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All Journal SAINSMAT Jurnal Kreatif Tadulako Online Jurnal Pendidikan Biologi Indonesia QUANTUM: Jurnal Inovasi Pendidikan Sains Indonesia Chimica Acta JOIV : International Journal on Informatics Visualization Jurnal Penelitian Pendidikan IPA (JPPIPA) Jambura Journal of Educational Chemistry Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Diseminasi : Jurnal Pengabdian kepada Masyarakat Journal of Applied Science, Engineering, Technology, and Education Journal On Teacher Education (Jote) Jurnal Pengabdian kepada Masyarakat Nusantara SPIN: Jurnal Kimia & Pendidikan Kimia Mattawang: Jurnal Pengabdian Masyarakat JINAV: Journal of Information and Visualization Quantitative Economics and Management Studies Panrannuangku Jurnal Pengabdian Masyarakat EduLine: Journal of Education and Learning Innovation Daengku: Journal of Humanities and Social Sciences Innovation ARRUS Journal of Mathematics and Applied Science SAINSMAT: Journal of Applied Sciences, Mathematics, and Its Education Media Eksakta Journal of Disruptive Learning Innovation (JODLI) al-fikrah: Jurnal Manajemen Pendidikan Satwika: Jurnal Pengabdian kepada Masyarakat SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam Arfak Chem: Chemistry Education Journal ATHENA: Journal of Social Culture and Society Tadibia Islamika: Journal of Holistic Islamic Education Tatar Pasundan: Jurnal Diklat Keagamaan Al-khidmah: Jurnal Pengabdian dan Pendampingan Masyarakat SEARCH: Science Education Research Journal of Education, Social & Communication Studies Golden Age and Inclusive Education EDUTREND: Journal of Emerging Issues and Trends in Education Journal of Chemistry Sciences and Education
Dewi Satria Ahmar
Department Of Chemistry Education, Faculty Of Teacher Training And Education, Tadulako University, Palu, Indonesia
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Journal : Indonesia Chimica Acta

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Pharmacology Analysis of The Active Compound of Makassar Fruit (Brucea Javanica) as Antidiabetic Via Bioinformatics Approach Arwansyah Arwansyah; Vivi Dia A Sangkota; Dewi Satria Ahmar; Magfirah Magfirah; Karina Nadya Sirajuddin; Adwi Restafara; Abdur Rahman Arif
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 15, No 2: December 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v15i2.21043

Abstract

Diabetes is one of the emergency diseases worldwide due to the large case each year. Therefore, searching the potential treatment become crucial to treating the disease. In this research, homology modeling and molecular docking were employed to analyze the active compounds of Makassar fruit (Brucea javanica) as antidiabetic. Alpha glucosidase (AG) is used as a target, and the ligands are javanicin and javanicisode B, both active molecules of Brucea javanica. According to molecular docking results, all ligands have the potential to bind to the receptor because of their negative energy scores. Also, javanicin has higher binding energy (-8.0 kcal/mol) than the control (-5.7 kcal/mol). Furthermore, hydrogen bonds and hydrophobic interactions allow these two active chemicals to attach to an important location on AG. Thus, our finding implied that two active compounds of Brucea Javanica could be inhibitors for the receptor, and javanicin may become a promising drug against diabetes.
Co-Authors Aan Febriawan Abdul Kamaruddin Abdur Rahman Arif Aceng Haetami, Aceng Adwi Restafara Afadil Agus Nasir Agus Nasir, Agus Agussatriana Ahmad Kadir Kilo Ahmar, Ansari Saleh Alifa, Nur Alifta Alifta Alimuddin Alimuddin Anang Wahid M.Diah Andi Saadillah Anggreni, Afrillia Anggriani, Windi Arwansyah Arwansyah Arwansyah Ayu Kusumawati Ayu Rahayu Ayu Rahayu Azzajjad, Muhammad Fath Dewi Natalia Marpaung Dian Permana Eko Hariyadi H Halima Hanisa, Siti Haris Munandar Hayyatun Mawaddah Hijrinia Kusumaning Ayu Ifriana, Ifriana Ilimu, Edi Iyan Nurdiyan Haris Jamaludin M Sakung Jesi Jecsen Pongkendek Jesi Jecsen Pongkendek Jesi Jecsen Pongkendek Karina Nadya Sirajuddin Kasmudin Mustapa Lilies N Tangge Magfirah Magfirah Magfirah Magfirah Magfirah Magfirah, Magfirah Manalu, Yessi Febianti Mardiana Marpaung, Dewi Natalia Metoli, Erwin Priscal Miswandi Tendrita Mohammad Jamhari Muh. Syahrir Muhammad Ismail Muhammad Ismail Muhammad Zikra Musdalifatul Adewia Neks Triani Nur Anisa Nur Jannah Baturante Nurfadila, Safna Nurfianti Pathuddin Patmasari, Andi Poba, Detris Pongkendek, Jesi Jecsen Purnama Ningsih Rahman, Nurul Aulia Rahmatia, Sitti Ratman Ratman Ratman Riadhatul Ulum Rizki, Nur Riani Roy Kulyawan Ruslin Hadanu Sangkota, Vivi Dia A. Sari, Nurita Sari, Sintya Puspita Sely Artasasta Lawongo Siti Nuryanti Sitti Rahmatia Sitti Rahmawati Sri Hastuti Virgianti Pulukadang Sri Muliani, Sri Sri Mulyani Sabang Sudir Umar Suherman Suherman, Suherman sukmawati Sukmawati Sukmawati Supriadi Supriadi Syafitri, Dhini Syahrir, Muh. Tonio, Sarinah Emilia Tri Santoso Tri Santoso Tri Santoso Tukaedja, Sindi Velesia Vivi Dia A Sangkota Wahab, Zamil Wilda Utami WINARSIH Yasin, Yusril Zulkifli Zulkifli