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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences BIOTROPIA - The Southeast Asian Journal of Tropical Biology AL KAUNIYAH Dentika Dental Journal Biotropika JURNAL PENGABDIAN KEPADA MASYARAKAT Chimica et Natura Acta Jurnal Mikologi Indonesia Meditory : The Journal of Medical Laboratory Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Biosaintifika: Journal of Biology & Biology Education Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Scripta Biologica JURNAL ILMIAH KESEHATAN SANDI HUSADA Abdi Dosen : Jurnal Pengabdian Pada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) Jurnal Pengabdian Masyarakat Indonesia Solidaritas: Jurnal Pengabdian Jurnal Bina Cipta Husada: Jurnal Kesehatan dan Science Molekul: Jurnal Ilmiah Kimia KOPEMAS Jurnal Ilmiah Kesehatan Sandi Husada
Nuniek Ina Ratnaningtyas
Fakultas Biologi, Universitas Jenderal Soedirman, Purwokerto
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Dentika Dental Journal

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The Effect Of Ethanol Extract From Lingzhi Fungi (Ganoderma Lucidum) Cianjur Isolate On Syndecan-1 Expressions In Kb CCL17 Oral Cancer Cell: Efek Ekstrak Ethanol Dari Jamur Lingzhi (Ganoderma Lucidum) Isolat Cianjur Terhadap Ekspresi Syndecan-1 Pada Sel Kanker Rongga Mulut Kb Ccl-17 Ashar, Fadli; Widodo, Haris Budi; Wahyono, Daniel Joko; Ratnaningtyas, Nuniek Ina; Nawangtantrini, Gita; Novrial, Dody; Dwiandhono, Irfan
Dentika: Dental Journal Vol. 24 No. 2 (2021): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v24i2.4189

Abstract

Intercellular adhesion plays a role in cancer formation and protein has a key potential in maintaining cell adhesion, including syndecan-1. Meanwhile, oral cancer originates from the oral epithelium, which has an invasive and metastatic level. Its treatments involving chemotherapy and radiotherapy commonly leave unfavorable side effects, hence, suitable alternatives are needed. Natural ingredients are widely used as an alternative treatment for cancer, for example, Ganoderma lucidum (G. lucidum) which has anti-cancer and anti-angiogenic properties, induces apoptosis, stimulates an immune response, inhibits the degradation of Extracellular matrix (ECM), reduces inflammation, affects cell cycles, cytotoxic, and acts as an antioxidant.This study aims to determine the effect of ethanol extract from Ganoderma lucidum Cianjur isolate on syndecan-1 expression in KB CCL-17 oral cell cancer. This was an experimental study with a post-test only control group design, the treatment group used G. lucidum ethanol extract with a concentration of 2.12 μg/ml (P1), 4.24 μg/ml (P2), and 8.49 μg/ml (P3), while the positive control group used cisplatin with a concentration of 11.5 μg/ml (K1). In contrast, the negative control used aquadest (K0), while syndecan-1 expression was observed using the immunohistochemical examination.The highest syndecan-1 expansion rate was found in the treatment group with a concentration of 8.49 μg/ml. A significant difference was indicated by one-way ANOVA (p<0.05) between K0 - K1, K0 - P1, K0 - P2, K0 - P3, K1 - P1, K1 - P2, K1 - P3, P1 - P2, as well as P1 and P3. The administration of ethanol extract from G. lucidum Cianjur isolate increases syndecan-1 expression in KB CCL-17 oral cell cancer.
Co-Authors . HERNAYANTI AA Sudharmawan, AA Adi Supriyadi Agus Hery Susanto Agus Irianto Aisyah Tri Septiana Aisyah Tri Septiana Amalia Sofia Maharani Amelia, Aurora Pradipta Ana Yulia Andarwanti, Suci angelin marhavyna cristy Anik Laeli Perdanawati Apriyani, Tri Rahayu Ari Asnani Arif Rahman Hikam Aris Mumpuni Ashar, Fadli Atik Retnowati Azhar Faturohman Abidin Azizah, Enur Bahrun Bahrun Bambang Heru Budianto Budiarti, Vio Indah cristy, angelin marhavyna Dalia Sukmawati Daniel Joko Wahyono Dattadewi Purwantini Dhea Rifa Rahmah Edyawati Dian Islamiyati Dian Islamiyati Dini Ryandini Dini Ryandini Dody Novrial, Dody Doso Sarwanto Dyah Fitri Kusharyati Eko Setio Wibowo Ellen Evita Endang Sri Purwanti Endang Sri Purwanti Endang Sri Purwati Endang Sri Purwati Endang Sukara Evita, Ellen Fajar Husen Feryawan Feryawan Feryawan, Feryawan Fitria Dewi Sulistiyono Fitrianto, Nur Fitriya Yuni Wulandari Haris Budi Widodo Herliana, Okti Hernayanti Hernayanti HERNAYANTI HERNAYANTI Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti Hernayanti Irfan Dwiandhono Isnaini Maulida Juni Safitri Muljowati Juni Safitri Muljowati Khasanah, Nur Aini Hidayah Kurniawan Kurniawan Loekas Soesanto Loekas Soesanto Maharani, Amalia Sofia Maria Mardhitama Maharani MU'AFA, RAFID HILMY Muntahanah, Siti Nahdatulia, Yasinta Nawangtantrini, Gita Ningrum, Ema Wahyu Noverita Nur Aini Hidayah Khasanah Nur Aini Hidayah Khasanah Nur Fitrianto Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati Nuraeni Ekowati, Nuraeni Nuraini Hidayah Khasanah Oedjiono P.M. Hendrati Palindung, Lusia Seti Perdanawati, Anik Laeli Purnomowati Purnomowati Purnomowati Purnomowati, Purnomowati Purwanto Bekti Santoso, Purwanto Bekti Ratna Stia Dewi Ratri Noor Hidayah Riama Kustianingrum Rifda Naufalin Rizki Maulida Ross Nurul Rohmah Ryan Firman Syah Salamiah Salamiah Saputra, Wahyu Dwi saraswati, esti Siti Samiyarsih Siti Samiyarsih Siti Samiyarsih Slamet Priyanto Sri Hartini Sri Lestari Sri Lestari Suci Andarwanti Supriyadi, Adi Taufiq, Hameda Dhaka Kusuma Tri Rahayu Apriyani Tyas Retno Wulan Ulfa Fadila Rudatiningtyas Ulfa Fadilla Rudatiningtyas Utami, Nurani Ajeng Tri Vika Vidiyanti Vio Indah Budiarti Wahyu Dwi Saputra Wirakhmi, Ikit Netra Witiyasti Imaningsih Yanita Mutiaraning Viastika Yuniati, Nilasari Indah Yunida Triana, Noor Zahra, Jauza Ulya