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Maigoda, Tonny Cortis
Poltekkes Kemenkes Bengkulu
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Journal : Jurnal Ilmu Kefarmasian Indonesia

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Penyembuhan Luka Diabetes dan Aktivitas Antimikroba dari Gel Ekstrak Melastoma malabathricum L. dan Psidium guajava L. pada Tikus Sprague Dawley Refdanita Refdanita; Tonny Cortis Maigoda; Firdaus Firdaus; Barakatun Nisak; Teodhora Teodhora
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1390

Abstract

Diabetes mellitus (DM) is a degenerative disease characterized by abnormalities in carbohydrate, lipid, and protein metabolisms. This research was aimed at the gel’s pharmacological activity, the extract’s potential in treating diabetic wounds in male rats of Melastoma malabathricum L leaves (ML) and Psidium guajava L leaves (PL), as well as microbiological activity. Viscous extracts of ML and PL were prepared in gel dosage form with concentrations of 4% and 6%. Clindamycin was used as a positive control. This study was conducted using an experimental laboratory method, and the study population included white male rats. The pharmacological activity was tested in the form of a gel dosage formula, and the rats were made diabetic using alloxan. The potential of the extract was observed in healing diabetic wounds in male rats. ML and PL leaf extract gels affect wound healing in diabetic patients. This can be seen from the change in diameter. Wound swab examination revealed the presence of bacteria Klebsiella pneumoniae and Staphylococcus aureus. Secondary metabolites of flavonoids, tannins, steroids, and saponins help stimulate the regeneration of epithelial cells and tissues. The results for wound healing of 4% and 6% gel formulations were derived from maturation data on day 10.
Co-Authors Agus Triyono Ahmad Dahlan ahmad rizal Ahmad Rizal Ahmad Sulaeman Ainun Nadhifah, Ainun Aliyah Rosalina Anang Wahyudi Anggela, Mesi Apriani, Zoli Ayu Pravita Ayu Pravita Sari Barakatun Nisak Budi Setiawan Darwis Demsa Simbolon Desri Suryani Dewi Lusiani Dicki Bakhtiar Purkon Dwi Preci Anugrah Efrida, Solha Eliana Eliana Emy Yuliantini Ester Angelina Winanti Ritonga Faizah Min Fadhlillah Firdaus Firdaus Firdaus Firdaus Hari Hariadi Hari Hariadi, Hari Indah Fitri Andini Judiono Judiono Jumiyati Jumiyati, Jumiyati Jumyati Jumyati Kurniawan, Maskun Kusdalinah Kusdalinah Maria Immaculata Iwo Mariati Mariati Mia Audina Miratul Haya, Miratul Misbakhul Munir Mizawati, Afrina Nispi Yulyana Nurul, Melyana Pamungkas, Barolym Tri Putra, Boy Zedra Ananda Pratama Putri, Frita Aulia Eka Refdanita Refdanita Refdanita Refdanita Rezaldi, Firman Ridhola Maharani Risda Yulianti Rizki, Gibrina Rohmatulloh, Rizal Roro Ajhie Ayuningtyas Roro Ajhie Ayuningtyas Roro Ajjie Ayuningtyas Rustam Aji Rustam Aji Rochmat Rustam Aji, Rustam Saifullah, Ipul Salsabilla, Putri sari, wina puspita Septanti, Anggriani Sherly Ratih Frichesarius Santy Aji Sherly Ratih Frichesyarius Santi Ajhie Sherly Ratih Frichesyariuss Shanty Aji Soemardji, Adreanus Andaja Sri Sumarni Stellata, Alyxia Gita Sugiono Sugiono SULISTIYANI SULISTIYANI Suratman Suseno Amin, Suseno Tamaulina Br Sembiring Teodhora, Teodhora Tetes Wahyu W Tetes Wahyu Witradharma Tetes Wahyu Witradharma Tri Handyani Utami, Umi Juarna Widiastuti, Heny Wiwiek Mulyani Yayat Sudaryat Yenni Okfrianti Yenny, Ratna Fitry YUNITA Yunita, Viona Septi Zy Khairunnisa