococcus epidermidis bacteria from the average of the largest inhibitory zones are applied to the extract with a concentration of 20%. The diameter of the average inhibitory zone formed around the disc paper at each concentration is: 5% 10.5 mm ± 0.20 at a concentration of 10% 11.26 mm ± 0.20 and a concentration of 20% 12.2 mm ± 0.30 each concentration has a strongly categorized response. Ethanol extract of dragon scale leaves (Drymoglossum piloselloides (L.) C. Presl) has antibacterial activity against Staphylococcus epidermidis. The diameter of the inhibitory zone that is best formed in the treatment of dragon scale leaf ethanol extract against Staphylococcus epidermidis bacteria with a concentration of 20%12.2 mm±0.30 is 12.2 mm with a strong category.
Test The Activity of Microgel Preparations from Skin Extract Jengkol (Pithecellobium lobatum Benth) on The Healing of Cut Wounds in White Rats (Rattus novergicus) Utama, Rezza Fikrih; Situmorang, Renni Paska; Husaini, Fahri; Andry, Muhammad; Wijayanti, Fitria Eka Resti
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7609

Abstract

The skin is the largest and heaviest organ in the body, covering its outer surface. Wounds are often experienced by everyone due to the loss of epithelial integrity of the skin. Jengkol fruit skin is useful as a burn medicine and antiseptic to test the activity of microgel preparations from jengkol skin extract (Pithecellobium lobatum Benth) on healing cuts in white rats (Rattus novergicus). This study was a true experimental, post test control only design using the Completely Randomized Design (CRD) statistical method. The data were analyzed statistically using SPSS and continued with ANOVA test to see significant differences between the 5 treatment groups. The results of the study obtained microgel preparations that had activity for healing cuts on the backs of white rats, namely the F3 preparation with a concentration of 15% jengkol skin extract with wound observation for 12 days. In conclusion, cuts on the backs of white rats can be healed with jengkol skin extract.
Formulation of Natural Food Coloring Granules from Dragon Fruit Peel Extract (Hylocereus polyrhizus) and Effectiveness Test in Reducing Blood Glucose Levels Rudang, Singgar Ni; Ginting, Indra; Andry, Muhammad
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7635

Abstract

Anthocyanin is one of the many compounds in dragon fruit skin that can be used as an antioxidant. Dragon fruit skin can also lower blood glucose levels. The fact that cases of diabetes mellitus are increasing every year shows that this disease needs serious treatment. This study aims to make dragon fruit skin extract formulated in the form of granules and make dragon fruit skin extract granules that meet the requirements as natural food coloring and to determine the content and effectiveness of dragon fruit skin extract (Hylocereus polyrhizus) which can lower blood glucose levels. This research method is experimental. The One Way Anova test and the Tukey HSD post-hoc test were used to analyze the data. The outcomes showed that there were 9 granule recipes that met the assessment test necessities. After being induced by 20% fructose solution, the glucose level study revealed that the treatment of dragon fruit skin extract at 100, 200, and 400 mg / kgBW was able to lower blood glucose levels in test animals. Winged serpent natural product skin concentrate can be formed as granules. Equations 2 and 3 produce the best tone. The consequences of the review reasoned that winged serpent natural product skin remove (Hylocereus polyrhizus) at dosages of 100, 200 and 400 mg/kgBW was viable in decreasing blood glucose levels in guinea pigs prompted by 20% fructose arrangement and a portion of 200 mg/kgBW gave an impact of lessening blood glucose levels that was practically equivalent to the positive control.
Co-Authors Abadi, Hafizhatul Abas, Mohd Ihsanuddin Bin Agustiansyah, Lucky Dita Aji, Andrey Anggi, Reza Destri Arfiani Arifin Ayu Safitri Diana, Vivi Eulis Fajar Hidayanto, Fajar Firman Rezaldi Fitri, Khairani Ginting, Indra Hari Hariadi, Hari Hartini, Putri Tri Hindri Syahputri Husaini, Fahri Karo-Karo, Sry Ulina Khairani, Tetty Noverita Ligo, Azzura Luthvia, Luthvia M. Fariz Fadillah M. Fariz Fadillah Mardianto Melia Sari, Melia Muhammad Amin Nasution Mukhali, Hassan Basri bin Nabila, Nabila Naldi, Jefri Nia Novranda Pertiwi Ningtias, Anggitha Pamungkas, Barolym Tri Pradita, Diding Puteri, Cut Intan Annisa Rachelli, Rachelli Raisa Fadila Rezaldi, Firman Rida Evalina Tarigan Rudang, Singgar Ni Rumanti, Ruth Mayana Sari, Syilvi Rinda Sarumaha, Paska Eli Shufyani, Fahma Sibero, Jitasari Tarigan Simahate, Sadjnah Simanjuntak, Monica Nelly Situmorang, Renni Paska Surbakti, Chemayanti Susiyanti Susiyanti Syariful Mubarok Tri Mayanti Utama, Rezza Fikrih Vevi Maritha Wijayanti, Fitria Eka Resti Ziza Putri Aisyia Fauzi