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Mahyarudin, Mahyarudin
Departemen Mikrobiologi, Fakultas Kedokteran Universitas Tanjungpura, Kalimantan Barat, Indonesia
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Journal : Molecular and Cellular Biomedical Sciences (MCBS)

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Chlorogenic Acid Protects Cell Death in the Cerebellum through Anti-Apoptotic Protein Bcl2 in Transient Global Ischemia Cases Hermawati, Ery; Handini, Mitra; Ilmiawan, Muhammad In'am; Mahyarudin, Mahyarudin
Molecular and Cellular Biomedical Sciences Vol 8, No 1 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i1.411

Abstract

Background: Cerebellum is one of the vital components of the brain that will be affected by ischemia-reperfusion (IR) injury. IR injury will increase free radicals, which in turn can trigger apoptosis and cell death. Therefore, this study was conducted to examine the effect of chlorogenic acid administration on apoptosis and the number of cells in the cerebellum of rats with global ischemic transients.Materials and methods: Wistar rats were divided into five groups: sham-operated (C1), IR (C2), IR + 15 mg/kgBW chlorogenic acid (T1), IR + 30 mg/kgBW chlorogenic acid (T2), and IR + 60 mg/kgBW chlorogenic acid (T3). C2, T1, T2, and T3 groups received bilateral common carotid occlusion (BCCO) surgery to induce IR injury. Thirty minutes after BCCO surgery, T1, T2, and T3 rats were administered chlorogenic acid in various doses intraperitoneally. RNA extraction and real-time polymerase chain reaction (PCR) measurements were then performed on NeuN, Bcl2, Bax, caspase 3, as well as on GAPDH as housekeeping genes.Results: There were significant differences in NeuN expressions between groups, with the highest expression shown in C1 followed by T3. Bcl2 expressions were also significantly different between groups, and rats in C1 and T3 showed to be significantly higher compared to C2, while T1 was significantly lower than C1. However, Bax and caspase 3 expressions showed no significant differences.Conclusion: Chlorogenic acid in 60 mg/kgBW dose increases NeuN expression and Bcl2 mRNA expression after transient global ischemia. These increases might correlate with the heightened level of protection against apoptosis in the cerebellum, hence showing its potential in protecting neuron cells.Keywords: transient global ischemia, chlorogenic acid, cerebellum, apoptosis
Co-Authors Abror Irsan Agustina, Risa Alex Alex Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Analekta Tiara Perdana Andriani Andriani Andriani Andriani Andriani Anggie, Joycely Anggita Serli Verdian Anja Asmarany Anzas Niam Saputra Arif Wicaksono Asseggaf, Syarifah Nurul Yanti Rizki Syahab Bimo Hendrayana Delima Fajar Liana Diana Natalia Diana Natalia Diana Natalia Diana Natalia Diana Natalia Effiana Effiana Eka Ardiani Putri Elliska Murni Harfinda Elvin Felix Pratama Ery Hermawati Fajar Liana, Delima Handini, Mitra Hariyanto IH Helmi Sastriawan Herwandi Herwandi Hutahaean, Olifer Jannes Ilmiawan, Muhammad In'am Iman Rusmana Irvandy, Muhammad Syifa Kahtan, Muhammad Ibnu Kurniawan, Prayoga Ledi RN Sulistyawati Liana, Delima F. Liauw, Josephine Johan Mardhia , Mardhia Mardhia Mardhia Mardhia, Mardhia Marizca Okta Syafani Maulana, Muhammad Ali Meika Meidina Yuanita Minami, Gabriella Stephanie Mistika Zakiah Mita Mita, Mita Mitra Handini Muhammad Asril Muhammad In’am Ilmiawan Najini, Robby Nera Umilia Purwanti, Nera Umilia Nizarrahmadi Nizarrahmadi Nur Al Huda Patrio Victorianus Baraga Prasetyo, Raditia Tri Putri, Lidya Hafidzah Qurrota Ayun Rahmawati, Nadia Restika, Risma A. Reza Wahyudi Rialita, Ambar Rifdah, Dzuria Adhana Riki Vernando Rini Andriani Rista Delyani Safira Sukma Dewinda Saputra, Andhika Fadhil Saskya Maulidya Astari Sembodho Edi Kurniawan Shafira Kurnia Warianti Shintya Dewi Sigit Normagiat Sukma Ayu Anandhita Syarifah Nurul Yanti Rizki Syahab Assegaf Syarifah NYRS Asseggaf Tafwidhah, Yuyun Tanti Melinda Tomi Lim Uswatun Hasanah Vanesa, Vanesa Veren Evelyn Chandra Vica Vionita Rosalim Virhan Novianry Vivi Yanthi Warianti, Shafira Kurnia Willy Handoko Willy Sanjaya Yoga Pramana YULIN LESTARI Zaitin Nur Zulfikar Dwi Kiswahyu Nindo