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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 6 Documents
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Search results for , issue "Vol 7 No 2 (2010): Jurnal Farmasi Indonesia" : 6 Documents clear
Uji Aktivitas Antibakteri Ekstrak Etanolik Daun Sisik Naga (Drymoglossum piloselloides (L) Presl) terhadap Shigella dysenteriae ATCC 9361 dengan Metode Soxhletasi dan Perkolasi Tinuk Wuryandari; Bambang Iskamto; Ismi Rahmawati
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (752.603 KB) | DOI: 10.31001/jfi.v7i2.23

Abstract

Leaves of Drymoglossum piloselloides [L.] Presl. were used as dysentery drug. The experiment was aimed to find out whether soxhletation and percolation extracts of Drymoglossum piloselloides [L.] Presl. leaves had antibacterial activity against Shigella dysenteriae ATCC 9361. Lleaves were dried and then blended to make powder. The extraction method used was soxhletation and percolation methods using ethanol 70% solvent. The obtained extract was evaporated until it was thick, and then the antibacterial activity test was conducted by dilution method against Shigella dysenteriae ATCC 9361. he concentrations of the test solutions were: 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%, 0.39%, 0.19%. The result of the experiment showed that soxhletation and percolation extracts had antibacterial activity against Shigella dysenteriae ATCC 9361 test bacteria. There was no difference in antibacterial activity between soxhletation extract and percolation extract against Shigella dysenteriae ATCC 9361 showed by minimum bactericidal concentration i.e. 50% both.
Pengaruh Cairan Penyari terhadap Rendemen dan Kadar Tanin Ekstrak Daun Jambu Biji (Psidium guajava L.) Arum Triyas Wardani; Fransiska Leviana
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.948 KB) | DOI: 10.31001/jfi.v7i2.24

Abstract

The leaves of guava (Psidium guajava L.) has been used and produced by industrial as an antidiarrheal. Active substances that act as an antidiarrheal in the leaves of guava are the tannins. Tannins are phenolic compounds that are soluble in water, ethanol or water-ethanol mixture. This study aims to determine the influence of solvent on yield and tannins content in the guava leaf extract and to determine the most optimal solvent for the manufacture of guava leaf extract with the maximum tannins content. The research was conducted by extracting the leaves of guava by maceration with ethanol 50%, 70%, 90%. Viscous extract obtained is then analyzed yield and tannins content. Quantitative analysis of tannins performed by permanganometry titration method. In this research shows that qualitatively the ethanol extract of guava leaves contain tannins. The results showed that solvent affect the yield and tannins content in the guava leaves extract. The yield of extract for 50%, 70%, 90% ethanolic extracts were 22,07%; 31,87%; 25,13%. Tannins content in the 50%, 70%, 90% ethanolic extract were 23,37%; 14,28%; 10,96%. The most optimal solvent for the manufacture of guava leaf extract with the highest tannin content was ethanol 50%.
Uji Mutu Fisik Tablet Ekstrak Daun Jambu Monyet (Anacardium occidentale L.) dengan Bahan Pengikat PVP (Polivinilpirolidon) secara Granulasi Basah Dyah Susilowati; Yogi Adi Christanto
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2868.042 KB) | DOI: 10.31001/jfi.v7i2.25

Abstract

Leaves of Anacardium occidentale L. as a diabetes mellitus drug will be made tablets. test the physical quality of tablets of Anacardium occidentale L leaves extract made by wet granulation with a binder PVP (polyvinylpyrrolidone). The extract of leaves of Anacardium occidentale L was obtained by maceration. The leaves of Anacardium occidentale L extract tablets were produced by wet granulation method. The granules are then tested for physical properties include flow time, angle of repose, drying shrinkage and moisture content. Tablets are tested for physical properties including hardness test, friability test, weight uniformity test and disintegration time. The results of this study are based on existing literature and statistical analysis to test the physical quality of the tablet. The granules obtained had a drying shrinkage of 1,16%, flow time of 5,81 seconds, and angle of repose of 24,11 0. The results of this study is the average uniformity of tablet weight is 0.642 grams. The average tablet hardness was 7.61 kg. The average number of fragility tablet is 0.13%. Average duration of crushed tablets is 5 minutes 22 seconds.
Pengaruh Bahan Pengikat Gelatin dalam Formula Tablet Ekstrak Daun Kemuning (Murraya paniculata (L.) Jack) secara Granulasi Basah Yeni Fitriana; Titik Sunarni; Widodo Priyanto
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (705.053 KB) | DOI: 10.31001/jfi.v7i2.26

Abstract

Kemuning (Murraya paniculata (L.) Jack) is one of Indonesia medicine plants. Kemuning leaves can be used to decrease cholesterol. The experiment was aimed to make tablets of kemuning leaves extract with gelatin as binding agent that fulfilled the requirements of tablet’s physical quality. Extract of kemuning leaves was obtained from kemuning leaves powder by maceration method using ethanol 70%. The obtained extract was soaked for several days and then evaporated till thick extract was obtained. Kemuning leaves extract tablets were made in 3 formulation with difference concentrations of binding agent, i.e. formula I contained 1% of gelatin mucilage 5%, formula II contained 2% and formula III contained 3%. The method used to make tablets of kemuning leaves extract was wet granulation method. The obtained granules were physically tested in cluding flowing time, the angle of repose, and loss on drying. The obtained tablets were physically tested including weight homogeneity, hardness, friability and disintegration time. The obtained data was statistically analyzed using SPSS 11.0 for windows program i.e. one way anova added with one factor at 95% convidence. The conclusion of the experiment was that kemuning leaves extract could be made tablets that fulfilled therequirement of tablet’s physical quality. The result of the experiment showed that the three formulations produced tablets with weight homogeneity, hardness, friability and disintegration time that fulfilled the requirement of good physical quality of tablet.
Aktivitas Antibakteri dan Penyembuhan Luka Fraksi-Fraksi Ekstrak Etanol Daun Kamboja (Plumeria acuminata Ait) pada Kulit Kelinci yang Diinfeksi Staphylococcus aureus Gunawan Pamudji Widodo; Dwi Ningsih; Dan Mona Aprilia
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (836.634 KB) | DOI: 10.31001/jfi.v7i2.27

Abstract

Kamboja (Plumeria acuminata Ait.) plant is traditional medicine used as medication for abscess and yaws. Flavonoid is a component of chemical compound in kamboja leaves that supposed to have antibacterial activity. The aim of the experiment was to find out the ability of kamboja leaves fractions creams in healing the infection of Staphylococcus aureus on rabbit skin and to know the most effective concentration. Kamboja leaves were extracted by soxhletation method using 96% ethanol solvent, and then the obtained extract was fractionated using n-hexane, ethyl acetate and 70% ethanol solvents. The antibacterial activities of the three fractions were tested in the form of creams by in vivo method. It was found that ethyl acetate fraction was the most effective, and then various doses were conducted with concentrations of 15%, 20%, and 25% using test animals infected by Staphylococcus aureus.The result of the experiment showed that ethyl acetate fraction had the best ability compared with n-hexane and ethanol 70% fractions. Ethyl acetate fraction cream concentration of 15%, 20%, and 25% could heal the infection for 11.40, 10.60 and 9.40 days, respectivelly.
Aktivitas Antioksidan Herba Kate Mas (Euphorbia heterophylla L.) terhadap Radikal DPPH (1,1-Difenil-2-Pikrilhidrazil) Louis Madalena; Titik Sunarni; Fransiska Leviana
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (837.089 KB) | DOI: 10.31001/jfi.v7i2.28

Abstract

Antioxidant is very important to keep human’s health because of it can scavenge free radical. Flavonoid is usual natural antioxidant got on plants. Euphorbia heterophylla L. which is used by people as traditional herbal medicine and it has traditional name kate mas is known contain of flavonoid, tannin and saponin. The aim of the experiment was to find out the antioxidant activity of kate mas (Euphorbia heterophylla L.) herb and the potency of methanolic extract, hexane, etil acetat and water fractions, and also of kate mas herb on DPPH (2,2-difenil-1-pikrilhidrazil) radical with IC50 parameter. Kate mas herb were extracted by maceration method using methanol. The obtained extract was partitioned with water and hexane, and then with etil acetat. The antioxidant activity of the obtained fraction was tested against DPPH radical. The test was conducted in 4 series of concentrations by adding 4.0 ml test solutions with 1.0 ml DPPH 0.45 mM. The radicals scavenging activity was measured with spectrophotometer at 515 nm wavelength and determined the IC50 value. The experiment used rutin as positive control. The result of the experiment showed that kate mas herb had antioxidant activity with IC50 of methanolic extract, water fraction, n-hexane fraction, and etil acetat fraction: 44,43 ppm; 130,63 ppm; 212,81 ppm; and 5,88 ppm respectively. The etil acetat fraction has the strongest activity compairing to the other with the IC50 is almost near often rutin’s IC50 is 5,11 ppm as the positif control.

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