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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Search results for , issue "Vol. 13 No. 2 (2022): (In Press : 1 August 2022)" : 57 Documents clear

Osteomielitis kronis yang terabaikan selama 15 tahun pada usia dewasa: laporan kasus I Putu Oka Buda Yadnya; Anak Agung Ngurah Ronny Kesuma; I Komang Agus Krisna Saputra; I Komang Mahendra Laksana Mendra
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Osteomyelitis has its challenges in its management. Not only because it requires time and cost in treatment, but also a collaboration between doctors, the patient and the environment of family and significant person to the patient himself to achieve optimal management. Case Description: This report was conducted to find the therapy results in a patient with a diagnosis of chronic osteomyelitis, which has suffered the patient for 15 years. This study used a case reports study. Therapy given to the 29 years old male patient with a diagnosis of chronic osteomyelitis of the right femur Cierny Mader IVA was debridement and incision, as well as giving empirical antibiotics according to culture results. The result of the treatment was satisfactory. Conclusion: The patient’s condition improved, and no complaints were reported. The patient can do activities with an assistive device. Latar Belakang: Osteomielitis memiliki tantangan tersendiri dalam penatalaksanaanya, selain karena membutuhkan waktu dan biaya dalam pengobatan, dibutuhkan kerjasama antara dokter, pasien dan lingkungan baik itu keluarga ataupun orang terdekat pasien itu sendiri agar dapat mencapai penatalaksanaan yang optimal. Deskripsi Kasus: Laporan ini bertujuan untuk mengetahui hasil pemberian terapi pada pasien dengan diagnosa osteomielitis kronis yang sudah diderita oleh pasien sejak 15 tahun yang lalu. Penelitian ini menggunakan metode laporan kasus. Terapi yang diberikan kepada pasien laki-laki 29 tahun dengan diagnosa osteomielitis kronis femur kanan cierny mader IVA berupa debridemen dan insisi, disertai pemberian antibiotik empirik sesuai hasil kultur. Hasil dari pemberian terapi tersebut cukup memuaskan. Kesimpulan: Pasien mengalami perbaikan kondisi dan tidak didapatkan keluhan serta pasien dapat beraktifitas dengan alat bantu

Effect of uncontrolled glycemic on cataract surgery outcome in patient with diabetic retinopathy NLP Wistya Eka Mahadewi; I Wayan Gede Jayanegara; Siska; I Made Agus Kusumadjaja
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Objective: This study aims to report a case of catarct surgey outcome in cataract diabetic patient with uncontrolled glycemic. Case Presentation: A 54-year-old woman has catarct on both eye and history of diabetes mellitus for 15 years. The patients was planned for cataract surgery when blood sugar below 200mg/dL in left eye,blood sugar patients from 248 mg/dL become 168 mg/dL. One week post operation evaluation revealed corneal edema, due to phaco time intra surgery in this patient increased. Visual acuity was 6/120 BCVA on the right eye and 6/18 BCVA on the left eye. Visual acuity has decreased in 2 months after surgery, 1/60 BCVA on the right eye and 6/18 BCVA on the left eye, as well as funduscopy presence of dot blot, flame-shaped, and traction on both eyes. This outcome was contributed by an uncontrolled blood glucose of the patient. Conclusion: Preoperative preparations in diabetic cataract patients are mandatory, including blood sugar and HbA1C control, to achieve a better outcome of ocular surgery in patients with diabetes mellitus.

Ablasio retina rhegmatogen bilateral: sebuah laporan kasus Amicipta Sanjaya; Ari Andayani; I Made Agus Kusumadjaja
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Rhegmatogenous retinal detachment in children is rare, accounting for less than ten percent of all rhegmatogenous retinal detachments. While the majority of retinal detachments in the adult population are associated with posterior vitreous detachments, pediatric rhegmatogenous retinal detachments are often associated with trauma or an underlying congenital abnormality, although in some cases they are associated with idiopathic conditions. Case Description: A 16-year-old male patient complained about blurry vision in the right eye in the last 6 months and in the left eye in the last 5 months. Ophthalmology examination in the right eye found an inferior retinal detachment (+) at 3-9 o’clock, multiple breaks at 7-9 hours, PVR grade C, subretinal fibrosis (+), traction (+), macula off, RM (-). Meanwhile, ophthalmology examination in the left eye found an inferior retinal detachment in the left eye (+) at 3-9 o’clock, break at 5 o'clock, PVR grade C, traction (+), RM (+). The patient underwent pars plana vitrectomy in both eyes and the patient experienced an increase in visual acuity after surgery on both eyes. Conclusion: This case describes a healthy adolescent male with bilateral rhegmatogenous retinal detachment secondary to spontaneous non-traumatic retinal dialysis. The Pars Plana Vitrectomy (VPP) technique that used in this case could give high final reattachment rate and relatively good functional outcomes. VPP also has the intraocular ability to manipulate tissues and reduce immediate vitreous traction. Latar Belakang: Ablasio retina rhegmatogenous pada anak-anak jarang terjadi, terhitung kurang dari sepuluh persen dari semua ablasio retina rhegmatogen. Sementara sebagian besar ablasio retina pada populasi orang dewasa terkait dengan ablasio vitreous posterior, ablasio retina hegmatogen pediatrik sering kali berhubungan dengan trauma atau kelainan kongenital yang mendasari, walaupun pada beberapa kasus didapatkan dengan kondisi idiopatik. Laporan Kasus: Pasien laki-laki berusia 16 tahun mengeluhkan penurunan pengelihatan pada mata kanan sejak 6 bulan sebelumnya dan pada mata kiri 5 bulan sebelumnya. Pemeriksaan oftalmologi didapatkan AAR di mata kanan dengan retinal detachment (+) di inferior pada jam 3-9, multiple break pada jam 7-9, PVR grade C, fibrosis subretina (+), traksi (+), macula off, RM (-). Pemeriksaan pada mata kiri didapatkan retinal detachment di mata kiri (+) di inferior pada jam 3-9, break pada jam 5, PVR grade C, traksi (+), RM (+). Pasien menjalani vitrektomi pars plana pada kedua mata dan pasien mengalami peningkatan tajam penglihatan setelah dilakukan tindakan operasi pada kedua mata. Kesimpulan: Kasus ini menjelaskan remaja laki-laki sehat dengan bilateral ablasio retina rhegmatogen sekunder akibat retinal spontan non-trauma dialisis. Teknik Vitrektomi Pars Plana (VPP) digunakan pada kasus ini dan mampu memberikan tingkat attachment akhir yang tinggi dan hasil fungsional yang relatif baik serta kemampuan intraokular untuk memanipulasi jaringan dan mengurangi traksi vitreous secara langsung.

The role of tumor necrosis factor-alpha (TNF-α) inhibitor in steven johnson syndrome/toxic epidermal necrolysis (SJS/TEN) management: a systematic review Icasia Yuseli Kurnia
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background. Steven Johnson Syndrome and Toxic Epidermal Necrolysis are dermatologic emergencies with high mortality rates characterized by extensive skin involvement. TNF-α has a role in inducing the production of granulysin that enhances keratinocyte cell death. Thus, the use of TNF-α inhibitors such as etanercept and infliximab is promising to halt the disease progression. This systematic review aims to evaluate the efficacy of TNF-α inhibitor in SJS/TEN management. Method. A systematic review using an online database was conducted based on PRISMA guidelines. Inclusion criteria were studied about the role of TNF-α inhibitor in SJS/TEN management. The exclusion criteria were a letter to the editor, commentary report, review, meta-analysis, study not used humans as a study subject, not available in full text and not in English or Bahasa Indonesia. Result. Fourteen studies are included in this systematic review consisting of ten case reports, three cohort retrospective studies, and one randomized controlled trial. TNF-α inhibitors such as etanercept and infliximab are beneficial for SJS/TEN management because they accelerate skin healing time and re-epithelization, reduce in-hospital duration and mortality rate, and minimal complications and side effects. TNF-α inhibitors should be given quickly after the disease onset, and combination with other immunosuppressive agents should be avoided to prevent the excessive immunosuppressive effect. Conclusion. TNF-α inhibitors such as etanercept and infliximab promise therapy to halt SJS/TEN progression.

Prevalensi cemaran patogen Salmonella pada daging babi yang dijual di Pasar Tradisional di Kota Denpasar I Gusti Agung Istri Gladys Elsyaningrat; Komang Januartha Putra Pinatih; Ni Nengah Dwi Fatmawati; Agus Eka Darwinata
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Food contamination is a serious problem. Salmonella sp is one of the main bacteria causing gastrointestinal disease, especially in raw pork, due to the production and distribution process. Traditional markets have high risk of pathogenic microbial contamination. The purpose of this study was to detect contamination of Salmonella sp. on pork sold in traditional markets, particularly in Denpasar, Bali. Method: This research is a cross-sectional descriptive, with the samples coming from the porks sold by traditional market traders in every sub-district in Denpasar, Bali. The sampling technique used is the cluster purposive sampling. The procedure for identification of Salmonella sp. using culture and subculture examination on Salmonella Shigella Agar (SSA), simmon citrate agar media, and identification of the microscope. Results: Based on SSA culture results from 38 samples, 26 samples of pork showed colony growth, but only 10 samples with typical morphology of Salmonella sp. The 16 samples with atypical morphology were examined for SSA subculture, with 9 samples having clear black colonies. In 19 research samples that showed the results were suspected to be contaminated with Salmonella sp. continued to the Simmons citrate test, but only 8 samples were positive. The 19 samples were also examined under a microscope and all samples showed a rod image and red color indicating that the colonies in the sample were gram-negative bacilli which are typical of the morphology of Salmonella sp. Conclusion: Contamination of Salmonella was found in pork sold at Traditional Markets in Denpasar with a prevalence of 21%. Latar belakang: Kontaminasi makanan merupakan suatu masalah serius. Salmonella sp merupakan salah satu bakteri penyebab utama penyakit gastrointestinal, terutama pada daging babi mentah, dikarenakan pada proses produksi dan distribusi. Pasar tradisional merupakan tempat yang sangat rawan dan beresiko cukup tinggi terhadap cemaran mikroba patogen. Tujuan penelitian ini adalah mendeteksi ada tidaknya cemaran bakteri Salmonella sp. pada daging babi yang dijual di Pasar Tradisional, khususnya di Denpasar, Bali. Metode: Penelitian ini merupakan deskriptif potong lintang, dengan sampel penelitian berupa daging babi yang dijual oleh pedagang pasar tradisional di setiap kecamatan di Kota Denpasar, Bali. Teknik penentuan sampel yang digunakan yaitu teknik cluster purposive sampling. Prosedur identifikasi kontaminasi Salmonella sp. menggunakan pemeriksaan kultur serta subkultur pada Salmonella Shigella Agar (SSA), Kultur pada media simmon citrate agar, dan identifikasi mikroskop. Hasil: Berdasarkan hasil kultur SSA dari 38 sampel daging babi, 26 sampel daging babi menunjukan adanya pertumbuhan koloni, namun hanya 10 sampel dengan morfologi khas Salmonella sp. Pada 16 sampel dengan morfologi tidak khas dilakukan pemeriksaan subkultur SSA, dengan 9 sampel memiliki warna koloni hitam bening. Pada 19 sampel penelitian yang menunjukan hasil terduga terkontaminasi Salmonella sp. dilanjutkan ke uji Simmons citrate, namun hanya 8 sampel dengan hasil positif. Pada 19 sampel juga dilakukan pemeriksaan mikroskop dan seluruh sampel menunjukkan gambaran batang serta berwarna merah yang menandakan bahwa koloni pada sampel adalah basil gram negatif yang khas pada morfologi bakteri Salmonella sp. Kesimpulan: Terdapat cemaran patogen Salmonella sp. pada daging babi yang dijual di Pasar Tradisional di Denpasar dengan prevalensi sebesar 21%.

Pengaruh ekstrak etanol umbi ubi jalar ungu terhadap kadar dopamin striatum dan perilaku stereotipi pada tikus wistar yang diinduksi methylphenidate Putu Asih Primatanti
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Anthocyanins are flavonoids that have various potentials such as antioxidant, anti-inflammatory and antiapoptotic. One source of anthocyanins which is common among the Indonesian are purple sweet potato (Ipomoea batatas L.). Its potential can be used to prevent and treat the effects of substances including psychostimulants. Methylphenidate (MPH) is one of the psychostimulants used as therapeutic option for ADHD, but its use has several controversies, such as the occurrence of toxicity and long-term damage. This study aimed to examine the effect of purple sweet potato ethanol extract on levels of the striatum dopamine neurotransmitter and stereotypic behavior in methylphenidate-induced rats. Method: This research is a randomized posttest–only control group. Samples were male Wistar rats (Rattus norvegicus), aged 6-8 weeks (randomly divided into 2 groups). The treatment group was given purple sweet potato ethanol extract before MPH injection. Examination of dopamine levels using ELISA and stereotyped behavior were assessed using the stereotyped behavior rating scale. Statistical test was by Mann Witney test and independent t-test. Results: The results showed striatum dopamine levels were significantly lower in the treatment group (given purple sweet potato ethanol extract before MPH was induced) than the control (6.83±2.83 vs. 10.02±4.35; p<0.05). Stereotypic behavior in the treatment group was significantly lower than the control group (3.46±0.63 vs. 3.96±0.70; p<0.05). Conclusion: The ethanolic extract of purple sweet potato is thought to have antidopaminergic potential and cause a decrease in stereotypic behavior in MPH-induced wistar rats. Latar belakang: Antosianin merupakan flavonoid yang memiliki berbagai potensi seperti antioksidan, antiinflamasi dan antiapoptosis. Salah satu sumber antosianin yang mudah ditemukan dan cukup umum di kalangan penduduk lokal Indonesia adalah ubi jalar ungu (Ipomoea batatas L.). Potensinya dapat mencegah dan mengobati dampak yang ditimbulkan oleh zat psikostimulan. Methylphenidate (MPH) merupakan salah satu psikostimulan yang digunakan sebagai pilihan terapi untuk Attention-deficit hyperactivity disorder (ADHD), namun pemakaiannya memiliki beberapa kontroversi seperti terjadinya efek toksik, penyalahgunaan dan timbulnya kerusakan jangka panjang. Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak etanol ubi jalar ungu terhadap kadar neurotransmiter dopamin striatum dan perilaku stereotipi pada tikus yang diinduksi methylphenidate. Metode: Rancangan penelitian yang digunakan yaitu randomized posttest–only control group. Sampel penelitian adalah tikus (Rattus norvegicus) galur Wistar jantan, berumur 6-8 minggu (secara random dibagi dalam 2 kelompok). Kelompok perlakuan diberikan ekstrak etanol ubi jalar ungu sebelum diinjeksi MPH, sedangkan kelompok kontrol tidak. Pemeriksaan kadar dopamin menggunakan teknik Elisa dan perilaku stereotipi dinilai memakai stereotyped behavior rating scale. Uji statistik menggunakan uji mann witney dan independent t-test. Hasil: Hasil penelitian menunjukkan kadar dopamin striatum lebih rendah secara bermakna pada kelompok perlakuan (diberikan ekstrak etanol ubi jalar ungu sebelum diinduksi MPH) dibandingkan kontrol (6,83±2,83 vs. 10,02±4,35; p<0,05). Perilaku stereotipi pada kelompok perlakuan lebih rendah secara signifikan dibandingkan kontrol (3,46±0,63 vs. 3,96±0,70; p<0,05). Kesimpulan: Ekstrak etanol ubi jalar ungu diperkirakan memiliki potensi antidopaminergik dan menyebabkan penurunan perilaku stereotipi pada tikus wistar yang diinduksi MPH.

Pengaruh kadar gula darah puasa terhadap ekspresi Glucose transporter type-4 (GLUT4) neuron hipokampus pada tikus model diabetes Ngakan Putu Proudy Laksmana; Rizka Vidya Lestari; Muhammad Ghalvan Sahidu; Ilsa Hunaifi; Herpan Syafii Harahap; Novrita Padauleng; Nurhidayati
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Diabetes mellitus causes many complications, both microvascular and macrovascular, especially cognitive function. Related studies are being carried out to determine the relationship between diabetes and cognitive decline as assessed through GLUT4 expression in the hippocampus. The aimed of this study was to determine the effect of fasting blood sugar on hippocampal neuronal GLUT4 expression in STZ and NA-induced diabetic rats. Methods: This study was an experimental design, using 24 males Rattus novergicus which were divided into a control group terminated on day 14 (A0) and 28 (B0) and a diabetes group terminated on day 14 (A1) and 28 (B2). Diabetes was induced using intraperitoneal injection of streptozotocin (STZ) and Nicotinamide (NA). Spatial memory (travel time) of rats was assessed on days 14 and 28. Sampling used secondary data, fasting blood glucose (FBG) was measured using a glucometer and brain tissue was taken to assess GLUT4 expression using immunohistochemical methods. Differences in the mean FBG and GLUT4 expression between groups on days 14 and 28 and were tested statistically using SPSS version 22 Results: The mean FBG and GLUT4 expression in the diabetic group were significantly higher than those in the control group on day 14 and day 28. However, it was not significant compared between diabetes groups on day 14 and day 28. Immunohistochemical examination confirmed these results. There is a strong correlation between mean FBG levels and mean GLUT4 expression with travel time in the diabetes group on days 14 and 28 (r=0.88, p<0.05). Conclusion: Fasting blood glucose levels significantly affected hippocampal neuronal GLUT4 expression in STZ and NA-induced diabetic rats. Latar belakang: Diabetes mellitus banyak menimbulkan komplikasi serius baik mikrovaskuler dan makrovaskuler, khususnya pada fungsi kognitif. Studi terkait sedang terus dilaksanakan untuk mengetahui hubungan terkait antara kondisi diabetes dengan penurunan fungsi kognitif yang dinilai memalui ekspresi GLUT4 di hippocampus. Tujuan dari penelitian ini adalah untuk mengevaluasi pengaruh kadar gula darah puasa terhadap ekspresi GLUT4 neuron hipokampus pada tikus model diabetes. Metode: Penelitian dengan desain eksperimental, menggunakan 24 ekor Rattus novergicus jantan yang dibagi menjadi kelompok kontrol yang diterminasi pada hari ke-14 (A0) dan 28 (B0) dan kelompok diabetes yang diterminasi pada hari ke-14 (A1) dan 28 (B2). Diabetes diinduksi menggunakan suntikan streptozotocin (STZ) dan Nikotinamid (NA) secara intraperitoneal. Memori spasial (waktu tempuh) tikus dinilai pada hari ke-14 dan 28. Pengambilan sampel menggunakan data sekunder, gula darah puasa (GDP) diukur menggunakan glucometer dan pengambilan jaringan otak dilakukan untuk penilaian ekspresi GLUT4 menggunakan metode imunohistokimia. Perbedaan rerata GDP dan ekspresi GLUT4 antar kelompok pada hari ke-14 dan 28 serta dilakukan uji secara statistik menggunakan SPSS versi 22. Hasil: Rerata GDP dan ekspresi GLUT4 pada kelompok diabetes secara signifikan lebih tinggi dibandingkan dengan kontrol pada hari ke-14 maupun hari ke 28. Akan tetapi tidak signifikan dibandingkan antar kelompok diabetes pada hari ke-14 dengan hari ke-28. Pemeriksaan imunohistokimia mengkonfirmasi hasil ini. Terdapat korelasi yang kuat pada hubungan yang rerata kadar GDP dengan rerata ekspresi GLUT4 dengan waktu tempuh pada kelompok diabetes pada hari ke-14 dan 28 (r=0,88, p<0,05). Simpulan: Kadar gula darah puasa berpengaruh secara signifikan terhadap ekspresi GLUT4 neuron hipokampus pada tikus model.

Botox injection for anal fissure management: case report Gede Eka Rusdi Antara
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Introduction: Anal fissure is shallow tear in the anoderm distal to dentate line which is considered most common proctologic condition. Anal fissure is generally located in the posterior midline. The symptoms include anal pain, spasm, and/or bleeding during defecation1. The pain can be so intense as to induce the patient to avoid defecation with consequent hardening of the feces and exacerbation of the problem2. Management of the anal fissure is improving diet and defecation habit, medical therapy and surgical therapy. The goal of medical treatment for chronic anal fissure is to temporarily reduce pressure of the anal canal to facilitate the healing of the fissure (“reversible sphincterotomy”), thereby reducing muscle tone. Intrasphincteric Botulinum Toxin A injection seems to be a reliable option. Case reports: two male patients were diagnosed with anal fissures, the patients complained of pain and spasm. They were treated with botulinum toxin type A (100 unit AllergenÒ), injected into three sites of the internal sphincter at 2, 5 and 8 o’clock. The symptoms relieved and the anal fissure healed within one month. There was no sign of relapse or incontinence during 12 months of follow-up. Conclusion: Botulinum toxin therapy can be considered as efficacious, effective and safe treatment for anal fissures. Keywords: anal fissure, botox, botulinum toxin, intrasphincteric

Nonsteroid anti-inflammatory drug choices in patients with juvenile idiopathic arthritis: A systematic review Yogi Priyatna Biantara; Surya Fajari Widhiarma; Widia Trilaksana Kusuma
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Disease-modifying anti-rheumatic drugs (DMARDs) are still a priority in treating juvenile idiopathic arthritis (JIA). The choice of drug therapy for the NSAIDs as an alternative to the therapy used in managing JIA cases due to the side effects of DMARDs. However, the former discussion of the choices therapy of NSAID therapy in JIA patients is still limited. This systematic review was conducted to present any choices of NSAIDs used for the treatment JIA and presented their effectiveness and adverse reaction compared with other NSAIDs used for treating JIA. Methods: Comprehensive electronic searches were performed in PubMed/Medline, EMBASE, and Cochrane Library, choosing Randomized Controlled Trials of NSAIDs for treating children with JIA up to January 2009. The risk of bias was assessed using the Cochrane Risk of Bias Tools for randomized controlled trials. Results: Eight eligible randomized controlled trials (RCT) out of 1309 studies were included, with a total of 1112 participants with JIA identified, addressing 19 kinds of interventions with nine types of medications. First RCT concluded that Celecoxib 3 mg/kg and Celecoxib 6 mg/kg were at least as effective as naproxen 7.5 mg/kg in terms of reducing clinical symptoms of arthritis and joint swelling. Second RCT concluded that Low Dose (0,3 mg/kg) and High Dose (0.6mg/kg) Rofecoxib showed a greater improvement than the Naproxen group to relieve the pain. The third RCT stated that good efficacy or satisfaction is most frequent in the participant with Meloxicam 0.125 mg/kg rather than Meloxicam 0.25 mg/kg or Naproxen 10 mg/kg. Fourth RCT concluded that Ibuprofen 30-40 mg/kg/d is an effective agent for symptomatic treatment of JIA and is well-tolerated in many children. Fifth RCT informed that Piroxicam show more effective in controlling the symptoms and improving function than Naproxen 10 mg/kg/day. Sixth RCT concluded that Acetylsalicylic acid 75 mg/kg/day has better efficacy than Naproxen 10 mg/kg/d in relieving the symptoms. The seventh study stated that both diclofenac sodium 2-3 mg/kg/day and acetylsalicylic acid 50-100 mg/kg/d at least as good as placebo. The last RCTs study stated that tolmetin 15 mg/kg/day decreased the duration of morning stiffness and reduced joint pain. Also, aspirin 50mg/kg/day resulted in ROM improvement in JIA patients. Conclusions: We present Celecoxib, Rofecoxib, Meloxicam, Ibuprofen, Piroxicam, Acetylsalicylic Acid (ASA), Diclofenac Sodium, Tolmetin Sodium, and Naproxen as the NSAIDs choice drugs on pediatric patient diagnosed with JIA. which has each adverse event on each therapy.

Comparison of knee society scores in osteoarthritis patient before and after total knee arthroplasty: a case report I Dewa Gede Indra Pratama Putra; Dewa Gede Kurnia Pratama; Putu Budi Sucitra
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Introduction: Osteoarthritis is a degenerative disease characterized by joint pain in the cartilage. It requires further management, especially in severe conditions that have not responded to pharmacological therapy, such as Total Knee Arthroplasty (TKA). Therefore, the authors aim to compare the knee quality of patients with Knee Society Scores (KSS) before and after TKA surgery. Case description: Female patient, 55 years old, came with the chief complaint of stiffness and pain in both knees for the last two years. The patient had previously undergone regular treatment and is now getting worse. The radiological found the impression of right and left knee osteoarthritis was grade IV, and the KSS assessment results were 40. The patient was then treated with TKA surgery. After the total knee arthroplasty procedure was observed for one month, the patient had no complaints of joint stiffness and did not feel severe pain in both knees. The KSS assessment results were 71 with good interpretation results. Conclusion: There was an improvement in the knee quality of patients with KSS before and after TKA surgery.

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