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All Journal Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Nusantara Scientific Medical Research Journal Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains Farmasi dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Erida Novriani
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Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Journal : Galen: Jurnal Ilmu Farmasi dan Kesehatan

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Formulation of Abelmoschus manihot Leaf Gel Using Carbopol and HPMC and Antibacterial Activity Against Pseudomonas aeruginosa Christina Amelia; Nerly Juli Pranita Simanjuntak; Erida Novriani
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 2 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i2.18

Abstract

Diabetic foot ulcers are a chronic complication commonly experienced by patients with diabetes mellitus, often caused by Pseudomonas aeruginosa, a pathogenic bacterium with high antibiotic resistance. This study aimed to evaluate the effect of varying concentrations of Carbopol 940 and HPMC bases on the physical characteristics and antibacterial activity of gedi leaf (Abelmoschus manihot) extract gel preparations. The extract was obtained through maceration using 70% ethanol. The gel was formulated into six different formulas: three with HPMC (1%, 2%, and 3%) and three with Carbopol 940 (0.5%, 1%, and 2%), each containing 10% extract. Evaluations included physical characteristics (organoleptic properties, homogeneity, pH, viscosity, spreadability, and stability) and antibacterial activity against P. aeruginosa using the disk diffusion method. The results showed that all formulas met acceptable physical parameters. One-way ANOVA revealed a statistically significant difference in inhibition zone diameters among the formulas (p < 0.001). The formula containing 1% Carbopol exhibited the largest inhibition zone, indicating the most effective antibacterial activity against P. aeruginosa. These findings suggest that gedi leaf extract gel has promising potential as an alternative topical therapy for diabetic foot infections.
Co-Authors Amazihono, Keytrin Arbita Huri Asyrun Alkhairi Lubis Christina Amelia Cut Inssy Mulun Devortivo Hartono Putra Ega Yos Sanda Gerhart Frengki Hardian Harefa Hariyadi Dharmawan Syahputra Lubis, Asyrun Alkhairi Monica Silviyana Simbolon Muhammad Yunus Nerly Juli Pranita Simanjuntak Puput, Puput Virgia Ningrum Razoki Razoki Razoki Razoki, Razoki Rika Mai Dinasari Br Sembiring Simanjuntak, Nerly Juli Pranita Stefanus Rio Pendamenta Tarigan Tasya Melisa Br Purba Telaumbanua, David Charles Veronika Bertua Simanjuntak