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All Journal HAYATI Journal of Biosciences ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar
Arsul, Muhammad Ikhlas
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : ad-Dawaa : Journal of Pharmaceutical Sciences

 1 
Formulation and Characterization of Edible Film with Concentration Various of Sodium Carboxymethyl Cellulose from Kepok Banana (Musa paradisiaca L.) Bark and Plasticizer Ningsi, Surya; Abbas, Nurfahima; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.45330

Abstract

Introduction: Bark of kepok banana (Musa paradisiaca L.) contains high cellulose that can be synthesized into sodium carboxymethyl cellulose (Na-CMC). Na-CMC can be used as a raw material for the preparation of edible film. Aims: The purpose of this study was to determine the concentration of sodium carboxymethyl cellulose from kepok banana bark combine with plasticizer to produce edible films with good characteristics and quality. Methodology: Edible films were made with varying concentrations of 6%, 10%, and 14% Na-CMC; 4% glycerol and 9% sorbitol as plasticizer. Edible films were made using casting method and characterized including organoleptic test, thickness, pH, water absorption, elongation, and tensile strength. Result: Edible film made is in the form of thin layer, transparent white in color, and odorless; thickness 0,10±0,01-0,38±0,01 mm; pH 7,1±0,08-7,7±0,04; moisture content 35,47-91,97%; elongation 16,33±3,66-53,29±6,13%; and tensile strength 0,0528±0,00-3,9871±0,04 MPa.. Conclusion: Different concentrations of Na-CMC and plasticizer affect the characteristics produced. The best result based on Japanese Industrial Standard (JIS) is formula F5 with 10% Na-CMC concentration and 9% sorbitol as plasticizer
Effects of Enhancment Span-60 of Vernonia amygdalina Leaves Extract-loaded Niosomes Pratiwi, Afrianty; Syahrana, Nur Azizah; Ismail, Isriany; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.45956

Abstract

Introdiction: Niosomes are a promising drug carrier because of their bilayer structure and the fact that they are produced by the self-association of nonionic surfactants and cholesterol in an aqueous phase. Niosomes are non-toxic, biodegradable, and compatible with human cells. Aims: This research aimed to create niosomes from V. amygdalina leaves and investigate how span 60 addition affects niosome properties. Methods: Extraction V. amygdalina using maceration, niosomes synthesized using a thin-film hydration process, and characterization performed by SEM, particle size, polydispersity index, zeta potential, and FTIR. Conclusion: V. amygdalina succesfully to loaded into niosomes. Span-60 with various concentration affected of characterization of niosomes. Increased span-60 increasing particle size, polydispersity index, and %EE.
Organic Nanoparticle Genotoxicity: Current Understanding and Future Testing Needs Sadaqa, Ebrahim; Setiawansyah, Arif; Nugroho, Bambang Hernawan; Hidayati, Nurul; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52943

Abstract

Organic nanoparticles derived from biocompatible materials like chitosan, alginate, and lipids have garnered immense interest for drug delivery, bioimaging, and other biomedical applications. However, as their use rapidly expands, a comprehensive evaluation of their potential genotoxicity is crucial to ensure safe implementation. This review provides an in-depth analysis of the genotoxic risks associated with these organic nanoparticles. The review elucidates how the unique physicochemical properties of organic nanoparticles can induce genetic damage through mechanisms such as direct DNA binding, oxidative stress, inflammation, and impairment of DNA repair pathways. Importantly, this genotoxicity can occur even in the absence of overt cytotoxicity, leading to heritable mutations and long-term adverse effects like cancer and reproductive abnormalities. A critical assessment of established and emerging genotoxicity testing methods, including their strengths, limitations, and opportunities for standardization, is presented. The review synthesizes findings from existing in vitro and in vivo studies, revealing the contrasting genotoxic profiles of different organic nanoparticle formulations and exposure scenarios. Furthermore, the review provides insights into the multifaceted factors influencing nanoparticle genotoxicity, guiding the strategic engineering of safer designs. This comprehensive analysis underscores the pivotal importance of rigorous genotoxicity screening in the responsible development of organic nanomaterials. By harmonizing their innovative capabilities with a commitment to genetic integrity, this review paves the way for realizing the vast potential of organic nanoparticles while safeguarding human and environmental health.
Toxicity and Alpha Glucosidase Inhibitory Activity of Roasted Kedawung Seed (Parkia timoriana) Supandi, Supandi; Hadi, Ismanurrahman; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57945

Abstract

Introduction: Kedawung (P. timoriana) seeds are empirically utilised as a traditional medicine; it also contains various phytochemical compounds, antioxidant activities as well as other beneficial pharmacological effects. In some regions in Indonesia, the utilisation of kedawung seeds is usually done by involving the roasting process. Aims: This study aims to investigate the effect of roasting on phytochemical compounds, toxicity and alpha glucosidase inhibitory effects. Method: Kedawung seeds were roasted at 150 ºC (15 minutes); then separated from the skin, powdered and macerated in ethanol. Result: The extract was phytochemically screened with the results obtained showing positive for saponins, flavonoids, alkaloids, and terpenoids. The following test is toxicity test using BSLT (Brine Shrimp Lethality Test) method as well as inhibitory activity on alpha glucosidase enzyme. The test results showed that kedawung extract had an LC50 of 78.18 ppm in the BSLT test, as well as inhibition of alpha glucosidase enzyme at 265.24 ppm. Conclusion: The results obtained show that the ethanol extract of roasted kedawung seeds still has phytochemical metabolite compounds, but is moderately toxic and has weak inhibition on alpha glucosidase
The Utilization of Sugarcane Waste As an Alternative Material of Halal Hard Capsules Shell Alwi, Zulfahmi; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 1 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i1.55035

Abstract

Capsules are dosage forms used to encapsulate powders, granules, pellets, liquids, and semi-solids. There are two types of capsules: soft capsules, which are usually used to encapsulate liquid and semi-solid formulas, and hard capsules, which are used to encapsulate solid formulas and non-aqueous liquids. This research aims to analyze the halal critical point of cellulose production and hard capsule shell from sugarcane waste and its handling solution, make sugarcane waste into quality halal cellulose according to pharmaceutical standards, and formulate halal cellulose into quality hard capsule shell according to pharmaceutical standards. Analyzed halal were done by material and procedure. Extraction cellulose by acetylation. Characterization of cellulose followed yield, viscosity, and swelling. Capsule shelll characterization followed size and disintegration time. This study concludes that the source of ethanol in capsule shell production is key to determining its halal status. The process must avoid using haram materials like pork, its derivatives, human body parts, khamr, blood, carrion, improperly slaughtered animals, and forbidden animals. Instead, sugarcane waste can be used to produce halal cellulose, which meets pharmaceutical standards and can be used to make hard capsule shells that are both halal and meet industry requirements.
Co-Authors Abbas, Nurfahima Afrisusnawati Rauf Arif Setiawansyah Bambang Hernawan Nugroho, Bambang Hernawan Hadi, Ismanurrahman Irda Fidrianny Isriany Ismail Jaya, Adrian Muhamad Insanu Muhammad Rifqi Abdillah Mukhriani Ningsi, Surya Nurul Hidayati Pratiwi, Afrianty Sadaqa, Ebrahim Supandi Syahrana, Nur Azizah Zulfahmi Alwi