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All Journal Jurnal Farmasi Udayana Indonesian Journal of Cancer Chemoprevention Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Indonesian Journal of Chemical Science IDJP (Indonesian Journal of Pharmaceutics) CARADDE: Jurnal Pengabdian Kepada Masyarakat FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL FARMASI GALENIKA Jurnal Ilmiah Farmako Bahari Indonesian Journal of Biological Pharmacy Jurnal Sains dan Teknologi Farmasi Indonesia Media Kesehatan Politeknik Kesehatan Makassar Jurnal Farmasi Galenika ETHOS: Jurnal Penelitian dan Pengabdian kepada Masyarakat Jurnal Kesehatan Masyarakat
Diah Lia Aulifa
Padjadjaran University
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
The Potential Use of Red Ginger (Zingiber officinale Roscoe) Dregs as Analgesic Febriani, Yessi; Riasari, Hesti; Winingsih, Wiwin; Aulifa, Diah Lia; Permatasari, Ayu
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.54 KB) | DOI: 10.15416/ijpst.v1i1.16126

Abstract

Red ginger (Zingiber officinale Roscoe) had been used as excipient in jamu for most people in Indo- nesia. Based on recent research, ethanol extract of red ginger had analgesics activity. The purpose of this research to determine analgesic activity content in water extract of the fresh and dry red ginger and ethanol extract of fresh and dry of red ginger dregs. Fresh and dry of red ginger extracted using decoc- tion method, and the dregs of fresh and dry red ginger extracted using soxhletation method in ethanol 96% at 400C. Red ginger water extract and red ginger dregs extract had been examined for analgesic by witkin method. The results showed, fresh and dry red ginger water extract had analgesic activity for 25 minutes but the activity reduced in 30 minutes. Fresh and dry red ginger dregs ethanol extract still had analgesic activity until 30 minutes. TLC chromatogram was sprayed with FeCl3 and formed two spots with grey colour for both extracts. After sprayed with vanillin sulfate, it formed violet and blue spots from both extracts. From the retention factor (Rf) , possibility shogaol and gingerol contained in extract that have analgesic activity. Key words: Analgesic, dregs, phenolic, red ginger (Zingiber o cinale Roscoe), Witkin method.
The Potential Use of Red Ginger (Zingiber officinale Roscoe) Dregs as Analgesic Yessi Febriani; Hesti Riasari; Wiwin Winingsih; Diah Lia Aulifa; Ayu Permatasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.54 KB) | DOI: 10.24198/ijpst.v1i1.16126

Abstract

Red ginger (Zingiber officinale Roscoe) had been used as excipient in jamu for most people in Indo- nesia. Based on recent research, ethanol extract of red ginger had analgesics activity. The purpose of this research to determine analgesic activity content in water extract of the fresh and dry red ginger and ethanol extract of fresh and dry of red ginger dregs. Fresh and dry of red ginger extracted using decoc- tion method, and the dregs of fresh and dry red ginger extracted using soxhletation method in ethanol 96% at 400C. Red ginger water extract and red ginger dregs extract had been examined for analgesic by witkin method. The results showed, fresh and dry red ginger water extract had analgesic activity for 25 minutes but the activity reduced in 30 minutes. Fresh and dry red ginger dregs ethanol extract still had analgesic activity until 30 minutes. TLC chromatogram was sprayed with FeCl3 and formed two spots with grey colour for both extracts. After sprayed with vanillin sulfate, it formed violet and blue spots from both extracts. From the retention factor (Rf) , possibility shogaol and gingerol contained in extract that have analgesic activity. Key words: Analgesic, dregs, phenolic, red ginger (Zingiber o cinale Roscoe), Witkin method.
Studi In Silico Potensi Antidiabetes Senyawa pada Black Garlic sebagai Inhibitor Enzim DPP-4 Sudirman, Virgiana Keisha Rajabi Johni; Priana, Diva Dhaifina Mazaya; Puspitasari, Citra Dewi; Hutapea, Ezra Calista; Muntashir, Ilham Mohammad; Pribadi, Alya Puteri Agustina; Parameswari, Natashya; Aulifa, Diah Lia
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.47506

Abstract

Diabetes mellitus merupakan penyakit kronis yang berkaitan dengan gangguan metabolisme glukosa darah. Black Garlic memiliki potensi sebagai antidiabetes karena mengandung berbagai senyawa yang dapat mengontrol kadar gula darah seperti asam fenolik, senyawa flavonoid dan S-allyl-L-cysteine (SAC). DPP-4 merupakan enzim yang berperan penting sebagai target terapeutik dari gliptin dalam pengobatan diabetes mellitus mellitus tipe II. Penelitian ini dilakukan dengan tujuan membuktikan potensi senyawa pada Black Garlic sebagai inhibitor enzim DPP-4 secara in silico melalui metode penambatan molekuler. Berdasarkan hasil penelitian, SAC memiliki nilai energi ikatan sebesar -5,36 kkal/mol dan nilai konstanta inhibisi sebesar 118,08 μM. Hal ini menunjukkan bahwa ikatan antara senyawa SAC dengan enzim DPP-4 bersifat stabil dan terbukti berpotensi sebagai inhibitor enzim DPP-4 dibandingkan keempat senyawa uji lainnya. Namun, senyawa SAC tidak lebih baik dari ligan alaminya karena memiliki nilai energi ikatan dan konstanta inhibisi yang lebih kecil. Oleh karena itu dapat disimpulkan bahwa senyawa SAC pada Black Garlic tidak lebih efektif dibandingkan dengan ligan alaminya yaitu Vildagliptin tetapi tetap dapat berpotensi sebagai inhibitor enzim DPP-4.
Co-Authors Ahsanul Haq, Fahmi Al Shofwan, Adnan Aly Almattin, Bilqis Na'ilah Alya Puteri Agustina Pribadi Angela Alysia Elaine Anggi, Joseph Fide Anisa Pebiansyah Arif Budiman Asilla Mauri Ramdini Kamaludin Audry Rahma Dewayani Augustina, Yeni Ayodduki, Zahra Noor Silmi Hermawan Ayu Permatasari Bernap Dwi Putra Sitinjak Diffa Hauna F. Pakhrul Diki Prayugo Wibowo Elaine, Angela Alysia Faizal Hermanto Febriani, Yessi Firman Firman Firman Firman Fitriansyah, Sani Nurlaela Halwa Aulia Nurdin Hesti Riasari Husna Muharram Ahadi Hutapea, Ezra Calista Izzaturrahmi, Ahda Salsabila Jutti Levita Kaila Keyshia Mei Karim, Bilqisti Kanzabila Kevin Gabriel Maria Selviana Rendo Maya Andani Muchtaridi Muchtaridi Muntashir, Ilham Mohammad Natashya Parameswari Natasya Prameswari Nurulaini, Siti Nunung Nyai Ayu Sylfia Stannia Puspitasari Helmi Nyi Mekar Saptarini Oktavia Sabetta Parameswari, Natashya Pauziah, Ai Syipa Ulfah Permatasari, Ayu Priana, Diva Dhaifina Mazaya Pribadi, Alya Puteri Agustina Puspitasari, Citra Dewi Ramadhiany, Ziyan Zulfah Resmi Mustarichie Riasari, Hesti Riezki Amalia Riki - Nugraha Rini Hendriani Rizky Prasiska Wulandari Rosandi, Nurul Fauziah Sabiq Salmandhiya Harits Salsabil Ghaliya Sani nurlaela fitriansyah Sani Nurlaela Fitriansyah Sinala, Santi Siti Uswatun Hasanah Sitinjak, Bernap Dwi Putra Sitinjak, Feggy Yustika Sitinjak, Gloria Maharyani Lastiar Sudirman, Virgiana Keisha Rajabi Johni Sunani Sunani Susy Tjahjani Swarga, Kirana Fayruz Tsamarah, Dinda Firanitha Virliana, Amrina Winingsih, Wiwin Wiwin Winingsih Yeni Augustina Yessi - Febriani Yessi Febriani Yunitasya Guspira Zahira, Annisa