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Journal : Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan

Uji Toksisitas Subkronik Ekstrak Etanol Biji Ketumbar (Coriandrum Sativum L.) Terhadap Fungsi Jantung Dan Paru-Paru Pada Tikus Jantan (Rattus Norvegicu.) Jennie Try Varian Laoli; Nerly Juli Pranita Simanjuntak; Finna Piska
An-Najat Vol. 2 No. 3 (2024): AGUSTUS - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i3.1530

Abstract

Coriander seed plant (Coriandrum sativum.) Apiaceae family As an alternative medicine to reduce various risk factors for heart disease including LDL cholesterol levels and high blood pressure, characterization and preparation of ethanol extract of coriander seeds (EEBK) using the maceration method was the first step in this research, followed by with subchronic toxicity testing. Subchronic toxicity testing used male rats (Rattus Norvegicu.) each of which was divided into 5 groups, namely control CMC Na 0.5%, EEBK doses of 100, 200, 400 and 500 mg/kg bw. In the subchronic toxicity test, the parameters observed included toxic symptoms, changes in body weight, death, as well as microscopic and macroscopic examination of organs, including hematological examination. This observation lasted for 28 days. Subchronic test data were analyzed using the Statistical Product and Service Solution with two-way ANOVA, followed by the Tukey and Kruskal-Wallis post-hoc test. Findings from the subchronic toxicity study indicated that EEBK did not have a toxic effect, because there was no significant difference in changes relative organ weight, body weight, number of mouse deaths, toxic symptoms, organ macroscopic, and hematological values ​​were compared with the control group (P > 0.05).
Uji Kadar Gula pada Susu Meal Replacement di Kota Medan dengan Spektofotometri UV-Vis Marini Marini; Rena Meutia; Astriani Natalia; Nerly Juli Pranita Simanjuntak
An-Najat Vol. 3 No. 2 (2025): Mei : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i2.2545

Abstract

Diabetes and obesity are closely related, with obesity as a nutritional problem that continues to increase. Obesity occurs due to an imbalance in energy intake and expenditure, while diabetes is often not realized until serious complications appear. A diet high in fiber and low in sugar can reduce the risk of diabetes. Meal replacements such as powdered milk and snack bars can be used, but consumption needs to be limited because their nutritional content is less than ideal and has the potential to cause health problems if consumed excessively. The research was carried out using quantitative and qualitative methods on 3 types of meal replacement milk powder drinks, namely brand A, brand B and brand C. This was done by collecting samples deliberately according to the inclusion and exclusion criteria, which is the sampling strategy used in this research. then research evaluation carried out 3 types of tests; Molisch's test, Benedict's test and Fehling's test. The results of the research show that the three samples of meal replacement milk circulating in the city of Medan contain sugar, but are quite safe for consumption in general and the sugar content in meal replacement milk does not exceed the daily sugar level.