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All Journal Jurnal Penelitian Farmasi dan Herbal Journal of Pharmaceutical and Sciences.
Umaya, Chindy
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BONGGOL BROKOLI (Brassica oleracea L. var. Italica) DENGAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazy) Umaya, Chindy; Marbun, Nova Rianti; Br Sembiring, Tio Ranti Sari
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2732

Abstract

Broccoli (Brassica oleracea L. var. Italica) is a vegetable recognized for its abundant bioactive components, such as flavonoids, tannins, saponins, and vitamin C, which are linked to antioxidant capabilities. Notwithstanding its health advantages, the broccoli stalk is frequently disregarded and underexploited, despite its potential as a source of natural antioxidant chemicals. This work aims to assess the antioxidant activity of the ethanolic extract from broccoli stalks utilizing the DPPH method and to ascertain its IC₅₀ value. The extraction was conducted via the maceration method utilizing 70% ethanol, and the antioxidant activity was assessed through UV-Vis spectrophotometry at a peak wavelength of 516 nm. The results indicated that the ethanolic extract of broccoli stem possesses considerable antioxidant activity, with an IC₅₀ value of 35.74 µg/ml. The IC₅₀ value of vitamin C was shown to be 7.67 µg/ml. The results indicate that broccoli stalks may be a significant source of natural antioxidants. The validation of the analytical method demonstrated outstanding results, including linearity (r = 0.9989), accuracy (100.57%), and precision (%RSD = 0.5646%).
Perbandingan aktivitas antidiabetes ekstrak air dan etanol Muntingia calabura L Folium terhadap mencit jantan Pangondian, Aswan; PS, Nurunnisa; Husein, Saddam; Umaya, Chindy; Athaillah, Athaillah; Chandra, Putra
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.461

Abstract

Muntingia calabura L is an Indonesian herbal plant known as kersen which has the ability to reduce blood sugar levels. M. Calabura has secondary metabolites, namely flavonoids, tannins, triterpenoids, saponins and polyphenols. This study aimed to compare the antidiabetic activities of water and ethanol extracts of M. calabura in male mice. In this study, M. calabura was extracted using the maceration method with 70% ethanol solvent (EEMC) and decoction of Kersen leaves (EDMC). Blood glucose levels were measured at intervals of 15, 30, 45, and 60 minutes using a glucometer after being induced by alloxan induction. Animals were divided into eight groups (positive group, negative group and EEMC group, and EDMC group with doses of 125, 250 and 500 mg/kg BW. The results of the investigation showed that the activity to reduce blood glucose levels during the interval time was significantly different compared to the negative group, and positive control was not significantly different compared to the EEMC 250 mg/kg BW and EDMC 500 mg/kg BW groups. The conclusion of this study was that the EEMC and EDMC groups had decreased blood glucose levels. EEMC 250mg/kg BW and EDMC 500 mg/kg BW groups showed comparable activity to the positive control.
Co-Authors Athaillah, Athaillah Br Sembiring, Tio Ranti Sari Chandra, Putra Marbun, Nova rianti Pangondian, Aswan PS, Nurunnisa Saddam Husein, Saddam