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All Journal Central Publisher Jurnal ABDIMAS MUTIARA Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Natural: Jurnal Pelaksanaan Pengabdian Bergerak Bersama Masyarakat Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Intelek Insan Cendikia Galen: Jurnal Ilmu Farmasi dan Kesehatan
Eva Diansari Marbun
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Journal : Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan

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Potensi Tanaman Obat Tradisional Indonesia sebagai Agen Bio Aktif Penunjang Kesehatan Tulang Cut Massyitah Thaib; Artha Sianipar; Siti Nurbaya; Katarina Riris Teresia; Ade Irma Suryani; Eva Diansari Marbun
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1593

Abstract

Abstrak. Osteoporosis is a degenerative bone disease characterized by a decrease in bone mass and strength, particularly in postmenopausal women. Traditional plant-based therapy presents an attractive alternative given the rich local bioactive potential and limited access to pharmacological treatments. One important biochemical indicator in bone regeneration is the level of alkaline phosphatase (ALP). The aim of this study is to evaluate the potential of various Indonesian traditional medicinal plants as bioactive agents in the prevention of osteoporosis, with an emphasis on increasing ALP levels. This method employed a literature search by collecting several scientific articles discussing the anti-osteoporosis activity of traditional medicinal plants through in vitro, in vivo, and clinical observation studies. The results obtained show that traditional medicinal plants such as Turmeric (Curcuma longa), Black pepper (Piper nigrum), Bromelain (Ananas comosus), Papaya (Carica papaya), Japanese knotweed (Reynoutria japonica Houtt.), Veratrum nigrum, Sickle senna (Cassia tora), Red ginger (Zingiber officinale var. rubrum), Clove (Syzygium aromaticum L.), White turmeric (Curcuma zeadoaria), and Celery (Apium graveolens) are capable of reducing the number of osteoclasts and promoting bone formation. These findings consistently demonstrate a positive role in bone health through increased ALP levels. Indonesian traditional medicinal plants hold great potential as evidence-based anti-osteoporosis agents, particularly through enhancing ALP levels and osteoblast activity. This literature review supports the development of local herbal therapy as a promotive and preventive alternative against osteoporosis.
Co-Authors Ade Irma Suryani Adinda Nur'Sabilla Alfi Sapitri Anggi Dwi Enjelita Gultom Artha Sianipar Artha Yuliana Sianipar Aufa Azkia Candrika Candrika Candrika Catur Rafia Ningrum Christica Ilsanna Surbakti Cindirawati Putri Mora Cut Massyitah Thaib Cut Masyitah Thaib Dedi Maruli Tua Napitupulu Desni Rinanda Silitonga Devi Rahmayuni Br Harahap Devina Chandra Devina Ferisca Mawardi Dian Arisetya Dumartina Hutauruk Elfi Mardiah Ester Aura Excelsis Valentine Sihombing Fajar Pebriyandi Febriana Rianti Br Siagian Fildza Divani Fitri Maria Longga Haloho Fitri, Raissa Grace Anastasia br Ginting Immanuel Soladeo Simajuntak Intan Mawaddah Intan Putryani Gulo Jenny Arta Sari Nababan Katarina Riris Teresia Kristina Malau Lestari Gurning Lidya Nisa Auni Lisna Permata Sari Manik Manahan Situmorang Manuppak Irianto Tampubolon Maria Pratiwi Manik Modesta Harmoni Tarigan Monica Suryani Muhammad Romzi Najla Yumna Arini Nanda Fitri Nanda Nopriani Sinaga Napitupulu, Muhammad irianto Natanael Priltius Nurlaili Safitri Oktricia Eltania Zebua Puan Maharani Pertiwi Mendrofa Rahmah Indah Sari Raissa Fitri Ranisa Ranisa Retnita Ernayani Lubis Risando Sitanggang Sapitri*, Alfi Sapitri, Alfi Seprianingsih Br Silaen Sianturi, Theesyah R Sindy Yupani Br Sembiring Siti Nurbaya Sorta Partomuan Situmeang Sumingwa Sari Syukur Berkat Waruwu Theesyah R Sianturi Theesyah R. Sianturi Ulva Rizkyna Veronika Simamora Vivi Asfianti Widia Sari Widya Astuti Wiwin Katarina Sihotang Yossi Rodearni Br Manurung Yulia Larasanti Zikri Ulfata