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Journal of General Procedural Dermatology and Venereology Indonesia

jdvi
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Published by Universitas Indonesia

ISSN : 24607991 EISSN : 24607991 DOI : 10.191

Core Subject : Health,

Medicine & Pharmacology

The initiation of JDVI (Journal of General - Procedural Dermatology & Venereology Indonesia) was done by leading dermatologists and venereologists from Indonesia who aspired to contribute in the field of scientific publication and research. Knowledge and science continue to evolve in the field of dermatology and venereology, especially with new diagnostic methods, therapeutic and procedural approaches, and new emerging diseases.

Arjuna Subject : -

Articles 106 Documents

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Recurrent perianal wart therapy with 90% trichloroacetate (TCA) solution in AIDS patients Sri Linuwih Menaldi; Ika Anggraini; Hanny Nilasari
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 3, No 2 (2019): June 2019
Publisher : Universitas Indonesia

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Background: Being the most commonly found sexually-transmitted infection (STI), anogenital warts are mainly caused by human papilloma virus (HPV) type 6 and 11. These infections are often recurrent, leading to loss of time and medical expenses. Various therapeutic modalities can be chosen singularly or in combination with varying results. Treatments with less responsive results usually occur when acquired comorbidities are present, such as HIV infection. Case Illustration: A 28-year-old homosexual male was reported to have a recurrent perianal wart for the duration of eight months. He was also diagnosed with AIDS and pulmonary tuberculosis. Initially, patient was treated with 25% podophyllin tincture, but there was no improvement. Patient was known to still practicing high-risk sexual behavior. After six treatments of TCA, the warts shrank gradually and no new warts had grown. Discussion: It was found that there is a strong relationship between high incidences of genital warts with reduced immune function due to by HIV infection. Patients infected with HIV will often experience recurrence and needs longer treatment. In this case ARV treatment is given and followed by increase in CD4 count, thereby increasing the effectiveness of the treatment of perianal warts. Conclusion: As recommended by clinical guideline in Indonesia, 90% TCA is proven to be effective in treating recurrent anogenital warts in this case. It is important to counsel the patient regarding the sexual behavior for him and his sexual partner, as it will affect the patient’s prognosis significantly. Keywords: perianal warts, sexually-transmitted infection (STI), TCA solution, immunocompromised

Ulcus vulvae acutum - A rare case Irene Dorthy Santoso; Ika Anggraini; Wresti Indriatmi; Yudo Irawan; Hanny Nilasari; Melani Marissa; Sondang Pandjaitan Sirait; Rahadi Rihamadja
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 3, No 2 (2019): June 2019
Publisher : Universitas Indonesia

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Background: Ulcus vulvae acutum, also known as Lipschütz ulcer, is a rare condition characterized by multiple, painful, and acute genital ulceration in young women without venereal infections, associated with systemic symptoms like malaise, fever, and inguinal lymphadenopathy. Case Illustration: A 24-year-old woman developed multiple and painful vulvar ulcers that recurred for almost a year. The patient was primarily diagnosed and treated as genital herpes in several hospitals with only slight improvement and no complete healing. The patient came to our hospital for examinations to rule out sexually-transmitted infection (STI) (genital herpes, syphilis, HIV, and chancroid) and possibility of Behçet’s. The patient was treated with a combination of 2.5% lidocaine and 2.5% prilocaine creams for 1 week, 2% fusidic acid ointment for 1 week, with no significant progression. Later, the therapy was changed to 0.05% clobetasol propionate ointment for 10 days. Complete healing occurred in about 10 weeks with no scarring. Discussion: Diagnosis of ulcus vulvae acutum in this patient was made by excluding other differential diagnoses. Conclusion: Ulcus vulvae acutum is a difficult diagnosis, and clinician should be aware of this entity especially when encountering young woman without previous sexual experience problem with ulcer. Keywords: ulcus vulvae acutum, genital ulcer, young women

Efficacy of inosine pranobex as an adjuvant oral therapy in anogenital warts: an evidence-based case report Benny Nelson; Indina Sastrini; Lidwina Anissa; Patricsia Manalu; Peppy Fourina; Rahmaniar Desianti Kuraga; Wresti Indriatmi
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 3, No 2 (2019): June 2019
Publisher : Universitas Indonesia

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Background: Human papillomavirus (HPV) causes the most prevalent sexually transmitted infection and is an important etiological factor in genital cancer. HPV infection manifests in broad spectrum, from genital warts to cervical intraepithelial neoplasia and cancers. Genital warts remain a frequent problem in primary care. Current modalities provide unsatisfactory result in curing genital warts completely. To date, there are many convincing studies encouraging oral inosine pranobex as an adjuvant therapy to improve post-conventional therapy cure-rate. Aim: To assess the efficacy of inosine pranobex as an adjuvant oral therapy in anogenital warts. Methods: Literature search was performed using Pubmed, Ebsco and Science Direct database. Inclusion criteria were human subjects, randomized controlled trial on patients with genital warts, and inosine pranobex as adjuvant therapy. The studies were appraised and findings were formulated to find the best evidence for collating recommendations in treating genital warts patients. Results: There were three articles related to the clinical questions. All articles were found to be valid after selection based on exclusion and inclusion criteria. Discussion: All articles recommended the addition of oral inosine pranobex as an adjuvant therapy in treating patient with genital warts. Based on the critical appraisal performed previously, addition of oral inosine pranobex may minimize conventional therapy failure. Conclusion: Based on the best evidence available, we would recommend the addition of oral inosine pranobex as adjuvant for treating genital warts, except in special conditions, such as for patients with financial problem as this therapy was not covered by national health insurance. Keywords: effectiveness, genital warts, inosine pranobex

Clinical diagnostic matrix (CDM) as a tool to diagnose subtypes of epidermolysis bullosa cases in children Suci Widhiati; Benazier Marcella; Susanti Rosmala Dewi; Anggana Rafika Paramitasari; Endra Yustin Ellistasari; Indah Julianto
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 3, No 2 (2019): June 2019
Publisher : Universitas Indonesia

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Background: Epidermolysis bullosa (EB) is a rare genetic skin disease characterized by trauma-induced blisters, which appear shortly after birth. Immunofluorescence antigen mapping and mutational analysis are essential for establishing an accurate diagnosis of EB. However, in limited resource settings like in Indonesia, such techniques are not always readily available, forcing many clinicians to diagnose EB based on clinical features alone that is often inaccurate. Recently, a novel clinical diagnostic matrix (CDM) tool has been developed to improve the diagnostic accuracy of EB in such settings. Case Illustration: We examined clinical photographs and medical records of patients registered at the Dr. Moewardi hospital with a provisional diagnosis of EB since 2013 to 2017 and completed the 19 clinical manifestations required for the CDM’s electronic version. Discussion: CDM provides a diagnosis of the EB subtypes, which cannot be concluded in advance from the previous three cases, although histopathological examination have been carried out. Since immunofluorescence examination and genetic mapping are inaccessible in Indonesia, the CDM gave a brief possibility of diagnosing EB subtypes. Completing the CDM took less than five minutes and the result was available immediately after clinical features data input. Conclusion: CDM appears to be practical, easy to be used and helpful in characterizing EB, especially in limited resource settings. Moreover, it helps in clear documentation of clinical features in an EB patient that could be useful for accurate phenotype-genotype correlations in the future. Keywords: clinical diagnostic matrix, epidermolysis bullosa

Efficacy and safety of 5% imiquimod cream compared to 10% KOH solution for elimination of molluscum contagiosum lesions in adults Marsha Bianti; Agung Muhammad Rheza; Aninda Marina; Rizka Farah Hilma; Sarah Mahri; Rahadi Rihatmadja; Teffy Nuari
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 3, No 2 (2019): June 2019
Publisher : Universitas Indonesia

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Background: Molluscum contagiosum (MC) is a benign infection caused by the Molluscipox virus that most often affects children and sexually active adolescents. Various topical therapeutic options are available, however, no single intervention is convincingly effective. Potassium hydroxide (KOH) solution is widely used but its usefulness is hampered with adverse effects. Newer preparation, 5% imiquimod cream seems to be as, if not more, effective. However, it is not legally available yet in Indonesia. Aim: To assess the efficacy and safety of 5% imiquimod cream in treating adult molluscum contagiosum. Methods: Literature search was done through Pubmed, EBSCO, dan Cochrane databases. Inclusion criteria included articles in English, available in free full text and matched with the clinical question as well as providing the clinical outcome of papules clearance within 12 weeks. Results: There were three articles found to be related to the clinical question and they were critically appraised for their validity, importance, and applicability. Conclusion: Only two studies were valid and further assessed for their importance and applicability. In regards to importance, imiquimod has fewer side effects than KOH, yet it was not constantly shown to be superior to KOH in curing MC lesions. We conclude that KOH solution is the preferred treatment of MC in adults. Keywords: imiquimod, KOH, molluscum contagiosum, safety, efficacy

Subcutaneous mycosis at the Department of Dermatology and Venereology dr. Cipto Mangunkusumo National Hospital, Jakarta, 1989-2013 Sammy Yahya; Sandra Widaty; Eliza Miranda; Kusmarinah Bramono; Artini Wijayanti Islami
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 1, No 2 (2016): June
Publisher : Universitas Indonesia

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Introduction: Subcutaneous mycosis (SM) is a fungal infection involving dermis and subcutaneous tissue, which can disseminate slowly through systemic blood or lymphatic circulation. The subacute or chronic infection usually found in workers of rural tropical and subtropical area. SM occurs due to trauma along with other predisposing factors such as sex, genetic and occupation. Aim: To identify the types of SM, its clinical findings, laboratory work-up and the treatment at the Dermatomycology Division, Department of Dermatology and Venereology dr. Cipto Mangunkusumo National Hospital between the year 1989 and 2013. Method: This retrospective study collected data from medical records and case reports of patients with SM who came at Department of Dermatology and Venereology dr. Cipto Mangunkusumo National Hospital (1989-2013). Results: We found 16 cases of SM, i.e. subcutaneous mucormycosis (5 cases), eumycetoma (4 cases), actinomycetoma (4 cases) and chromoblastomycosis (3 cases). There was a greater number of male than female patients ratio (3:1) and mostly were in the age group of 25-44 years. The direct microscopic examination did not reveal any fungal element, except for black spora in chromoblastomycosis (1 case). The culture revealed Basidiobolus ranarum in subcutaneous mucormycosis (5 cases), Nocardia transvalensis in actinomycetoma (1 case) and Phialophora sp. in 1 case of chromoblastomycosis. On histopathological examination, we found fine granules of actinomycetoma, sulphuric granules of actinomycetoma, coenocytic hyphae of subcutaneous mucormycosis, eosinophilic granule in 1 case of mycetoma and hyphae with black spore in chromoblastomycosis. Conclusion: SM is still a rare disease, comprehensive management of SM needs supporting laboratory work-up, particularly the histopathological examination. Keywords: mycosis, subcutaneous, culture, histological

The effect of injection of ADSC compared to APPE on collagen density in aging skin (animal study) Erlina Pricilla; Indah Julianto; Harijono Kariosentono; Dyah R Budiani; Yuda Heru Fibrianto; Yuyun Rindiastuti; Ainun Veraida
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 2, No 2 (2017): December 2017
Publisher : Universitas Indonesia

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Introduction: Aging is a biological process that can induces changes to the structural integrity and physiological function of skin. Structural changes of skin are a result of dermal atrophy, decreased collagen, the loss of subcutaneous fat, the loss of inherent elasticity, and increased melanogen.1,5,6 From the definition itself, a stem cell characterized by its ability to self-renew and also have an ability to differentiate along multiple lineage pathways.2,4 ADSC which is a kind of mesenchymal stem cell from human adipose tissue, have some potential properties as stem cells derived from bone marrow.4,7 Objective: The aim of this study was to verify the comparison effect of ADSCs and their secretome for skin aging treatment. Methods: ADSC were isolated from lipoaspirates obtained from healthy donors after obtaining written consent and ethical approval using liberase enzymatic digestion, washed with steril PBS and centrifuged. After the phase, ADSC were seeded directly after isolation with liberases and cultured, then produced the conditioning media (AAPE) by hypoxia amplifies.3,4,6,7 We analysed the ADSCs (2,5 x 105 cells) and their secretomes (0,1ml in 0,4ml NaCl 0,9%) by subcutaneous injection on the back of a rat (with range age 48 weeks), and followed began every two weeks after injected until six weeks and stained with Van Giesson staining, for measured the density of collagen.3,5,6 Results: Collagen density was increased after ADSC injected to the skin. From statistical analysis showed there was a significant result of collagen density compared to control group and AAPE (p<0.05). We conclude that ADSC had anti-aging potential or regenerative by stimulating collagen synthesis of dermal fibroblast. ADSC will be as new modality treatment for aging skin in future. Keywords: adipose-derived stem cells, aging skin, secretomes

The effect of face washing frequency on acne vulgaris patients Rini Hastuti; Etty Farida Mustifah; Imroatul Alya; Muhammad Risman; Prasetyadi Mawardi
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 3, No 2 (2019): June 2019
Publisher : Universitas Indonesia

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Background: Patients with acne often wash their faces twice a day, but there are not many studies supporting this practice. Methods: A single-blind randomized clinical trial was conducted in 38 subjects, divided into three groups based on face washing frequency (once, twice, and thrice a day). All groups used the same cleanser. The acne vulgaris severity and the number of lesions were assessed prior to study. After eight weeks, we re-assessed the acne severity, the number of lesions, the adverse event and patient’s self-evaluation. SPSS 17 was used to analyze the face washing frequency and the number of acne lesions.Results: Reduction in the average number of acne lesions was found in once and twice face washing groups, while the thrice group had increased number of acne lesions. The frequency of face washing with the number of lesions provided significant result in group 1, but it only reduced the number of comedones (p value = 0.041).Conclusion: Acne patients with only comedones lesions can be advised to wash their faces once a day. Keywords: acne vulgaris, face washing, frequency

Multiple juvenile xanthogranuloma: A rare case of having clinical appearance mimicking molluscum contagiosum or syringoma Heru Nugraha; Ridha Rosandi; Evelyn Lina Nainggolan; Githa Rahmayunita; Triana Agustin; Rahadi Rihatmadja; Siti Aisah Boediardja
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 1, No 1 (2015): August
Publisher : Universitas Indonesia

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Introduction: Juvenile xanthogranuloma (JXG) is an uncommon benign cutaneous fibrohistiocytic, self-healing, class II non-Langerhan’s cell histiocytosis (NLCH). JXG accounts for 80-90% of cases of NLCH. It occurs most commonly on the head and neck of infants and young children and resolves spontaneously. Case: A one year-old boy presented with asymptomatic, multiple yellowish, shiny, and firm nodules with telangiectasia on the surface, measuring around 1 centimeter in diameter, on the face, the trunk, the arms, and lower extremities. The first lesion appeared on the face 8 months prior to consultation then spread gradually to other areas. He was referred from another hospital and was diagnosed as molluscum contagiosum (MC) with differential diagnosis of syringoma. Enucleation had been performed but failed to produce the molluscum bodies. Initial histopathological examination provided the diagnosis of syringoma. The second histopathological examination showed dermal inflammatory cells consisting of eosinophils, lymphocytes, and histiocytes with marked foam cells and giant cells. Eccrine sweat glands were normal. Some lesions decreased in size at subsequent follow-ups; observation was advised until 3-6 years. Discussion: JXG should be suspected in cases with multiple yellowish nodules appearing in the first year of life. MC usually presents with whitish papules, whereas syringoma is more rarely appeared, presenting with yellow-to-brownish papules. Histopathological examination can easily differentiate the suspected diagnoses; however, selection of lesion, timing and complete clinical information was crucial in reaching the final diagnosis. In this case there was a good clinicopathological correlation that the diagnosis of JXG was made with certainty. There was no eye and other organ abnormalities. Keywords: juvenile xanthogranuloma, clinicopathological correlation

Acquired vulvar lymphangioma: Report of two cases Indah Widyasari; Hafiza Fathan; Larisa Paramitha Wibawa; Herman Cipto; Adhimukti T Sampurna; Sondang P Sirait
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 1, No 2 (2016): June
Publisher : Universitas Indonesia

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Vulvar lymphangioma is a rare case and often being misdiagnosed as genital wart. This acquired disorder manifests as dilatation of superficial lymph vessel due to obstruction. It is caused by urogenital infection and most often occurs following surgery and radiotherapy of cervical cancer. The diagnosis is established based on clinical and histopathological features. Treatment aimed to eliminate the cause of obstruction. This article reports two cases of vulvar lymphangioma found in our Hospital. First case was a 43-year-old female with a history of surgery and radiation for cervical cancer 10 years ago presented with vesicular skin lesion in genital area, oozing copious clear fluid since 4 years ago. There are multiple lenticular vesicles containing clear fluid in vulvar area accompanied with bilateral lymphedema of lower extremities. Histopathological features demonstrated dilated superficial lymph vessels. Second case was a 44-year-old female with enlargement of lower abdomen with vesicular lesion containing clear fluid in genital area since 3 years ago. Abdominal USG showed enlarged inguinal lymph node. Histopathological features demonstrated dilated superficial lymph vessels. The treatment for both cases were gradual electrosurgery. In both cases, vulvar dermis’ superficial lymph node dilatation caused the skin lesions. Obstruction of lymph vessel due to radiation and surgery for cervical cancer in the first case and of inguinal lymph node in the second case lead to increased lymphatic pressure in the dermis and later on the dilatations. The treatment in both cases using electrical excision produced good responses; however, we should be attentive on recurrent case. Keywords: acquired vulvar lymphangioma, dilatation of dermal lymph vessels, electrosurgery

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Home Page

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Editorial Address "Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo General Hospital Diponegoro 71, Central Jakarta 10430"

Location Kota depok, Jawa barat INDONESIA

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Contact Name
-

Contact Email
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Journal Mail Official
jgenprodvi@ui.ac.id

Editorial Address
"Department of Dermatology and Venereology Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo General Hospital Diponegoro 71, Central Jakarta 10430"

Location
Kota depok,

Jawa barat

INDONESIA