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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences BIOTROPIA - The Southeast Asian Journal of Tropical Biology AL KAUNIYAH Dentika Dental Journal Biotropika JURNAL PENGABDIAN KEPADA MASYARAKAT Chimica et Natura Acta Jurnal Mikologi Indonesia Meditory : The Journal of Medical Laboratory Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Biosaintifika: Journal of Biology & Biology Education Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Scripta Biologica JURNAL ILMIAH KESEHATAN SANDI HUSADA Abdi Dosen : Jurnal Pengabdian Pada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) Jurnal Pengabdian Masyarakat Indonesia Solidaritas: Jurnal Pengabdian Jurnal Bina Cipta Husada: Jurnal Kesehatan dan Science Molekul: Jurnal Ilmiah Kimia KOPEMAS Jurnal Ilmiah Kesehatan Sandi Husada
Nuniek Ina Ratnaningtyas
Fakultas Biologi, Universitas Jenderal Soedirman, Purwokerto
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Molekul: Jurnal Ilmiah Kimia

 1 
Anti-inflammatory and immunosuppressant activity of Coprinus comatus ethanol extract in carrageenan-induced rats (Rattus norvegicus) Nuniek Ina Ratnaningtyas; Fajar Husen; Hernayanti Hernayanti; Nuraeni Ekowati; Bambang Heru Budianto
Molekul Vol 17 No 3 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.3.5815

Abstract

oprinus comatus (O.F. Mull.) is an edible mushroom that is used as an anti-inflammatory agent. Therefore, this study aims to determine the effect of inflammation treatment on symptoms alleviating, function maintenance, and inhibiting the process of tissue damage due to an increase in free radicals using drug formulations with high antioxidant compounds. This is a true experiment conducted using a Completely Randomized Design (CRD) with a post-test and a control group. The rats were divided into 6 categories, which include 1 healthy and 5 groups induced with 1% carrageenan. Out of the treatment groups, 3 were treated with ethanol extract of C. comatus fruiting body at doses of 250 (T1), 500 (T2), and 750 mg/kg BW (T3), 1 received diclofenac sodium (PC) and the other as a negative control (NC), were given extract for 14 days and induced with 0.5 mL carrageenan in paw of rats at day 15. The qualitative identification showed the extracts contains flavonoid, polyphenol, alkaloid, triterpenoid, steroids and saponins, and GC-MS analysis showed 10 putative metabolites compound. T2 group significantly decreased the levels of IL-1β (70.63%), IgE (59.04%), total leukocyte count (31.24%), plantar thickness (12.5%), edema volume (33.3%), and increased endothelial NO levels (48.2%).
Detoxification of Cadmium on Albino Rats (Rattus norvegicus) with Natural Chelator of Fruiting Body Extract of Ganoderma lucidum Hameda Dhaka Kusuma Taufiq; Hernayanti Hernayanti; Nuniek Ina Ratnaningtyas
Molekul Vol 18 No 1 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.1.5844

Abstract

Cadmium is a heavy metal pollutant sourced from various industries and toxic to the kidneys. Cadmium exposure can be used natural chelator of ethanol extract of the fruiting body of Ganoderma lucidum. The aim of the study was to determine the effect and effective dose of the ethanolic extract of the fruiting body of G. lucidum on reducing the toxicity effect of cadmium in male albino rats (Rattus norvegicus) Wistar strain. The research design was experimental research, which consisted of 5 treatment levels. The research parameters were blood cadmium, β2-microglobulin, malondialdehyde, and superoxide dismutase levels. The ethanolic extract of fruiting body of G. lucidum was tested by gas chromatography-mass spectrometry (GCMS) to determine linalool as active compounds. The results of each parameter had a significant effect, which decreased blood cadmium, β2M and MDA levels, and increased SOD level that linear according to the addition of the dose of ethanol extract of the fruiting body of G. lucidum. Blood cadmium levels with β2M and MDA levels had a positive correlation, while blood cadmium levels with SOD levels had a negative correlation. The dominant compound detected was linalool which has potential as a radical scavenger. The dose of 750 mg.kgBW-1 is the effective dose of the ethanolic extract of fruiting body of G. lucidum based on a decrease in blood cadmium levels (54.10%), β2M (63.94%) and MDA (20.31%), as well as an increase in SOD levels (14.20%) compared to sick control.
Co-Authors . HERNAYANTI AA Sudharmawan, AA Adi Supriyadi Agus Hery Susanto Agus Irianto Aisyah Tri Septiana Aisyah Tri Septiana Amalia Sofia Maharani Amelia, Aurora Pradipta Ana Yulia Andarwanti, Suci angelin marhavyna cristy Anik Laeli Perdanawati Apriyani, Tri Rahayu Ari Asnani Arif Rahman Hikam Aris Mumpuni Ashar, Fadli Atik Retnowati Azhar Faturohman Abidin Azizah, Enur Bahrun Bahrun Bambang Heru Budianto Budiarti, Vio Indah cristy, angelin marhavyna Dalia Sukmawati Daniel Joko Wahyono Dattadewi Purwantini Dhea Rifa Rahmah Edyawati Dian Islamiyati Dian Islamiyati Dini Ryandini Dini Ryandini Dody Novrial, Dody Doso Sarwanto Dyah Fitri Kusharyati Eko Setio Wibowo Ellen Evita Endang Sri Purwanti Endang Sri Purwanti Endang Sri Purwati Endang Sri Purwati Endang Sukara Evita, Ellen Fajar Husen Feryawan Feryawan Feryawan, Feryawan Fitria Dewi Sulistiyono Fitrianto, Nur Fitriya Yuni Wulandari Haris Budi Widodo Herliana, Okti Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti HERNAYANTI HERNAYANTI Irfan Dwiandhono Isnaini Maulida Juni Safitri Muljowati Juni Safitri Muljowati Khasanah, Nur Aini Hidayah Kurniawan Kurniawan Loekas Soesanto Loekas Soesanto Maharani, Amalia Sofia Maria Mardhitama Maharani MU'AFA, RAFID HILMY Muntahanah, Siti Nahdatulia, Yasinta Nawangtantrini, Gita Ningrum, Ema Wahyu Noverita Nur Aini Hidayah Khasanah Nur Aini Hidayah Khasanah Nur Fitrianto Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati, Nuraeni Nuraini Hidayah Khasanah Oedjiono P.M. Hendrati Palindung, Lusia Seti Perdanawati, Anik Laeli Purnomowati Purnomowati Purnomowati Purnomowati, Purnomowati Purwanto Bekti Santoso, Purwanto Bekti Ratna Stia Dewi Ratri Noor Hidayah Riama Kustianingrum Rifda Naufalin Rizki Maulida Ross Nurul Rohmah Ryan Firman Syah Salamiah Salamiah Saputra, Wahyu Dwi saraswati, esti Siti Samiyarsih Siti Samiyarsih Siti Samiyarsih Slamet Priyanto Sri Hartini Sri Lestari Sri Lestari Suci Andarwanti Supriyadi, Adi Taufiq, Hameda Dhaka Kusuma Tri Rahayu Apriyani Tyas Retno Wulan Ulfa Fadila Rudatiningtyas Ulfa Fadilla Rudatiningtyas Utami, Nurani Ajeng Tri Vika Vidiyanti Vio Indah Budiarti Wahyu Dwi Saputra Wirakhmi, Ikit Netra Witiyasti Imaningsih Yanita Mutiaraning Viastika Yuniati, Nilasari Indah Yunida Triana, Noor Zahra, Jauza Ulya