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All Journal Jurnal Farmasi Klinik Indonesia MITRA: Jurnal Pemberdayaan Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Narra J Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Journal of Urban Health Research
Cokro, Fonny
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Ilmu Kefarmasian Indonesia

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Efektivitas Flukonazol dalam Mencegah Infeksi Jamur Invasif pada Bayi dengan Berat Lahir Sangat Rendah: Tinjauan Sistematis dan Meta-analisis Fonny Cokro; Lorensia Yolanda; Shelly Caroline
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1035

Abstract

Fungal infections in neonates, especially in Very Low Birth Weight (VLBW) infants, are mostly caused by Candida species and may lead to morbidity and mortality. A systematic review and a meta-analysis were conducted to determine the extent to which fluconazole, an antifungal prophylactic, was effective and safe to use in VLBW or premature infants in preventing Invasive Fungal Infection (IFI), by including Randomized Controlled Trials (RCTs) carried out worldwide. The investigation started with searching process through publication databases: MEDLINE, Cochrane, ScienceDirect, and Garuda, for Randomized Controlled Trials (RCTs) that compared the prophylactic effects of fluconazole and placebo on IFI in VLBW infants. The selected eight RCT studies indicated that, compared to placebo, fluconazole accounted for 68% risk reduction of overall fungal colonization (RR=0.32; 95% confidence interval [CI]=0.24-0.42, p=0.00001, I-square=0%) and 60% risk reduction of IFI (RR=0.40; 95%[CI]=0.22-0.72, I-square=56%, p=0.002). However, fluconazole did not significantly reduce mortality in VLBW infants (RR=0.79; 95%[CI]=0.60-1.03; p=0.08, I-square=0%). Also, regarding its safety, fluconazole prophylaxis did not result in significant elevations of SGOT/SGPT levels (RR=1.22; 95%[CI]=0.50-3.00, p=0.66, I-square=0%) nor cause intestinal perforation (RR=0.96; 95%[CI]=0.25-3.68, p=0.96, I-square=59%). Fluconazole is an effective prophylaxis agent against invasive fungal infection when given to preterm infants with birth weight <1500, but not proven in reducing the mortality incidence in VLBW infants.
Co-Authors Abdul Rahem Abdul Rahem, Abdul Agnes Anania Triavika Sahamastuti Agustina Dwi Retno Nurcahyanti Andrelia, Evelyn Trisia Anton Sumarpo Arrang, Sherly Tandi Dion Notario Erlia Anggrainy Sianipar Evi Martha Felicia Christian Franciscus C. Kristianto Genoveva Della Gokok, Silvia Gunawan, Catherine Keiko Heri setiawan Jap, Adeline Jenny Jokimawidjaja Jonathan A. N. Solang Kristianto, Franciscus C. Lady, Jullietta Lisa Aditama, Lisa Lorensia Yolanda Meilani Eka Putri Nathacia Nathacia Pangestuning Sekarsari Pattirajawane, Ignatius Danny Rani Sauriasari, Rani Sagala, Reynelda Juliani Shelly Caroline Sherly T. Arrang Tahapary, Dicky L. Yolanda, Lorensia