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Journal : BALI MEDICAL JOURNAL (BMJ)

DIFFERENCES OF TUMOR MASSES AND HEMOGLOBIN LEVELS IN CERVICAL CANCER SQUAMOUS CELL TYPE PATIENTS TREATED WITH COMBINATION OF PACLITAXEL AND CARBOPLATIN CHEMOTHERAPY Noviyani, R.; Suwiyoga, K.; Lesmana, I.; Niruri, R.; Tunas, K.; Budiana, and I N. K.
BALI MEDICAL JOURNAL Vol 3 No 1 (2014)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Paclitaxel and carboplatin are standard operating procedure for chemotherapy treatment of cervical cancer squamous cell carcinoma at Sanglah General Hospital, Bali-Indonesia. Chemotherapy improves outcome of cancer treatment. However, chemotherapy brings also a variety of adverse effects and complications. This study aims to evaluate the therapeutic and adverse effects of chemotherapy in patients with squamous cell cervical cancer. Methods: This is a case study of six patients with cervical cancer underwent chemotherapy paclitaxel and carboplatin 3-series at Sanglah General Hospital, Bali-Indonesia during January to November 2013. The therapeutic effect of chemotherapy was assessed from cervical cancer tumor mass measured before and after chemotherapy 3-series. The adverse effect of chemotherapy was determined from hemoglobin levels measured before and after chemotherapy. Data were analyzed using a paired t-test with a level of confidence of 95% using the SPSS to find out the differences. Results: In this study we found that there is a difference between tumor mass pre and post 3 series chemotherapy within p < 0.05. In term of toxic effect, we also obtained that there were difference of hemoglobin between pre and post of treatment within p < 0.05. Conclusion: Paclitaxel carboplatin as a chemotherapy drug in patients with cervical cancer is highly recomended when seen from the effects of reduced tumor size, and has a low side effect of anemia (anemia grade 1).
Co-Authors ., Ni Putu Ayu Laksmini Anak A. A. W. P. Dewi Ayu Laksmini, Putu Budiana, Nyoman Damayanti, Cokorda Istri Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Dewi Puspita Apsari Dewi, Anak A. A. W. P. Dewi, Ni Ketut Cintya Farmani, Putu Ika Karma Gayatri, Ni Kadek Weni Diah I Gusti Kamasan Arijana I Gusti NAWW Putra I Kadek Swastika I Ketut Suwiyoga I Made Sudarmaja I Made Sudarmaja I Nyoman Gede Budiana I Nyoman Mahayasa Adiputra I Nyoman Mangku Karmaya I Putu Darma Wijaya I Putu Prisa Jaya . I Putu Riska Ardinata I. Lesmana Ida Ayu Dewi Wiryantini Intan Puspa Kurniastuti, A.A. Ayu Komang Indah Laksmini , Putu Ayu Luh Nela Andriani Luh Putu Ratna Sundari Made Ary Pradnyawati Made Karma Maha Wirajaya Manuaba, I.A. Ratih Wulansari Mulana, Victorinus Alfred Saptiono Mulana, Viktorinus Alfred Saptiono Ni Luh Ariwati Ni Luh Gde Ari Natalia Yudha Ni Luh Putu Eka Diarthini Ni Luh Rustini Ni Luh Rustini Ni Made Linawati Ni Made Sudiari Ni Putu Aryati Suryaningsih Ni Putu Widya Astuti Ni Wayan Mita Arisia Nurwiyanti, . Nyoman Titin Brimantari Nyoman Trisna Aryanata Oktayanti, Leny Prapti Wujani, Ni Luh Gede Puspa, Intan Putri, Dhiancinantyan Windydaca Brata Putu Ayu Asri Damayanti Putu Ayu Asri Damayanti Putu Ayu Indrayathi Putu Ika Farmani Putu Indah Budi Apsari R. Niruri Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rini Noviyani Sagun Chandra Yowani Sanjaya, I Putu Maheswara Dharma Septiari, I Gusti Ayu Agung Sri Laksemi, Dewa Ayu Agus Suadnyana, Ida Ayu Astiti Teri, Komang Triastawan, I Komang Agus Viktorinus Alfred Saptiono Mulana Vitalia Fina Carla Rettobjaan Widowati, I Gusti Ayu Rai - Widyani, Ni Made Wimpie I Pangkahila Wintariani, Ni Putu Wirajaya, Karma Maha Yudha, A.A. Ngurah Bagus Arista Yuniantari, Ni Wayan