<![CDATA[Introduction: The most commonly used hypertension medications are calcium channel blockers (CCB). Their oral impact is well recognized for gingival enlargement, yet is very limited to another oral manifestations. Here, we reported a rare case of recurrent aphthous ulcer in a patient under CCB medication.Case Report: A 59-year-old male patient came to Hasanuddin University Dental Hospital with a chief complaint of recalcitrant ulcers on his mouth three weeks ago, which started to occur continuously for a year after the regular consumption of amlodipine. Intraoral examination demonstrated painful solitary white ulcer on the right ventral of the tongue and on the left buccal mucosa. The working diagnosis of recurrent aphthous ulcer et causa CCB was made. Management includes dexamethasone gargle, triamcinolone acetonide gel, and chlorhexidine gluconate, which improved significantly. The patient was suggested to do a consultation with his internist regarding drug substitution.Discussion: The incidence of oral ulcers induced by CCB is predicted to be related to immunological mechanisms. Any drug component triggers an exaggerated immune reaction directed at the surface of the epithelium, resulting in ulcer. The potential for such response depends on the drug's immunogenicity, exposure frequency, and administration route.Conclusion: Practitioners should consider the possibility of oral ulceration triggered by a specific drug, especially if any therapy does not exhibit improvement. Moreover, dental literature must explore the association between CCB and oral ulcers more since this issue has limited explanations.]]>
