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All Journal VALENSI Indonesian Journal of Applied Sciences STOMATOGNATIC- Jurnal Kedokteran Gigi Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dentino: Jurnal Kedokteran Gigi Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Kreativitas PKM Jurnal Review Pendidikan dan Pengajaran (JRPP) JPP Jurnal Kesehatan Poltekkes Palembang Indonesia Berdaya Jurnal Pengabdian Masyarakat Kebidanan Jurnal Kesehatan Gigi dan Mulut (JKGM) Denta: Jurnal Kedokteran Gigi Indonesian Journal of Dentistry Molekul: Jurnal Ilmiah Kimia Prosiding Seminar Kesehatan Masyarakat
Risyandi Anwar
Herbal Medicine Research, Department Of Pediatric Dentistry, Faculty Of Dental Medicine, University Of Muhammadiyah Semarang, Semarang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Chimica et Natura Acta

 1 
Steroid dari Kulit Batang Aglaia glabrata dan Aktivitas Sitotoksinya terhadap Sel Kanker Leukemia P-388 Risyandi Anwar; Desi Harneti; Vidia Afina Nuraini; Faizah Maira; Nurlelasari Nurlelasari; Tri Mayanti; Rani Maharani; Unang Supratman; Khalijah Awang
Chimica et Natura Acta Vol 11, No 2 (2023)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v11.n2.48980

Abstract

Steroid saponin baru, b-sitosterol-3-O-beta-D-galaktopiranosil-(1-4)-beta-D-glukopiranosida (1), bersama dengan empat steroid yang diketahui (2-5) diisolasi dari kulit batang dari Aglaia glabrata. Struktur kimia senyawa baru dijelaskan berdasarkan data-data spektroskopi. Semua senyawa diuji aktivitas sitotoksiknya terhadap sel kanker leukemia murine P-388. Diantara senyawa yang diisolasi tersebut, stigmasterol (4) menunjukkan aktivitas sitotoksik terkuat dengan nilai IC50 sebesar 12.2 mg/mL.
24-Methylenecycloartanol Isolated from The Fruit Peel of Matoa (Pometia pinnata) and Its Activity as an Antibacterial against Staphylococcus aureus and Escherichia coli Anwar, Risyandi; Arnov, Steffi Triany; Putri, Ghesta Alifka; Sinaga, Siska Elisahbet; Naini, Al Arofatus; Supratman, Unang
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.55682

Abstract

Triterpenoids are compounds with highly diverse chemical structures and exhibit interesting biological activities such as antiviral, antibacterial, anti-inflammatory, and anticancer properties. The matoa plant (Pometia pinnata), belonging to the genus Pometia from the family Sapindaceae, has been used in traditional medicine and shows potential as an antibacterial agent. The purpose of this research was to isolate and determine the chemical structure of triterpenoids from the peel of the matoa fruit (P. pinnata) and to evaluate their antibacterial activity against Staphylococcus aureus and Escherichia coli. The ethyl acetate extract from the peel of P. pinnata demonstrated significant antibacterial activity. In this study, a triterpenoid compound was identified, and its chemical structure was determined using spectroscopic methods, including UV, IR, MS, 1H-NMR, 13C-NMR, and 2D-NMR, as well as by comparing data from the literature. The compound was identified as a cycloartane-type triterpenoid known as 24-methylenecycloartanol. The compound was then tested for antibacterial activity against S. aureus and E. coli. The test results showed a minimum inhibitory concentration (MIC) of 500 μg/mL for both bacteria, which was categorized as very weak
Co-Authors Al Arofatus Naini Amiza Zam, Syarifah Nova Anisdyasarathi, Fitri Anjari, Intan Hawina Aprillia, Zita Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Suzy Puspa Pertiwi Arnov, Steffi Triany Asti, Salma Mei Darwati Darwati Delia Ilfani Desi Harneti Desi Harneti Putri Huspa Deviana Adinda Nurfatimah Dewi, Anisa Candra Erina Hilmayanti Etny Dyah Harniati Faizah Maira Farabi, Kindi Faridia Puspita Lestari Febriyani, Ita Jayanti, Lira Wiet Khalijah Awang Kindi Farabi Lilis Siti Aisyah Lisa Oktaviana Mayasari Mastura, Nurul Izzah Mayasari, Lisa Oktaviana Muhamad Nurul Azmi Naini, Al Arofatus Nikmaturrizqi, Nada Nisma Dinastiti Nisma Dinastiti Nurhidayah, Rizky Nurlelasari Nurlelasari Nurlelasari Nurlelasari Pebrian Diki Prestya Prajarini, Megawati Puspito Ratih Hardhani Putri, Ghesta Alifka Rachmawati, Ika Rani Maharani Rani Maharani Ratna Sulistyorini, Ratna Rizky Nurhidayah Samuel San Parulian Sarni Sayono Sekarningrum, Galih Prawesty Ayu Sinaga, Siska Elisahbet Siti Aminah Sofa Fajriah Steffi Triany Arnov Suaeni Kurnia Wirda Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Sutiyono, Triagus Nursasongko Tri Mayanti Tri Mayanti Tripermata, Anita Novia Tyas Nurfadlilah Amaliah Unang Supratman Vidia Afina Nuraini Yenny Febriani Yun Yoshihito Shiono