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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
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Articles 8 Documents
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Search results for , issue "Vol 20 No 1 (2023): Jurnal Farmasi Indonesia" : 8 Documents clear
Uji Aktivitas Antihipertensi Ekstrak Dan Fraksi-Fraksi Daun Matoa Pada Tikus Jantan yang Diinduksi Angiotensin II dengan Parameter Kadar Renin dan Angiotensin II Iyem Shahira; Jason Merari; Ika Purwidyaningrum
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.926

Abstract

ABSTRACT Matoa leaves (Pometia pinnata) is a plant thought to have hypertensive activity because it contains kuersetin. Research conducted by (Purwidyaningrum, 2017) extracts and fractions of matoa leaves has antihypertensive activity with an effective dose of 150 mg/kg. Other studies conducted by (Elisa, 2019) effects that can reduce blood pressure are extract doses of 300 mg and 30 mg of ethyl acetate fraction induced by angiotensin II can reduce systolic and diastolic blood pressure. This study aims to determine extracts and fractions of matoa leaves in decreasing renin levels and angiotensin II levels. The extraction method was maseration with 96% ethanol solvent and fractionated by liquids method using n-hexane solvent, ethyl acetate water. In this study used 21 male wistar strain rats divided into 7 groups, namely group I (normal), group II as negative control (CMC 1%), group III as positive control (Irbesartan), group IV (matoa leaves extract 60 mg/200g), Group V (fraction n-hexane 2,34 mg/200g), Group VI (ethyl acetate fraction 9,54 mg/200g), Group VII (water fraction 7,98 mg/200g). The results showed ethanol extract and matoa leaves fractions were not significantly difference in meaning with the positive control group different in reducing blood pressure, renin levels and angiotensin II induced by angiotensin II and were significantly from the normal and negative group. The water fraction (7,98 mg/200g) showed a decrease in systolic blood pressure of 9.0% and diastolic 7.1%, the ethyl acetate fraction showed a decrease in renin level 0f 23.6 %. EDM showed a decrease in 17.2% angiotensin II levels. Keyword : Pometia pinnata; renin levels; angiotensin II levels; induced angiotensin II
Analisis Pengendalian Persediaan Obat Kategori Av Dengan Metode Abc, Ven Dan Eoq Di Instalasi Farmasi Rumah Sakit Aura Syifa Kediri Chandra Arifin; Tri Wijayanti; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1086

Abstract

ABSTRACT Inventory Control Analysis Of AVMedicine CategoriesbyABC, VEN and EOQ Method In Pharmacy Installation at Aura Syifa Hospital Kediri.Pharmaceutical logistics management and pharmaceutical services aim to identify, prevent and resolve drug-related problems. Broadness of services and Aura Syifa Hospital Kediri participation in Jaminan Kesehatan Nasional (JKN) requires an efficient pharmaceutical supplies management. Regulations changes in Badan Penyelenggara Jaminan Sosial (BPJS) regarding tiered referral also change the pattern of drug consumption. In addition, arrears of BPJS patient claim payment at Aura Syifa Hospital Kediri during the last few months caused hospital to be slightly constrained in terms of operations and services, especially related to the procurement of medicines. Purpose of this study was to analyze control system and improve the efficiency of managing AV classification medicine using ABC, VEN and EOQ methods inpharmacy installation at Aura Syifa Hospital Kediri.This study wasdescriptive with retrospective data collected, data used in the period January 2018 - December 2018. Medicine analyzed were oral drugs, injections and infusions that were included in group A from the results of ABC analysis, group V from the results of VEN analysis so it was obtained BPJS medicine AV categories. Result of this study were combination of ABC and VEN analysis methods could identify drugs that require strict inventory control and prioritize 12 BPJS medicine in AV category. Pharmacy installation at Aura Syifa Hospital Kediri in 2018 did not meet cost efficiency that is: procurement frequency was higher than the EOQ method. Calculation of ABC, VEN and EOQ methods may improve efficiency in controlling AV classification medicine supplies in BPJS patients at IFRS Aura Syifa Kediri.
Studi Mekanisme Molekuler Antibakteri dari Daun Telang (Clitoria ternatea L.) Mario Hendrik Refwalu; Ana Indrayati; Ika Purwidyaningrum
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1193

Abstract

The bacterium is one of the infectious pathogens that cause infectious diseases. A problem currently developing in the treatment of infectious diseases is antimicrobial resistance. Antimicrobial resistance is the inability of an antibiotic to cure infectious diseases so that new antimicrobial compounds are needed that can kill infectious pathogens (by bacteria, fungi, viruses, and multi-cellular parasites). The butterfly pea plant (Clitoria ternatea L.) has been identified as a potential antibacterial plant. This literature study aims to determine the antibacterial activity and identify molecular mechanisms based on the chemical content of telang leaves that have not been done before. This literature study uses the systematic literature review (SLR) method to determine the activity and antibacterial mechanisms based on the bioactive compounds contained by using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyzes) as the review protocol. Data search strategy using search engines: science direct, google scholar, and Pubmed. The keyword search uses a combination of words in the problem statement and uses the Boolean "OR" and "AND". The finding shows that the relevant literature obtained 22 articles that met the criteria consisting of articles on chemical compounds, antibacterial activities and mechanisms. The SLR results showed that telang leaf has potential as an antibacterial and has a molecular mechanism, namely, interfering with the permeability of cell membranes, inhibiting nucleic acid and protein synthesis and inhibiting the formation of biofilms. Chemical compounds that have the potential as antibacterial agents are kaempferol, quercetin, cyclotide, b-sitosterol alkaloids and tannins.
Formulasi Nanoemulgel Ekstrak Biji Kopi Robusta (Coffea canephora Pierre) Dengan Variasi Gelling Agent Sebagai Antioksidan Raden Roro Karina Pambudi; reni ariastuti; Ahwan Ahwan
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1518

Abstract

Antioxidants are compounds that are significant in the body's mechanism against free radicals, namely inhibiting oxidative reactions by binding to free radicals or preventing oxidative damage that can lead to oxidative stress conditions. One of the natural ingredients that have antioxidant activity is robusta coffee beans. Robusta coffee beans contain polyphenol compounds have antioxidant activity. Nanoemulgel s a gel preparation that is incorporated in a basic gel and has nano-sized particles. This study aims to 1) determine the stable formula of robusta coffee bean extract nanoemulgel with a variation of gelling agent 2) determine whether the robusta coffee bean extract nanoemulgel has antioxidant activity. The methods used include 1) extraction with maceration 2) nanoemulsions are made using a low-performance technique (magnetic stirrer) and a high performance technique (sonicator) 3) particle size test used dynamic light scattering 4) stability parameters include pH, dispersibility, adhesion, and viscosity 5) antioxidant activity was analyzed using the DPPH method (1,1-diphenyl-2- picrylhydrazyl) 6) statistical analysis used SPSS 21 software using Paired T-test and One Way Anova. The results nanoemulsion particle size of robusta coffee bean extract was 12.3 nm and the polydisperse index was 0.274 nm, the most stable nanoemulgel was formula 3 with varying concentrations of gelling agent (1 gram HPMC: 0.5 gram Carbopol) had an average value of pH 5, average adhesion 1.59 seconds ± 0.01, average dispersion 6.7 cm ± 0.1, and the average viscosity value of 2500 cPs. The formula with the strongest antioxidant activity is formula 1 (0.5- gram carbopol) with an average IC50 value of 10.678 ± 0.0346 ppm.
Kombinasi nanoemulsi Minyak Kemiri (Aleurites mollucana L.) dan Serbuk Daun seledri (Apium graveolens L.) pada Model Penyakit Alopesia Yonathan Tri Atmodjo Reubun; Anggelina Aprilia Pangalila
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1856

Abstract

Candlenut oil and celery leaves have been widely used by people in the world as a treatment for hair loss problems as well as strengthening hair roots and blackening hair. Hair loss disease or in the medical world called alopecia is a disease where the amount of hair loss is more than hair growth in general. The main cause pf alopecia generally occurs due to inflammation in the hair follicles. The purpose of this experimental animals used, namely male rabbits of the New Zealand White type. The study began by testing the phytochemical screening on each of the materials used. Furthermore, a combination of candlenut oil and celery powder was carried out to form a nanoemulsion preparation. After that, tests were carried out including pH, emulsion type, hair growth including hair weight and thickness of the shaving area. The results showed that the co,bination of candlenut oil and celery powder had a pH value of 6.30 with an emulsion type, namely oil in water (O/W) and had hair growth activity from test animals for 28 days with the average weight and thickness of hair 0.2458 and 1,15 cm. this result is better than average positive control product X with an average weight and thickness of 0.2076 and 1 cm. in addition, compared with the negative control, the results of weight and hair thickness were 0.0305 and 0.5 cm. based on these results, it was concluded that the combination of candlenut oil and celery powder had good hair growth activity in experimental animals so that it could be used as treatment therapy for alopecia patients.
Peningkatan Aktivitas Antioksidan pada Ekstrak Daun Kelor (Moringa oleifera) melalui Fermentasi: Studi Perbandingan Kandungan Fenolik dan Aktivitas Antioksidan Hery Muhamad Ansory; Nuraini Harmastuti; Windia Wulantika; Afif Meilana Sindani Putri
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1652

Abstract

This study aimed to investigate the effect of fermentation on the antioxidant activity and phenolic content of 96% ethanol extract from Moringa oleifera leaves. While the antioxidant potential of Moringa leaves has been recognized, this research introduces a novel concept of utilizing fermentation to enhance the levels of active compounds. The state of the art in antioxidant activity and fermentation is used to validate the significant improvement in antioxidant activity. The findings provide new insights into utilizing Moringa leaves as a natural antioxidant source obtained through fermentation. The research methodology involved fermenting the 96% ethanol extract from Moringa leaves using Lactobacillus B bacteria for 24, 48, and 72 hours. The phenolic content was measured using the Folin-Ciocalteu method, while the antioxidant activity was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The results demonstrated a significant increase in phenolic content after the fermentation process. The phenolic content of the fermented Moringa leaf extract was 86.133±5.925 mgGAE/gram after 24 hours, increased to 91.244±7.374 mgGAE/gram at 48 hours, and reached 122.578±9.576 mgGAE/gram at 72 hours. Additionally, the antioxidant activity also increased with fermentation time. The IC50 values for samples fermented for 24, 48, and 72 hours were 60.887 µg/ml, 58.742 µg/ml, and 53.169 µg/ml, respectively. These results indicate that fermentation of Moringa leaf extract can significantly enhance phenolic content and antioxidant activity.
a Kajian Naratif Pengukuran Kualitas Peresepan Pasien Diabetes Mellitus Lanjut Usia Fisia Niti Admadja; Yosi Irawati Wibowo; Karina Kumaladewi Widjaja; Adji Prayitno Setiadi
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1468

Abstract

The aging populations has increased worldwide, resulting in higher prevalences of non-communicable diseases, including Diabetes Mellitus (DM). Elderly with DM requires long-term prescribing which warrants special considerations. Hence, this narrative review aims to identify quality measurement tools and quality prescribing in elderly patients with DM. This review included literature searching in three databases [i.e., Pubmed (MEDLINE), Science Direct, and CINAHL] with combination of keywords: (Diabetes) AND (Elderly OR older OR geriatric) AND (“Potentially inappropriate medication” OR “potentially inappropriate prescribing” OR “inappropriate prescribing” OR “quality prescription” OR “rational prescribing”). The searching resulted in 1059 articles; and after the selection process, 10 articles were included in this study. The extracted data indicated that tools with explicit criteria (such as Beer's Criteria) were more commonly used to measure quality prescribing in elderly patients with DM compared to those with implicit criteria (i.e., Prescribing Quality Assessment Checklist) (9 articles versus 1 article, respectively). Varying quality prescribing were reported dependent on the tools used. The percentage of Potentially Inappropriate Medication (PIM) measured using explicit tools ranged from 22,7% to 68,1%; glibenclamide or glyburide were among the most common PIM. Whereas, 83.2% of precriptions measured with the implicit criteria in one article indicated poor quality. This finding demonstrated the needs of strategy to improve the quality of prescribing in elderly patients with DM.
Elimination of the Ultraviolet Spectrophotometric-Based Limitation on the Quantification of Metformin HCl in Acid-Stage Medium for a Comparative Dissolution Testing Syaiful Choiri; Dwi Larasati; Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.2150

Abstract

Herein, this work aimed to develop an ultraviolet spectrophotometric assay for metformin HCl in comparative dissolution testing along with the acid stage medium due to low molar absorptivity. Metformin HCl was incorporated into the immediate tablet formulation to mimic the analytical matrix system. The dissolution validation procedure was carried out by linearity, accuracy, precision, the limit of quantification, filter compatibility, and aliquot stability that fulfil the USP method for validation of dissolution procedure, particularly assay of the analyte.The results revealed that metformin HCl had difficulty quantifying in acid pH due to the absence UV-band peak. The addition of pH-shifting agents promoted better performance for metformin quantification. Therefore, the method was successfully developed along with R2, predicted R2, accuracy, and precision of 0.9999, 0,9998, 100.57%, and 1.27%, respectively. In addition, it had the minimum placebo interference (0.47%) and was stable for long-term storage under determined conditions.

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