Diabetes mellitus type 2 is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin action, or both. Medication adherence is a crucial factor in achieving optimal glycemic control and preventing complications. This study aims to analyze various factors associated with medication adherence among type 2 diabetes mellitus patients at Peninjauan Health Center, Ogan Komering Ulu Regency, in 2025. A cross-sectional analytical study was conducted involving 73 patients selected through quota sampling. Data were collected via interviews using structured questionnaires, including the Medication Adherence Rating Scale-10 (MARS-10), Hensarling Diabetes Family Support Scale (HDFSS), and Diabetes Obstacles Questionnaire (DOQ). The variables studied included age, gender, education level, employment status, income, disease duration, family support, and healthcare provider support. Data analysis was performed using chi-square tests and multivariate logistic regression. The results showed that 53.4% of respondents were adherent to medication. Bivariate analysis indicated significant associations between medication adherence and age (p=0.041), education level (p=0.042), employment status (p=0.034), disease duration (p=0.026), family support (p=0.003), and healthcare provider support (p=0.002). Multivariate analysis identified healthcare provider support as the dominant factor influencing medication adherence (p=0.001; OR=5.289; 95% CI: 1.929–14.503). These findings conclude that healthcare provider support plays a critical role in improving medication adherence among type 2 diabetes mellitus patients. It is recommended that healthcare providers enhance their support and communication strategies to promote optimal adherence behavior