Background: Good performance is the dream of every hospital which aims to achieve the predeter¬mined vision, mission and goals. Achieving the vision, mission and goals requires human resources who are capable of handling these matters. This study aimed to determine and analyze the deter¬mi¬nants of the performance of health and non-health workers.Subjects and Method: Cross-sectional study was conducted at Dr. Soediran Mangun Suwarso Hospital, Wonogiri, Central Java, from November to December. 200 hospital workers were selected using stratified random sampling. The dependent variable was work performance. The independent variables were work motivation, job satisfaction, job training, work environment, and job suitability. Data was collected using a questionnaire and analyzed using a path analysis model.Results: Performance of hospital employers was directly and positively influenced by job satisfaction (b= 0.15; 95% CI= 0.01 to 0.28; p = 0.033), work motivation (b= 0.17; 95% CI = 0.04 to 0.31; p= 0.009), and training (b= 0.16; 95% CI= 0.03 to 0.29; p= 0.017). Satisfaction increased motivation (b= 0.83; CI 95%= 0.54 to 1.12; p <0.001). Job satisfaction was influenced by the work environment (b= 0.13; CI 95%= 0.02 to 0.23; p= 0.016) and job suitability (b = 0.41; 95% CI= 0.30 to 0.51; p <0.001).Conclusion: Performance of hospital employers is directly and positively influenced by job satisfaction, work motivation, and training. Satisfaction increases motivation. Job satisfaction is influenced by the work environment and job suitability.