Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

ISM (Intisari Sains Medis) : Jurnal Kedokteran

ism
Website

Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

Arjuna Subject : -

Articles 57 Documents

1 2 3 4 5

Search results for , issue "Vol. 13 No. 2 (2022): (In Press : 1 August 2022)" : 57 Documents clear

Efektifitas daun salam dalam mengurangi cemaran mikroba penyebab busuk telur itik Yulidia Iriani; Yan Ramona; Ni Putu Adriani Astiti
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Pathogenic bacteria on eggshells or egg contents will be very dangerous for the health of humans who consume them. Chemicals should not be an option for preservatives because they will cause side effects. In this study, we explored the possibility of using bay leaf extract (Syzygium polyanthum (Wight) Walp) to control the growth of polluting bacteria in salted duck eggs so that the shelf life can be extended. The purpose of the study was to determine the potential of the active compounds contained in bay leaves in reducing the total plate count/microbial contamination in salted duck eggs. Methods: Extraction of bay leaf powder was carried out by the infusion method. The activity test of bay leaf decoction (ARDS) was carried out using the in vitro diffusion well method on Mueller Hinton media. Identification of active compounds was carried out using the GCMS technique. Results: ARDS crude extract at a concentration of 5% (v/v) could significantly reduce ALT and inhibit the in vitro growth of Proteus mirabilis bacteria at a concentration of 10% (w/v), with an inhibition zone diameter of 19.53 mm, with the minimum value inhibitory concentration (MIC) 0.7%. The results of the GCMS analysis of ARDS showed that the ten peaks produced, possibly synergized, and had antimicrobial activity. These compounds are 2-Pentanone4-Hydroxy-4 Methyl (CAS) Diacetone Alcohol; Ethanol, 2-(Ethoxythoxy) (CAS); 1,2,3 Propanetrriol Cas) Glycerol; Citronella (2,6-Octadien-1-Ol, 3,7-Dimethyl, (CAS); Beta Citronellol 6-Octen-1-Ol, 3,7 Dimethyl-(CAS); Trans Geraniol; Dodecanoic Acid, Methyl Ester (CAS) Methyl Laurate; Tetradecanoic Acid, Methyl Ester (CAS) Methyl Myristate; 1-Tetradecanol (Cas) Alfol 14 and Hexadecanoic Acid Methyl Ester CAS) Methyl Palmitate Conclusion: Leaf decoction can inhibit the growth of Proteus mirabilis in vitro, and the addition of ARDS with a concentration of 5% (v/v) can significantly reduce the value of bacterial contamination in salted duck eggs. Latar Belakang: Bakteri pathogen pada kulit telur atau isi telur akan sangat membahayakan kesehatan manusia yang mengkonsumsinya. Bahan kimia seharusnya tidak menjadi pilihan untuk pengawet, karena akan menimbulkan efek samping, Pada penelitian ini dieksplorasi, kemungkinan dipakainya ekstrak daun salam (Syzygium polyanthum (Wight) Walp) untuk mengontrol pertumbuhan bakteri pencemar pada telur itik yang diasinkan, sehingga masa simpannya dapat diperpanjang. Tujuan penelitian untuk mengetahui potensi senyawa aktif yang terdapat pada daun salam dalam menurunkan angka lempeng total/cemaran mikroba pada telur itik yang diasinkan. Metode: Ekstraksi serbuk daun salam dilakukan dengan metode infusa. Uji aktifitas air rebusan daun salam (ARDS) dilakukan dengan metode sumur difusi secara in vitro pada media Mueller Hinton. Identifikasi senyawa aktif dilakukan dengan teknik GCMS. Hasil: Ekstrak kasar ARDS pada konsentrasi 5% (v/v) secara nyata dapat menurunkan ALT dan menghambat pertumbuhan in vitro bakteri Proteus mirabilis pada konsentrasi 10% (b/v), dengan diameter zona hambat sebesar 19,53 mm, nilai minimum inhibitory concentration (MIC) 0,7%. Hasil analisis GCMS terhadap ARDS menunjukan bahwa sepuluh puncak yang dihasilkan, kemungkinan bersinergi dan mempunyai aktifitas sebagai antimikroba. Senyawa-senyawa tersebut adalah 2-Pentanone4-Hydroxi-4 Methyl (CAS) Diacetone Alkohol; Ethanol, 2-(Ethoxythoxy) (CAS); 1,2,3 Propanetrriol Cas) Glycerol; Citronella (2,6-Octadien-1-Ol, 3,7-Dimethyl, (CAS); Beta Citronellol 6-Octen-1-Ol, 3,7 Dimethyl-(CAS); Trans Geraniol; Dodecanoic Acid, Methyl Ester(CAS) Methyl Laurate; Tetradecanoic Acid,Methyl Ester (CAS) Methyl Myristate; 1-Tetradecanol (Cas) Alfol 14 dan Hexadecanoic Acid Methyl Ester CAS) Methyl Palmitate. Simpulan: Air rebusan daun dapat menghambat pertumbuhan Proteus mirablis secara in vitro dan penambahan ARDS dengan konsentrasi 5% (v/v) secara signifikan dapat menurunkan nilai cemaran bakteri (angka lempeng total) pada telur itik yang diasinkan.

Korelasi pemeriksaan darah lengkap dengan derajat keparahan COVID-19 pada pasien lansia di Rumah Sakit Umum Daerah (RSUD) Tabanan tahun 2021 Richard Samsudin; I Gede Agus Sastrawan; I Gede Risnawan Suastika Ardanayasa; I Gusti Putu Suka Aryana
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: COVID-19 infects all patients of all ages including the elderly. Several studies have shown that complete blood counts can be used as a marker of the severity of COVID-19. This study aims to examine complete blood counts with the severity of COVID-19 in elderly patients at the Tabanan Regional General Hospital (RSUD) in 2021. Methods: This research was conducted using an retrospective study method, using 277 samples taken from secondary data (patient medical records) at Tabanan General Hospital. The independent variables of study including haemoglobin, haematocrit, leukocytes, relative lymphocyte levels, relative neutrophil levels, neutrophil lymphocyte ratio (NLR), relative eosinophil levels, relative basophil levels, relative monocyte levels, platelets, and depending variable is the severity of the patient, divided to moderate, severe, critically ill. Data analysis using SPSS version 26 for Windows. Results: Complete blood counts were significantly correlated with Lymphocytes (r2 = 0,069; p < 0,001), Monocyte (r2 = 0,045; p < 0,001), Leukocyte (r2 = 0,037; p = 0,001), NLR (r2 = 0,03; p = 0,004), Eosinophil (r2 = 0,022; p = 0,013), and Haematocrit (r2 = 0,069; p = 0,022). Conclusion: In this study, complete blood count (leukocytes, NLR, haematocrit with a positive value correlation, and lymphocytes, eosinophils, monocytes with a negative value correlations) can be used as predictors to assess the severity of COVID-19 patients. However, neutrophils, basophils, haemoglobin, and platelets were not correlated significantly. Latar Belakang: COVID-19 menginfeksi semua pasien dari segala usia termasuk lansia. Beberapa studi menunjukkan bahwa pemeriksaan darah lengkap dapat dipergunakan sebagai penanda derajat keparahan COVID-19. Penelitian ini bertujuan untuk mengevaluasi pemeriksaan darah lengkap dengan derajat keparahan COVID-19 pada pasien lansia di Rumah Sakit Umum Daerah (RSUD) Tabanan tahun 2021. Metode: Penelitian ini dilakukan dengan metode studi retrospektif menggunakan 277 sampel yang diambil dari data sekunder rekam medis pasien di RSUD Tabanan. Variabel independen penelitian meliputi hemoglobin, hematokrit, leukosit, kadar limfosit relatif, kadar neutrofil relatif, neutrofil limfosit ratio (NLR), kadar eosinofil relatif, kadar basofil relatif, kadar monosit relatif, trombosit, dan dependent derajat keparahan pasien yaitu sedang, berat, kritis. Analisis data memakai SPPS versi 26 untuk Windows. Results: Pemeriksaan darah lengkap menunjukkan hasil yang bermakna pada Limfosit (r2 = 0,069; p < 0,001), Monosit (r2 = 0,045; p < 0,001), Leukosit (r2 = 0,037; p = 0,001), NLR (r2 = 0,03; p = 0,004), Eosinofil (r2 = 0,022; p = 0,013), dan Hematokrit (r2 = 0,069; p = 0,022). Conclusion: Pada penelitian ini pemeriksaan darah lengkap (leukosit, NLR, hematokrit dengan korelasi positif, dan limfosit, eosinofil, monosit dengan korelasi nilai negatif) dapat digunakan sebagai prediktor untuk menilai derajat keparahan pasien COVID-19. Akan tetapi neutrofil, basofil, hemoglobin, dan trombosit tidak berkorelasi secara bermakna.

Colonization of Citrobacter koseri and Streptococcus agalactiae in a case of cellulitis cruris dextra et sinistra Luh Gede Melia Puspita Sari; Ni Nengah Dwi Fatmawati; I Gusti Ayu Agung Praharsini; Marvin Giantoro
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Cellulitis is a skin infection involving the deep dermis and subcutaneous tissue, characterized by localized pain, swelling, tenderness, erythema, and warmth. The most common causes of cellulitis are group A streptococci and Staphylococcus aureus. Streptococcus agalactiae or the so-called group B Streptococcus can also cause cellulitis. This case report aims to evaluate the colonization of Citrobacter koseri and Streptococcus agalactiae in a case of cellulitis cruris dextra et sinistra. Case Presentation: A 53-year-old married woman presented to the outpatient clinic complaining of swelling and redness in her left and right legs since five days ago. At first, there was only a little redness around the calf, but it became wider and pain in that area. On examination, there were multiple erythematous macules, patches, and multiple erosional lesions, warm palpable and tender to palpation, and the diascopy test disappeared with pressure. Based on the wound culture results, isolated Citrobacter koseri and Streptococcus agalactiae bacteria were considered colonization. Both of these bacteria were less virulent. The patient was treated with systemic and topical antibiotics, analgesics, wound care management and elevated lower limbs. Conclusion: The diagnosis of cellulitis is based on history and physical examination. On examination of the wound culture of this case, Citrobacter koseri and Streptococcus agalactiae were found, considered as colonization. The patient showed clinical improvement at each observation after administration of antibiotics and wound care management. The patient's prognosis is dubious ad bonam.

Hyperglycemic hyperosmolar state in children: a case series Leni Lukman; I Made Darma Yuda; I Made Arimbawa
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Hyperglycemic hyperosmolar state (HHS) is a life-threatening rare acute complication of diabetes mellitus (DM). The condition should be distinguished from diabetic ketoacidosis (DKA) as the management differs significantly. HHS is classically associated with type 2 DM, but it has been increasingly reported in type I DM as well. The literature regarding HHS in children is still sparse. The management of HHS in children is extrapolated from the adult study. Cases: The first case was male 5 years old, and the second case was female 15 years old. Both cases were typed 1 DM patient. The first case was newly diagnosed. Both of the patients came with general weakness, mild dehydration, overly high blood sugar, normal blood pH, hypocalcemia, glucosuria and only mild ketonuria. In the second case develop, both patients were rehydrated, given insulin and discharged in 7-10 days without any sequelae. Conclusion: These case series emphasize the importance of recognizing HHS and differ it from DKA. These two cases prove that HHS is increasingly reported in children with clinical symptoms resembling DKA. It is also proven that with early diagnosis and correct management, children with HHS can be discharged home without any sequelae.

Infiltrative multifocal glioblastoma progression in a twelve-year-old boy after COVID-19 infection: a case report Angky Saputra; Zaky Bajamal; Francisca Notopuro; Lucia Dwi Puspitasari
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Glioblastoma is one of the most malignant types of primary central nervous system tumors with a high recurrence rate and dismal prognosis. Multifocal glioblastoma has been shown to have a poorer prognosis than solitary glioblastoma. Cancer patients are at risk of contracting COVID-19. It is hypothesized that COVID-19 may induce glioma tumorigenesis via angiotensin enzyme 2 receptor. We reported a rare pediatric multifocal glioblastoma in a twelve-year-old boy complicated with COVID-19. Case Presentation: The patient was a twelve-year-old boy with a new-onset unprovoked seizure and headache. Magnetic resonance imaging (MRI) showed a heterogeneous solid cystic mass in the left temporal region (2.1x2.1x2.8 cm) with an increased choline/creatinine ratio and choline/n-acetyl acetate aspartate (NAA) ratio suggestive for high-grade glioma. The patient was contracting COVID-19 shortly after the diagnosis of glioblastoma. Two weeks later, patients came with significant neurological deterioration, hemiparesis, headache, and vomiting. MRI showed an infiltrative mass in the temporal and parietal region (5.05x8.03x8.3 cm) with intratumoral hemorrhage, also causing midline shift deviation (11.9 mm). The patient underwent trepanation and total safe resection of the tumor. Histopathological findings showed neoplastic cells with abundant mitotic figures, necrotic foci and pseudopalisading necrosis. These findings confirmed the diagnosis of multifocal glioblastoma. Conclusion: Glioblastoma is a rare disease in the pediatric population with a poor prognosis due to its infiltrative nature and high recurrence rate. The patient had an acute deterioration of the neurological condition and rapid growth of the tumor after he contracted COVID-19, which may or may not be incidental. Further observation of similar cases will be required to determine the association between glioblastoma and COVID-19.

Profil kalus dan klavus di Unit Rawat Jalan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya Periode Januari 2016 - Desember 2020 Iskandar Zulkarnain; Arisia Fadila; M. Yulianto Listiawan; Budi Utomo; Afif Nurul Hidayati; Sawitri; Diah Mira Indramaya
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Introduction: Callus and clavus are skin disorders in the form of hyperkeratotic lesions that are common and can affect the patient's quality of life. Callus and clavus can occur in men or women of all ages. Treatment of callus and clavus has a low cost benefit but has received little attention and until now there is no gold standard of treatment that is considered ideal. Data on callus and clavus characteristics, common treatments, and the final outcome of callus and clavus therapy have not been widely reported so that it has an impact on the standard management of these two lesions. The aim of this study was to evaluate the description of callus and clavus cases in the form of gender, age, location lesions, management, and cure rate 1 month after therapy in the Outpatient Unit (URJ) Skin and Venereology Tumor Division and Skin Surgery (TBK) Regional General Hospital (RSUD) Dr. Soetomo, Surabaya. Methods: A cross-sectional retrospective descriptive study on 25 Electronic Medical Records (EMR) patients with callus and clavus who met the inclusion and exclusion criteria at the Dermatology and Venereology Outpatient Unit, Skin Surgery Tumor Division (TBK) RSUD Dr. Soetomo Surabaya period January 2016 - December 2020. Results: Twenty-five samples were recruited in this study consisting of 13 (52%) male patients and 12 (48%) female patients. Clavus dominated all cases in 20 (80%) cases, while callus was in 5 (20%) cases. The lower extremity was the most common site for lesions in 20 (80%) cases. Excision was the most frequently chosen method in 21 (84%) cases. Clinical recovery after 1 month after therapy was obtained in 20 (80%) cases. Conclusion: Management of callus and clavus in URJ Skin and Venereology, TBK Division, RSUD Dr. Soetomo, Surabaya showed a cure rate of 80% with the most preferred modality being excision. Pendahuluan: Kalus dan klavus adalah kelainan kulit berupa lesi hiperkeratotik yang umum didapatkan dan dapat mempengaruhi kualitas hidup pasien. Kalus dan klavus dapat terjadi pada pria ataupun wanita di segala rentang usia. Tatalaksana kalus dan klavus memiliki cost benefit yang rendah namun kurang mendapat perhatian dan hingga saat ini belum terdapat standar emas tatalaksana yang dianggap ideal. Data karakteristik kalus dan klavus, tatalaksana yang umum dilakukan, dan hasil akhir dari terapi kalus dan klavus belum banyak dilaporkan sehingga berdampak pada standar manajemen kedua lesi tersebut. Tujuan dari penelitian ini adalah mengevaluasi gambaran kasus kalus dan klavus berupa jenis kelamin, usia, lokasi lesi, tatalaksana, dan angka kesembuhan 1 bulan paska terapi di Unit Rawat Jalan (URJ) Kulit dan Kelamin Divisi Tumor dan Bedah Kulit (TBK) Rumah Sakit Umum Daerah (RSUD) Dr. Soetomo, Surabaya. Metode: Penelitian deskriptif retrospektif potong lintang pada 25 Electronic Medical Records (EMR) pasien dengan kalus dan klavus yang memenuhi kriteria inklusi dan eksklusi di Unit Rawat Jalan Kulit dan Kelamin Divisi Tumor Bedah Kulit (TBK) RSUD Dr. Soetomo Surabaya periode Januari 2016 - Desember 2020. Hasil: Dua puluh lima sampel direkrut pada penelitian ini terdiri dari 13 (52%) pasien laki-laki dan 12 (48%) pasien perempuan. Klavus mendominasi keseluruhan kasus yaitu 20 (80%) kasus, sedangkan kalus 5 (20%) kasus. Ekstremitas bawah merupakan lokasi tersering didapatkannya lesi yaitu pada 20 (80%) kasus. Eksisi merupakan metode yang paling sering dipilih yaitu pada 21 (84%) kasus. Kesembuhan klinis setelah 1 bulan paska terapi didapatkan pada 20 (80%) kasus. Simpulan: Tatalaksana kalus dan klavus di URJ Kulit dan Kelamin Divisi TBK RSUD Dr. Soetomo, Surabaya menunjukkan angka kesembuhan sebesar 80% dengan modalitas yang paling banyak dipilih berupa eksisi.

Akurasi kadar serum Secretory Leukocyte Protease Inhibitor (SLPI) dalam menunjang diagnosis kanker ovarium: suatu uji diagnostik Putu Adi Sujana Putra; Ketut Suwiyoga; I Nyoman Gede Budiana; I Wayan Megadhana; I Nyoman Bayu Mahendra; I Made Darmayasa
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Ovarian cancer is one of the most common malignant tumors found in reproductive organs in vitro. Secretory Leukocyte Protease Inhibitor (SLPI) protein is essential for the growth of ovarian cancer cells, a protein that maintains the survival of ovarian cancer cells, inhibits antiproliferative effects, and reverses the proapoptotic effect of elastase. This study aims to evaluate the role of SLPI in diagnosing ovarium cancer. Methods: The research was conducted at the Obstetrics and Gynecology Polyclinic, Sanglah Hospital, Denpasar and the Prodia Laboratory. Sampling of this study has been carried out by previous researchers in research on the accuracy of serum levels of insulin-like growth factor binding protein 2 in diagnosing ovarian cancer. The research sample (intended sample) was women aged 18 years and over with ovarian tumors who came to the Obstetrics and Gynecology Polyclinic, Sanglah Hospital, Denpasar. Data were analyzed using SPSS versi 22 for Windows. Results: The proportion of epithelial types was significantly higher in the ovarian cancer group. In ovarian cancer samples, the most samples were obtained at FIGO III Stage. Median CA125 levels, RMI scores, and SLPI levels were significantly higher in the group with ovarian cancer. The cut off value of serum SLPI used in this study was 54,000 pg/ml which was obtained from preliminary analysis on 26 training samples. Sensitivity: 78.3; specificity:66.7%; Positive predictive value: 78.3%; Negative predictive value: 66.7% Accuracy: 73.6%. Conclusion: In a diagnostic test study to assess the accuracy of SLPI serum in supporting the diagnosis of ovarian cancer, it was found that SLPI serum had good sensitivity, specificity, PPV, NPV, and accuracy values. Latar Belakang: Kanker ovarium merupakan salah satu tumor ganas yang paling sering ditemukan pada organ reproduksi secara in vitro. Protein Secretory Leukocyte Protease Inhibitor (SLPI) sangat esensial untuk pertumbuhan sel kanker ovarium, protein yang menjaga kelangsungan hidup sel kanker ovarium, inhibisi efek antiproliferatif, dan membalikkan efek proapoptosis dari elastase. Penelitian ini bertujuan untuk mengevaluasi peran SLPI dalam mendiagnosis kanker ovarium. Metode: Penelitian dilakukan di Poliklinik Kebidanan dan Penyakit Kandungan RSUP Sanglah Denpasar dan Laboratorium Prodia. Pengambilan sampel penelitian ini sudah dilakukan oleh peneliti sebelumnya pada penelitian tentang akurasi kadar serum insulin-like growth factor binding protein 2 dalam mendiagnosis kanker ovarium. Sampel penelitian (intended sample) adalah wanita berusia 18 tahun ke atas dengan tumor ovarium yang datang ke Poliklinik Kebidanan dan Penyakit Kandungan RSUP Sanglah Denpasar. Hasil: Proporsi tipe epitelial secara signifikan lebih banyak pada kelompok kanker ovarium. Pada sampel kanker ovarium, didapatkan sampel paling banyak pada Stadium FIGO III. Median kadar CA125, skor RMI, dan kadar SLPI secara signifikan lebih tinggi pada kelompok dengan kanker ovarium. Nilai cut off serum SLPI yang digunakan pada penelitian ini adalah 54.000 pg/ml yang didapatkan dari analisa pendahuluan pada 26 training sample Sensitivitas:78,3; spesifisitas:66,7%; Nilai prediksi positif: 78,3%; Nilai prediksi negatif: 66,7% Akurasi: 73,6%. Kesimpulan: Pada penelitian uji diagnostik untuk menilai akurasi serum SLPI dalam menunjang diagnosis kanker ovarium didapatkan bahwa serum SLPI memiliki nilai sensitivitas, spesifisitas, PPV, NPV, dan akurasi yang baik.

Myoepithelial carcinoma of lacrimal gland in HIV patient: A rare case L.P. Suryantini Septia Dewi; Putu Yuliawati; made laksmiNi Made Laksmi Utari; sukartiniA.A.A. Sukartini Djelantik
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Introduction: Lacrimal gland tumors have 1: 1,000,000 cases per year, accounting for one-fourth of lesions that occupy the orbital space. The rarity of lacrimal gland tumors and the many types of tumors with various types of lesions make determining optimal treatment difficult. A myoepithelial tumor is a rare epithelial neoplasm of the lacrimal gland. This paper aims to report a good outcome case of myoepithelial carcinoma. Case Report: A 30-year-old male complained of protruding his left eye since 2014, accompanied by pain and clear white discharge. The vision was getting blurry and also double vision. Patients with Human Immunodeficiency Virus (HIV) disease since 2013 on Anti Retro Viral (ARV) therapy. Right eye visual acuity was 6 / 7.5, and good eyeball examination. The left eye was 6/10 with no pinhole improvement, non-axial proptosis, and superolateral mass. The movement of his left eye was restricted. Other anterior and posterior segments were promising. The patient was diagnosed with pseudotumor and was given oral methylprednisolone. The eye condition is said to be getting better. The patient complained that the left eye was more prominent and protruding three years later, with blurred vision accompanied by infection. Left eye visual acuity becomes Light Perception Bad Projection with non-axial proptosis, retraction of palpebra and pus. Orbital exenteration was performed, and anatomical pathology examination revealed myoepithelial carcinoma of the lacrimal gland. The patient was planned for radiotherapy. Conclusion: These rare cases have made setting up a regimen in randomized controlled trials difficult. The rapid development of therapy gives more hope to treating patients with lacrimal gland tumors.

Hubungan antara kadar homosistein (Hcy) dengan kejadian ketuban pecah dini (KPD) pada kehamilan preterm Agrifa Eko Albert Sembiring; Tjokorda Gde Agung Suwardewa; Ketut Surya Negara; I Nyoman Gede Budiana; Ida Bagus Putra Adnyana; Evert Solomon Pangkahila
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Premature rupture of membranes (PROM) has been a problem in obstetrics since ancient times until now. The incidence of PROM in the world ranges from 5% - 15% of all pregnancies, while the incidence in developing countries, especially Indonesia ranges from 4.5% to 7.6% of all pregnancies. Preterm is one of the highest contributors to perinatal mortality and morbidity. The incidence of preterm pregnancy in the world is around 9.6% of all births, while in Southeast Asia is around 11.1% It has been shown to have a significant effect on vascular endothelial pathology. Methods: The study was conducted with an analytic cross-sectional design involving 70 respondents of pregnant women with gestational age of 20 - < 37 weeks with and without PPROM who came to the outpatient clinic and maternity ward of Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar from May 2021 – July 2021. Results: The results of the analysis of this study found a statistically significant relationship between homocysteine (Hcy) levels and the incidence of preterm premature rupture of membranes (p = 0.001). The prevalence ratio value of 2.2 means that high homocysteine levels is a risk factor for premature rupture of membranes in preterm pregnancy (RP = 2.2; 95% CI = 1.33-2.94; p = 0.001). Conclusion: High homocysteine level is a risk factor for premature rupture of membranes in preterm pregnancy. Latar Belakang: Ketuban pecah dini (KPD) preterm merupakan masalah di bidang obstetrik sejak dahulu sampai sekarang. Insiden KPD di dunia berkisar antara 5% - 15% dari seluruh kehamilan. Insiden KPD di negara berkembang khususnya Indonesia berkisar 4,5% - 7,6% dari seluruh kehamilan. Kehamilan preterm menjadi salah satu penyumbang tertinggi angka mortalitas dan morbiditas perinatal. Insiden kehamilan preterm di dunia sekitar 9.6% dari semua kelahiran, sedangkan di Asia tenggara terdapat sekitar 11,1%. Hcy telah terbukti signifikan berpengaruh pada patologi endotel pembuluh darah. Metode: Penelitian dilakukan dengan rancangan cross sectional analitik dengan melibatkan 70 responden wanita hamil dengan usia gestasi 20 - <70 minggu dengan atau tanpa KPD yang dating ke poliklinik dan ruang bersalin RSUP Prof. Dr. I.G.N.G. Ngoerah bulan Mei 2021 – Juli 2021. Hasil: Diperoleh hubungan bermaksana secara statistik antara kadar homocycteine dengan kejadian ketuban pecah dini pada kehamilan preterm (p = 0, 001), dan rasio prevalensi 2,2 berarti kadar homosisteine yang tinggi merupakan faktor risiko terjadinya ketuban pecah dini pada kehamilan preterm (RP = 2.2; 95% CI = 1.33-2.94; p = 0.001). Kesimpulan: Kadar homosistein yang tinggi merupakan faktor risiko terjadinya ketuban pecah dini pada kehamilan preterm.

Rasio platelet-limfosit serum ibu pada kehamilan preterm dan kehamilan preterm dengan Ketuban Pecah Dini (KPD): suatu studi potong-lintang Tjokorda Gde Agung Suwardewa; Anak Agung Gede Putra Wiradnyana; Made Suyasa Jaya; I Nyoman Bayu Mahendra; Ryan Saktika Mulyana; Alfonso Anggriawan
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Preterm Premature Rupture of Membranes (PPROM) is one of the obstetric problems that needs special attention, apart from the high prevalence, cases of PPROM also often cause neonatal morbidity and mortality. Inflammation is thought to be the cause of the incidence of PPROM and has a relationship with the incidence of ascending genital tract infection. The physiological immune response to inflammation is characterized by an increase in the number of circulating platelets and a decrease in the number of lymphocytes. This study aims to evaluate the high ratio of platelets to lymphocytes of maternal blood serum is a risk factor for the occurrence of preterm PROM. Methods: This study is a cross-sectional study with a sample size of 70 samples, and is divided into a risk group (preterm pregnancy with PROM) and a no-risk group (preterm pregnancy without PROM). This research was conducted in the Emergency Room maternity ward and Obstetrics and Gynecology outward patient at Sanglah Hospital Denpasar for the period December 2020 to May 2021. Data were analyzed using SPSS version 26 for Windows. Results: The results of the analysis of this study obtained a statistically significant difference (p = 0.000). The group with a high maternal blood serum platelet to lymphocyte ratio had a higher risk of developing preterm PROM compared to the group with a low maternal blood serum platelet to lymphocyte ratio (PR = 2.4, 95% CI = 1.60-3.69, p = 0.000). Conclusion: The conclusion of this study is the high maternal blood serum platelet to lymphocyte ratio is a risk factor for the occurrence of preterm PROM. Latar Belakang: Ketuban pecah dini (KPD) preterm merupakan salah satu masalah obstetri yang perlu mendapat perhatian khusus, selain karena prevalensi yang besar, kasus KPD preterm juga sering menyebabkan morbiditas dan mortalitas neonatus. Inflamasi diduga sebagai penyebab dari kejadian KPD preterm dan mempunyai hubungan dengan kejadian infeksi ascending traktus genital. Respon imun fisiologis terhadap inflamasi ditandai oleh peningkatan jumlah platelet yang beredar dan penurunan jumlah limfosit. Penelitian ini bertujuan untuk mengetahui bahwa tingginya rasio platelet terhadap limfosit serum darah ibu merupakan faktor risiko terjadinya KPD preterm. Metode: Penelitian ini merupakan penelitian cross-sectional dengan jumlah sampel sebanyak 70 sampel, dan terbagi menjadi kelompok berisiko (kehamilan preterm dengan KPD) dan kelompok tanpa risiko (kehamilan preterm tanpa KPD). Penelitian ini dilakukan di kamar bersalin IGD serta Poli Obstetri dan Ginekologi RSUP Sanglah Denpasar periode Desember 2020 hingga Mei 2021. Data dianalisis dengan SPSS versi 26 untuk Windows. Hasil: Hasil analisis dari penelitian ini didapatkan perbedaan yang bermakna secara statistik (p = 0,000). Kelompok dengan nilai rasio platelet terhadap limfosit serum darah ibu yang tinggi memiliki risiko mengalami kejadian KPD preterm dibandingkan dengan kelompok dengan rasio platelet terhadap limfosit serum darah ibu yang rendah (PR = 2,4, IK 95% = 1,60-3,69, p = 0,000). Kesimpulan: Simpulan dari penelitian ini adalah rasio platelet terhadap limfosit serum darah ibu yang tinggi merupakan faktor risiko terjadinya kejadian KPD preterm.

Page 2 of 6 | Total Record : 57

1 2 3 4 5

Filter by Year

2022 2022

Filter By Issues

All Issue Vol. 13 No. 3 (2022): (In Press 1 December 2022) Vol. 13 No. 2 (2022): (In Press : 1 August 2022) Vol. 13 No. 1 (2022): (Available Online : 1 April 2022) Vol. 12 No. 3 (2021): (Available online: 1 December 2021) Vol. 12 No. 2 (2021): (Available Online: 1 August 2021) Vol. 12 No. 1 (2021): (Available online : 1 April 2021) Vol. 11 No. 3 (2020): (Available online: 1 December 2020) Vol. 11 No. 2 (2020): (Available online: 1 August 2020) Vol. 11 No. 1 (2020): (Available online: 1 April 2020) Vol. 10 No. 3 (2019): (Available online: 1 December 2019) Vol. 10 No. 2 (2019): (Available online: 1 August 2019) Vol. 10 No. 1 (2019): (Available online 1 April 2019) Vol. 9 No. 3 (2018): (Available online: 1 December 2018) Vol. 9 No. 2 (2018): (Available online: 1 August 2018) Vol. 9 No. 1 (2018): (Available online: 1 April 2018) Vol. 8 No. 3 (2017): (Available online: 1 December 2017) Vol. 8 No. 2 (2017): (Available online: 1 August 2017) Vol. 8 No. 1 (2017): (Available online: 1 April 2017) Vol. 7 No. 1 (2016): (Available online: 1 December 2016) Vol. 6 No. 1 (2016): (Available online: 1 August 2016) Vol. 5 No. 1 (2016): (Available online: 1 April 2016) Vol. 4 No. 1 (2015) Vol. 3 No. 1 (2015) Vol. 2 No. 1 (2015) Vol. 1 No. 1 (2014) More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota denpasar,

Bali

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota denpasar,

Bali

INDONESIA