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All Journal HAYATI Journal of Biosciences Natural Science: Journal of Science and Technology CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) The Journal of Pure and Applied Chemistry Research JPM17: Jurnal Pengabdian Masyarakat Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Katalisator GERVASI: Jurnal Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia International Journal of Agricultural Sciences Jurnal Farmamedika (Pharmamedica Journal) Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Jurnal Kefarmasian AKFARINDO Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Insan Farmasi Indonesia Jurnal Farmasi Journal of Community Practice and Social Welfare (JaCiPS) Indonesian Community Journal JOMPA ABDI: Jurnal Pengabdian Masyarakat Lamahu: Jurnal Pengabdian Masyarakat Terintegrasi Sainsbertek Jurnal Ilmiah Sains & Teknologi Jurnal Permata Indonesia Journal of Global Pharma Technology Borneo Journal of Pharmacy Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Jurnal Kefarmasian Indonesia Khidmat: Journal Community Service
Rollando, Rollando
Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Ma Chung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Pharmaciana: Jurnal Kefarmasian

 1 
Cytotoxic effect of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione compound from the bark of faloak (Sterculia quadrifida R.Br) in breast cancer cells T47D Rollando, Rollando; Alfanaar, Rokiy
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (73.886 KB) | DOI: 10.12928/pharmaciana.v7i2.6699

Abstract

Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara for drug plant. The information of the active compound contained in the faloak bark yet specifically published. This study aims to determine the active compound contained in the faloak bark that have cytotoxic activity to T47D breast cancer cells. Extraction process using maceration method, isolation process using gradien isolation method, elusidation using combination of information of IR spectra, 1D-NMR, 2D-NMR and LC-MS, and cytotoxic activity test on T47D breast cancer cells using MTT method. The isolation result obtained that isolate of naphthoquinone derivative compound is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione with IC50 value on T47D breast cancer cell was 9,88 µg/mL and with an index selectivity value was 30,23. 
Penelusuran aktivitas antibakteri, antioksidan, dan sitotoksik fungi endofit genus fusarium sp. diisolasi dari daun meniran (Phyllantus niruri Linn.) rollando, Rollando; Aditya, Martanty; Notario, Dion; Monica, Eva; Sitepu, Rehmadanta
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.762 KB) | DOI: 10.12928/pharmaciana.v7i1.5644

Abstract

Endophytic fungi used as a new resource to produce bioactive compounds such as antibacterial, antioxidant and anticancer. This study aimed to analyze the antibacterial, antioxidant, cytotoxic fraction of the separation ethyl acetate extract of mycelium of endophytic fungi genus Fusarium sp. Diethyl ether fraction showed high antibacterial activity in E.coli (20,75 µg/mL), S.typhi (35,08 µg/mL), and S.aureus (51,96 µg/mL). Test showed that the antioxidant activity of ethanol 96% fraction has highest antioxidant activity and total phenolic content (75,85 ± 0.87 mg GAE). Cytotoxic test on T47D breast cancer cells showed that the fraction of diethyl ether have highest activity with IC50 of 10,16 ± 0,88 µg /mL.
Penelusuran aktivitas antibakteri, antioksidan, dan sitotoksik fungi endofit genus fusarium sp. diisolasi dari daun meniran (Phyllantus niruri Linn.) Rollando rollando; Martanty Aditya; Dion Notario; Eva Monica; Rehmadanta Sitepu
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.762 KB) | DOI: 10.12928/pharmaciana.v7i1.5644

Abstract

Endophytic fungi used as a new resource to produce bioactive compounds such as antibacterial, antioxidant and anticancer. This study aimed to analyze the antibacterial, antioxidant, cytotoxic fraction of the separation ethyl acetate extract of mycelium of endophytic fungi genus Fusarium sp. Diethyl ether fraction showed high antibacterial activity in E.coli (20,75 µg/mL), S.typhi (35,08 µg/mL), and S.aureus (51,96 µg/mL). Test showed that the antioxidant activity of ethanol 96% fraction has highest antioxidant activity and total phenolic content (75,85 ± 0.87 mg GAE). Cytotoxic test on T47D breast cancer cells showed that the fraction of diethyl ether have highest activity with IC50 of 10,16 ± 0,88 µg /mL.
Validation of TLC densitometry method for the quantitative determination of alkaloid in fermented endophytic fungi extract Phyllantus niruri Linn Rollando rollando; Sandra Dewi Tansil; Eva Monica; Yuyun Yuniati; Leny Yuliati
Pharmaciana Vol 9, No 1 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.619 KB) | DOI: 10.12928/pharmaciana.v9i1.11807

Abstract

Endophytic fungi can produce compound that similar with the host, so it can be  used as mass production of compound. The optimal and valid assay method is needed to obtain the proper culture condition, which one using densitometric Thin Layer Chromatography (TLC). This research used 11 samples of endophytic fungi culture extract from Phyllantus niruri within various culture condition. Optimization of mobile phase was done using 3 kinds of mobile phase mixture, chloroform: ethyl acetate: methanol (8:8:4); chloroform: ethyl acetate: methanol: NH4OH (8:8:4:0.005); chloroform:ethyl acetate:NH4OH (8:8:0.005). Validation method measured using some parameters such as linearity, accuracy, and precision. The result of optimization and validation showed that TLC densitometry method can be used for measuring alkaloid level within the endophytic fungi extract of P. niruri using chloroform: ethyl acetate: NH4OH (8:8:0.005), with R value is 0.977, percentage of recovery is between 90–110, and RSD ≤7% on each concentration series. While the proper condition of endophytic fungi culture is using sucrose as carbon source and at pH 6 condition. The content of alkaoid reached 25.9 ± 1.4 mg 100 g-1 fresh weight. 
Combination of cisplatin, Hedyotis corymbosa L. and Tinospora crispa extracts as a new therapy for breast cancer cells 4T1 through in vitro induction and cell cycle modulation Rollando Rollando; Muhammad Hilmi Afthoni
Pharmaciana Vol 10, No 1 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (123.796 KB) | DOI: 10.12928/pharmaciana.v10i1.14060

Abstract

Cisplatin is a chemotherapeutic agent with varying side effects. Berberine compounds in Tinospora crispa and ursolic acids in Hedyotis corymbosa L are known to have high cytotoxic activities. This study was aimed to examine the effects of the combination of cisplatin, the ethanolic extract of Hedyotis corymbosa L.(EEHC), and the ethanolic extract of Tinospora crispa roots (EETC) on enhanced breast cancer cell sensitivity by apoptotic induction and cell cycle modulation. Cytotoxic effects were tested using the MTT assay in breast cancer cells, 4T1. The combination test of cisplatin and the extracts yielded combination index (CI) and cell viability, and its effects on the induction of apoptosis and cell cycle modulation were observed by the flow cytometry method. The results of the cytotoxic test showed CI of less than one for 1 mg/mL EEHC, 6 mg/mL EETC, and 1.68 mg/mL cisplatin. The EEHC-EETC-cisplatin combination accumulated cells in the S phase (29.98%) and induced apoptosis in 4T1 cells. It proves that EEHC and EETC can be developed as co-agents with cisplatin to improve the effectiveness of breast cancer chemotherapeutic treatment.
Cytotoxic effect of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione compound from the bark of faloak (Sterculia quadrifida R.Br) in breast cancer cells T47D Rollando Rollando; Rokiy Alfanaar
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (73.886 KB) | DOI: 10.12928/pharmaciana.v7i2.6699

Abstract

Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara for drug plant. The information of the active compound contained in the faloak bark yet specifically published. This study aims to determine the active compound contained in the faloak bark that have cytotoxic activity to T47D breast cancer cells. Extraction process using maceration method, isolation process using gradien isolation method, elusidation using combination of information of IR spectra, 1D-NMR, 2D-NMR and LC-MS, and cytotoxic activity test on T47D breast cancer cells using MTT method. The isolation result obtained that isolate of naphthoquinone derivative compound is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione with IC50 value on T47D breast cancer cell was 9,88 µg/mL and with an index selectivity value was 30,23. 
Co-Authors Ade Irene Beactris Saudale Adi Hermansyah, Adi Adi Sofyan Ansori, Muhammad Aini, Nur Sofiatul Alfanaar, Rokiy Arum Ardanareswari Atarodang Beatrico Lyo Ayu Merli Wahyuni Aziz, Nur Bella Vania Sianto Benedictus Karel Bezhinar, Tatyana Burkov, Pavel Chandra, Melisa Dwi Charina Halim Sugiono Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Christopher Daniel Kurniawan Collins, Ellen Derkho, Marina Dhita Rizki Amalia Dion Notario Dion Notario Dodi Iskandar Dodi Iskandar, Dodi E. Monica Eka Anggie Amalia Eka Anggie Amalia Erizcha Debora Embang Erlinawati Santoso Erlinawati Santoso Eva Monica Eva Monica Eva Monica Eva Monica, Eva F.X. Haryanto Susanto Fauziya Radani Fibe Yulinda Cesa FX Haryanto Susanto FX Haryanto Susanto Godeliva Adriani Hendra Gudz, Petr Gytha Novella Ongkowijoyo Herdiansyah, Mochammad Aqilah Hery Purnobasuki Ichsan Ichsan Indriani Nuraini Widya Ismaurasi, Marcelina Fransisca Alecia Kestrilia Rega Prilianti Khairullah, Aswin Rafif Kharisma, Viol Dhea Kotimah, Chusnul Leny Yuliati M. H. Afthoni Maksimiuk, Nikolai Maria Sindy Marsha Anggita Amelia Martanty Aditya, Martanty Masruri Masruri Masruri Masruri Maywan Hariono Mifta Devin Suwandi Monica, Eva Muhammad Hilmi Afthoni Muhammad Setiyawan Munawir Sazali Murtadlo, Ahmad Affan Ali Nashi Widodo Nashi Widodo Natanael Anugerah Tuuk Natan Nugraha, Dhanang Prawira Nurmiati Nurul Azmi Wibawanty P. N. Alfiyandri Paulina Genoveva Moza Pramesti, Agatha Tri Endha Rahadi, Theresa Dhea Lonika Raharja, Albert Rebezov, Maksim Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadenta Sitepu Renata Hadi Resha Ramadhania Rino Tam Cahyadi, Rino Tam Ririn Nurdiani Ririn Nurdiani Ruth Febriana Kesuma Sabrina Handayani Tambun Sandra Dewi Tansil Setiawan, Hendry Siswadi Siswadi Sitepu, Rehmadanta Sitepu, Rehmadanta Sophia Yusnita Wahyu Timur Sophia Yusnita Wahyu Timur Sri Hardyastutik Sugiono, Charina Halim Suharyani Amperawati Susana Susana Susanto, F.X Haryanto Susanto, FX. Haryanto Teguh Hari Sucipto, Teguh Hari Trianom Suryandharu W. Swastika Wahyu Timur, Sophia Yusnita Warsito Warsito Warsito Warsito Widyananda, Muhammad Hermawan Windra Swastika Windra Swastika Y. Erning Indrastuti Yandriyani, Devilke Yanuar, Michael Resta Surya Yuni Purwaningdiah Yuniati, Yuyun Yurida Ekawati Yurida Ekawati