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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Aisyah : Jurnal Ilmu Kesehatan Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Kepada Masyarakat Ungu ( Abdi Ke Ungu) Jurnal Pustaka Mitra : Pusat Akses Kajian Mengabdi Terhadap Masyarakat PharmaCine : Journal of Pharmacy, Medical and Health Science Jurnal Dharma Pendidikan dan Keolahragaan
Damayanti Abdul Karim, Dewi
Institut Teknologi Sumatera
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Aisyah : Jurnal Ilmu Kesehatan

 1 
Pre-Dominance Herbs Medicine against Alzheimer’s Disease, In Vivo Studies: A Literature Review Vicko Suswidiantoro; Fikriya Ridlawati; Dewi Damayanti Abdul Karim; Mida Pratiwi; Riza Dwiningrum; Wina Safutri; Diah Kartika Putri; Iga Mayola Pisacha; Kaka Widi Rahayu
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No S1: Supplement
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (699.011 KB) | DOI: 10.30604/jika.v8iS1.1728

Abstract

Objective: Alzheimer's disease is a progressive, unremitting, neurodegenerative disorder that affects wide areas of the cerebral cortex and hippocampus. Abnormalities are usually first detected in the brain tissue involving the frontal and temporal lobes, then slowly progressing to other areas of the neocortex. The study aimed: to summarise pre-dominance herbs medicine with neuroprotective effects for Alzheimer’s disease. Method: Searching at PubMed (during 2001-2021), the last research was performed in December 2001; relevant websites; and scanning of reference list of relevant articles. There were no language or publication restrictions. Search for keywords in MeSH (medical subject heading) with the words ‘Alzheimer’s disease, dementia, cognitive impairment, in vivo. Results: six plants medicine In vivo preclinical studies founds the medicinal plants have promising potential to prevent Alzheimer's disease. Abstrak: Objektif: Alzheimer yaitu penyakit degeneratif yang berhubungan dengan kerusakan saraf pada area cerebral cortex dan hippocampus. Gangguan ini dapat diketahui atau terdeteksi dari adanya perubahan pada lobus frontal dan temporal serta berkembang menuju neocortex. Tujuan: merangkum keunggulan tanaman obat herbal yang memiliki aktivitas neuroprotektif pada Alzheimer. Metode: pencarian data melalui PubMed (pada rentang tahun 2001-2021), pencarian dilakukan juga terkait penelitian yang relevan. Tidak ada batasan dalam pemilihan Bahasa. Pencarian dilakukan dengan memasukkan kata kunci pada MeSH (medical subject heading) berupa Alzheimer, dementia, gangguan kognitif, in vivo. Hasil: terdapat 6 tanaman herbal yang sudah dilakukan uji prekilins in vivo yang memiliki potensi menjanjika dalam pencegahan terjadinya Alzheimer
Ethanol Extract Burn Gel Formulation of Bay Leaves (Syzygium polyanthum (Wight.) Walp.) Dwi Ayu Andini, Annisa; Simanullang, Gayatri; Damayanti Abdul Karim, Dewi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 1 (2024): March 2024
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i1.2754

Abstract

Burns are skin tissue damage caused by hot objects or hot liquids. One of the potentially healing plants for burns is the bay leaves (Syzygium polyanthum (Wight.) Walp.). Bay leaves ethanol extract contains flavonoids known for their anti-inflammatory properties, which can aid in wound healing. This study aimed to determine the formulation and effectiveness of a gel made from ethanol bay leaves extract. Bay leaves were extracted using the maceration method with a 70% ethanol solvent; then, its extract was formulated into gel preparations. Following the formulation,the researchers conducted physicochemical evaluations and burn effectiveness trials using New Zealand albino rabbits. The research results indicated that the burn gel formulations with 3% and 6% concentration variations exhibited favourable physical properties, including organoleptic, homogeneity, and pH from 5.33 to 5.8, spreadability from 4.77 to 5.55 cm, adhesion strength from 5.47 to 11.6 seconds, and viscosity ranged from 12.507 to 16.080 cPs. The 15-day burn effectiveness test revealed no significant differences, indicating that the reduction in wound diameter was relatively consistent across all test groups. The percentages of wound healing in the negative control, bioplacentone, F1, and F2 were 42.48%, 54.73%, 43.84%, and 65.89%, respectively. Therefore, F2 demonstrated the best wound-healing performance.
In Silico Testing of Cocoa Pod Husk (Theobroma cacao L.) and Kersen Leaves (Muntingia calabura L.) Extracts as Candidate Drugs for Type 2 Diabetes Damayanti Abdul Karim, Dewi; Mayola Pisacha, Iga; Safutri, Wina
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 2 (2024): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i2.2952

Abstract

Diabetes mellitus is a metabolic disorder caused by elevated blood glucose levels. The incidence of diabetes mellituscontinues to rise globally, including in Indonesia. Type 2 diabetes mellitus is the most common type due to the inabilityof pancreatic beta cells to produce sufficient insulin. Kersen leaves (Muntingia calabura L.) and cocoa pod husk(Theobroma cacao L.) are natural ingredients rich in quercetin and are widely found in Indonesia. A higher quercetincontent correlates with its potential as an antidiabetic candidate. The aim of this research is to develop a standardizedcomprehensive herbal medicine from a combination of cocoa pod husk extract and kersen leaves extract, which isexpected to produce more potent antidiabetic activity with a clearly understood mechanism. This research employs anexperimental laboratory method, including in silico testing, to determine the target proteins of bioactive compounds andanalyze their interactions with alpha-glucosidase and GLUT4, as well as to obtain preliminary toxicity data. The in silicoresults show that quercetin has the best binding affinity compared to natural AGI ligands and GLUT4 targetmacromolecules. There is no amino acid residue similarity interaction was found between quercetin and the targetmacromolecules of AGIs and GLUT4, suggesting that quercetin may potentially bind to eNOS and HIF-1? receptors. Thepharmacokinetic predictions indicate that quercetin has a good pharmacokinetic profile, as it meets several of Lipinski'sRule of Five criteria, making it suitable for oral use.
LITERATURE REVIEW: PHARMACOLOGICAL AND TOXICOLOGICAL EFFECTS OF PLANTS FROM THE SOLANACEAE FAMILY Damayanti Abdul Karim, Dewi; Safutri, Wina; Hammami, Akmal; Ayu Chandra, Ananda
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.2417

Abstract

Solanaceae is a family of flowering plants with 83 genera and 2,925 species spread throughout the world. People reuse natural medicines that have been passed down from generation to generation because medical medicines have a big tendency to cause many side effects. This research aims to examine the pharmacological effects and toxicity of plants in the Solanaceae family. This research used 10 plant species, including potatoes (Solanum tuberosum L.), golden berries (Physalis angulata L.), tomatoes (Solanum lycopersicum L.), red chilies (Capsicum annuum L.), cayenne peppers (Capsicum frutescens L.), tobacco (Nicotiana tabacum L.), paprika (Capsicum annuum var. grossum), amethyst (Datura stramonium L.), Turkey berry (Solanum torvum Sw.), and black nightshades (Solanum nigrum L.). The journal search method used in this research is the Boolean System method (AND and OR) using the Google Scholar and Sinta databases. The results obtained from this research were that among the 10 plant species of the Solanaceae family studied, there were 3 pharmacological effects with the most data modes, including antimicrobial, anti-inflammatory, and anti-oxidant effects.
Formulation and Antioxidant Activity Test of Phycocyanin Phytosomal Gel from Green Algae Extract (Spirulina platensis) Adela, Nita; Kartika Sari, Untia; Damayanti Abdul Karim, Dewi; Ratnasari, Devi
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 1 (2024): March 2024
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i1.2766

Abstract

Green algae (Spirulina platensis) contains phycocyanins are useful as natural antioxidants. Spirulina platensis extract in phytosome gel preparation intended to increase sorption efficiency, physical stability and antioxidant activity. The purpose of this study was to examine the effect of variations ratio of extract to soy lecithin on phytosome characteristics, addition of phytosomes to gel characteristics, and efficiency of sorption on the IC50 of the gel. Extraction of Spirulina platensis using maceration. Optimization of the phytosome formula was carried out with ratio of extract to lecithin, 1:1, 1:2, 1:3. Evaluation of phytosomes showed spherical vesicles, particle size 627.9 nm, polydispersity index 0.382, absorption efficiency of 94%, 95%, 96%. Physical evaluation of the gel showed good results in organoleptic, homogeneous, pH in range 6.3-6.4, viscosity in range 3896-3992 cPs, spreadability in range 6-6.5 cm, stickiness in range 5-6 seconds. Based on results of the irritation test, there was no irritation in each formula. The results of the physical stability test for 6 cycles at 4°C and 40°C showed all formulas had stable in all evaluation results except a decreasing pH. The IC50 results of Spirulina platensis extract and phytosome gel 6.53 µg/mL and 21.59 µg/mL are classified as super strength antioxidant category.
Co-Authors Adela, Nita Ahmad Sutomo Akhmad, Atika Dalili Atika Nabila, Novrillia Ayu Chandra, Ananda Azry Ayu Nabillah Bayu Satriawan, Ahmad Boy Sembaba Tarigan Daskar, Annajim Diah Kartika Putri Dirga Dirga Dwi Ayu Andini, Annisa Dwi Oktarosada Erny Amalia Lestari Evanggeulista, Arnanda Fadia Zahra, Alya Faizal, Doni Fikriya Ridlawati Hammami, Akmal Hidayaturahmah, Rizky Iga Mayola Pisacha Jannah, Aryn Fatkhul Kaka Widi Rahayu Kartika Sari, Untia Katika Putri, Diah Lestari, Fina Aulika Mayefis, Delladari Mayola Pisacha, Iga Mendrofa, Alexander Yoel Harazachi Mida Pratiwi Mida Pratiwi Nabilla, Novrilia Atika Nisa Yulianti Suprahman Nur Aminudin Oktariza, Yasinda Oktriyanto, Aldila Fajar Pisacha, Iga Mayola Purwanti, Etik Putri, Diah Kartika Ramadhani, Untia Kartika Sari Ratnasari, Devi Rismawan, Iqfan Adi Riza Dwiningrum Rooswita, Putri Amelia Safei, Imam Simanullang, Gayatri Suswidiantoro, Vicko Syaifurrahman, Amir Syaikhul Aziz Wina Safutri Wina Safutri Winni Nur Auli