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All Journal Dental Journal (Majalah Kedokteran Gigi)
Sari, Tiara Intan Permata
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Dentistry

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Journal : Dental Journal (Majalah Kedokteran Gigi)

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Toxicity test of Stenochlaena palustris extract based on kidney histopathology examination Apriasari, Maharani Laillyza; Sari, Tiara Intan Permata; Firdaus, I Wayan Arya Krishnawan
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p178-183

Abstract

Background: Kalimantan's people consume Stenochlaena palustris leaf extract as food and for traditional medicine. The bioactive components of Stenochlaena palustris leaf extract are flavonoids, alkaloids, saponins, and tannins. An in vitro study shows that the leaf extract has no toxic effect, so it can be used as an alternative drug in oral health, such as in mouthwashes or topical ulcer drugs. Purpose: This study aims to analyze the toxic effects of Stenochlaena palustris leaf extract based on the bleeding and lesions resulting from necrosis in kidney by using histopathology examination. Methods: The Stenochlaena palustris leaves were extracted using 95% ethanol and then given to male Wistar strain (Rattus norvegicus) with a 2,000, 2,500, and 3,000 mg/kg/body weight two times a day for fourteen days. The kidneys were collected and subjected to histopathology examination. Results: There are higher bleeding and necrosis lesion rates in the 2,500 and 3,000 mg/kg/body weight of Stenochlaena palustris leaves extract group compared to the control and 2,000 mg/kg/body weight of Stenochlaena palustris leaves extract group (p<0.05). Conclusion: Stenochlaena palustris leaf extract showed no toxic effect at doses of 2,000 mg/kg/body weight.
Co-Authors Firdaus, I Wayan Arya Krishnawan Maharani Laillyza Apriasari