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All Journal Majalah Obat Tradisional
Ayodele, Ezekiel Temidayo
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Health Professions Medicine & Pharmacology Public Health

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Journal : Majalah Obat Tradisional

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Characterization and Identification of Novel Steroids from Nauclea pobeguinii Leaves Adepoju, Adewusi John; Oladoye, Sunday Olusegun; Ayodele, Ezekiel Temidayo; Falade, Adeola Victoria; Lim, Gin Keat; OO, Chuan Wei
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88673

Abstract

Nauclea pobeguinii is a plant in the Rubiaceae family endemic to the swamp forest region of the world. Its extract is widely used in traditional medicine for the treatment of a wide variety of ailments such as malarial, Jaundice, gonorrhea, fever, and stomach discomfort. While other parts of the plant have been examined for the bioactive principles responsible for the medicinal properties, limited information is available in the literature as regards the leaves, hence this study. N. pobeguinii leaves were collected, air-dried, and pulverized. The pulverized sample was extracted with solvents (n-hexane, ethyl acetate, and ethanol) of varying polarity to obtain the crude extracts. Repeated column and thin layer chromatographic separation of the crude extracts afforded three compounds, which were characterized by their IR, 1H, 13C-NMR, and 2D-NMR spectral data. A comparison of the data with literature confirmed the compounds to be 2-hydroxylstigmastane acetate (1), Ergosta-5,6-epoxy-22-en-3-yl-acetate (2), and β-sitosterol (3). Compounds 1 and 2 are novel to N. pobeguinii.
Co-Authors Adepoju, Adewusi John Falade, Adeola Victoria Lim, Gin Keat Oladoye, Sunday Olusegun OO, Chuan Wei