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All Journal Jurnal Biologi Tropis JURNAL FARMASIMED (JFM) Jurnal Pengabdian kepada Masyarakat Nusantara Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Pengabdian Perawat Benzena Pharmaceutical Scientific Journal Darma Diksani: Jurnal Pengabdian Ilmu Pendidikan, Sosial, dan Humaniora Jurnal Pengabdian Masyarakat Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Ulil Albab Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
mahbub, khafid
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Pharmademica: Jurnal Kefarmasian dan Gizi

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Potensi Antioksidan Ekstrak Cangkang Kepiting Rajungan (Portunus pelagicus) dari Pekalongan, Jawa Tengah, Indonesia Ermawati, Nur; Mahbub, Khafid; Yuniarsih, Sri Mumpuni; Wiranti, Kharisma Wido; Octaviani, Felicia Aurelia
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.79

Abstract

Free radicals contribute to oxidative stress, which plays a key role in degenerative diseases. Antioxidants neutralize free radicals, preventing cellular damage. This study evaluates the antioxidant activity of Portunus pelagicus shell extract from Wonokerto, Pekalongan Regency, using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Extraction was performed through demineralization, deproteinization, and maceration with virgin coconut oil. Phytochemical analysis confirmed the presence of terpenoids, which are known for their antioxidant properties, but Thin Layer Chromatography (TLC) did not detect astaxanthin. Antioxidant activity testing at concentrations of 5, 10, 50, and 100 ppm resulted in an IC50 value of 549.40 ppm, indicating very weak antioxidant potential. The absence of astaxanthin and the weak activity may be due to extraction method limitations, solvent choice, or low concentrations of active compounds. These findings highlight the need for optimized extraction techniques to enhance the bioactive potential of crab shell-derived compounds. This study contributes to marine biowaste utilization and provides insights into improving antioxidant properties for pharmaceutical and nutraceutical applications.
Co-Authors Achada, Dina Afifah, Umul Ajeng, Miftahul Andre Kurniawan Anik Indriono Arbina Satria Afiatan Ardianto, Hery Ariqoh, Salsabila Hanifatul Ayu Wulandari Dika, Ika Vina Fatkhiya, Musa Fitri Jamiatin, Fani Julian, Rixzal Azis Larasati, Isna Mahfur, Mahfur Maulidya, Dina Achada Muhammad Walid Mutiananda, Famila Novitasari , Novitasari Nur Ermawati, Nur Octaviani, Felicia Aurelia Paramita, Adelia Rohmaniah, Salis Alyatur Sajuri Shofaro, Mulyanti Siska Rusmalina Sona, Sukma Sri Mumpuni Yuniarsih Widhowati, Siwi Sri Wiranti, Kharisma Wido Zakki, Muhammad