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Journal : Journal of Agropharmacy

Optimasi Gliserin dan Propilen Glikol dalam Sediaan Antioksidan Essence Ekstrak Kayu Secang (Caesalpinia sappan L.) Ameliana, Lidya; Winarti, Lina; Roja, Talidah Alqibtiyah
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1320

Abstract

Facial skin problems are often caused by skin frequently exposed to free radicals, causing damage to skin cells. Usually, skin damage is characterized by a non-smooth skin structure, the appearance of dark spots, wrinkled skin, and dull skin. Antioxidants are one of the compounds that can protect cells from the influence of free radicals and slow down or prevent the oxidation process. To help reduce, stop, and slow down the adverse effects of free radical exposure, antioxidant essence preparations are used. In this study, glycerin and propylene glycol have been optimized in the preparation of sappan wood extract essence as an antioxidant. The purpose of this study is to determine the optimum concentration of glycerin and propylene glycol as a humectant in the essence preparation of sappan wood extract. In this study, the evaluation carried out includes pH tests, viscosity, and IC 50 antioxidant activity. In this study, essence characterization tests were also carried out including organoleptics, homogeneity, and dispersibility. From the results of the pH test, it was found that all essence formulas had a pH in the range of 5.5-6.0; viscosity in the range of 1.0-2.0 dPa.s; and IC50 test of antioxidant activity in the range of 100-125 μg/mL. The optimum essence formula has a propylene glycol concentration of 10% with a desirability of 0.871, with a predicted pH value of 5.658, a viscosity value of 1.256 dPa.s, and an IC50 value of 106.473 (μg/mL).
Formulasi Krim Ekstrak Daun Kersen (Muntingia calabura L.) dan Seng Oksida Sebagai Sediaan Tabir Surya Rosyidi, Viddy Agustian; Ameliana, Lidya; maarif, safirul
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sunscreen has two types of working mechanisms, namely chemical absorber and physical blocker. Sunscreens are usually made from synthetic chemicals, but currently there are many natural ingredients that have potential as sunscreens and are believed to have little negative effect compared to synthetic chemicals. One example of a natural ingredient that has potential as a sunscreen is kersen leaves. Kersen leaves contain quite a lot of flavonoid and polyphenol compounds, therefore cherry leaves have the potential to be an antioxidant and natural sunscreen. The effectiveness of cherry leaf sunscreen can be optimized by adding a physical blocker sunscreen ingredient, namely zinc oxide. Based on research results, the in vitro effectiveness value of sunscreen cream preparations provides the best results with an SPF value of 2.193 ± 0.152 which is included in the minimal protection category with a reduction in the percentage transmission value of erythema (%TE) of 1.513 ± 0.523 which is included in the sunblock category. and the percent pigmentation transmission (%TP) value was 1,378 ± 0.325, which is included in the sunblock category.