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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 36 Documents
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Search results for , issue "Vol 4, No 1 (2022): Volume 4 Edisi 1 2022" : 36 Documents clear
FRAKSI EKSTRAK ETANOL BUAH PARE (Mommordica charantia L.) SEBAGAI ANTIINFLAMASI TERHADAP KADAR TUMOR NECROSIS FACTOR ALPHA (TNF-α) Parawansah Parawansah; Nuralifah Nuralifah; Yulfa Yulfa
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13484

Abstract

Dyslipidemia is an abnormality of lipids in the blood, including a decrease in HDL levels and an increase in triglyceride levels, LDL levels and total cholesterol. The high concentration of cholesterol in the blood is one of the causes of atherosclerosis and can further cause hypertension and coronary heart disease. The use of synthetic drugs in the long term can cause unwanted side effects. This study aims to examine the effect of increasing HDL cholesterol levels, decreasing total cholesterol and LDL cholesterol levels from the ethanol extract of Clitoria ternatea L using male rats (Rattus norvegicus). This study used the maceration method of Clitoria ternatea L. then the thick extract obtained was tested for its activity which was divided into 6 treatment groups namely normal control group, positive control, negative control, dose 1 (extract 100 mg/kgBB), dose 1 2 (extract 200 mg/kgBB) and dose 3 (extract 400 mg/kgBB) were then measured for total cholesterol, HDL and LDL. The results showed that the administration of ethanol extract of Clitoria ternatea L was able to reduce total cholesterol levels, LDL and increase HDL levels in male rats. The dose of ethanol extract of Clitoria ternatea L that was most effective in reducing total and LDL cholesterol levels and increasing HDL levels in rats that had been induced by a high-fat diet was dose 3, namely extract 400mg/kgBB.
Analisis Cemaran Bakteri Coliform Pada Minuman Jajanan Dengan Metode MPN (Most Probable Number) Ervina Surnianingsi Jufri; Ismail Rahman
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13595

Abstract

Coliform bacteria contamination of food and beverages may result from various causes, one of which is faecal contamination, leading to serious health issues. Drinking water contamination of coliform bacteria 50/100 mL has been found to be responsible for diarrhea episode. Local regulation has determined the cut-off point of its contamination within commercial beverages not to exceed 3/mL. No such study has ever been conducted in Ternate. To determine the exact value of coliform bacteria within street beverages sold in various city parks in Ternate. This descriptive was carried out through laboratory testing of street beverages obtained from various city parks in Ternate. The most probable number test for coliform bacteria was carried out at the Technical Implementation Unit, Basic and Integrated Laboratory, North Maluku from December 2021-January 2022. The presumption test and the affirmation test were conducted accordingly. From 22 instant powdered ice drinks samples obtained from Toboko, Falajawa 1, Nukila, Landmark, and Film Benteng parks, 90,9% contained coliform bacteria exceeding the cut-off value. Coliform bacteria contamination in the city parks within Ternate has exceeded the quality standard threshold based on Indonesian National Standard 7388 of 2009. Further research is needed to confirm this.
Hubungan Kepatuhan Konsumsi Tablet Zat Besi dengan Kejadian Anemia Ibu Hamil Ginanjar Zukhruf Saputri; Ana Hidayati; Susan Fitria Candradewi; Sulfah Sulfah
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13540

Abstract

Anemic in Pregnancy is still a health problem in Indonesia. Iron supplementation is a preventive measure carried out by the government in primary health services. However, the average coverage of national Fe tablets is still not maximal (85.1%). Research related to adherence to iron supplement consumption is still limited, therefore this study aims to determine the relationship between adherence level with anemia of pregnant women. The study used an analytic observational method with a cross sectional approach, conducted in the period August-November 2019 at Jetis I Bantul, primary health service Yogyakarta. A total of 39 respondents who met the inclusion criteria and agreed to informed consent were recruited in this study. Data on the level of compliance were taken through interviewing respondents using quistionnaire and pill count, at least on the 7th day after consuming iron tablets, while Hb levels were taken from medical records and examination of respondents. Statistical analysis was performed using chi square. Results showed that 61.5% of pregnant women complied with the consumption of iron tablets, while the measurement of the pill count showed 59.0% has complience. There was a significant correlation between the consumption of iron tablets and the incidence of pregnancy anemia, both adherence to the questionnaire measurement p = 0.000; OR = 0.050; (CI: 0.010-0.263), or the measurement of pill count p = 0.003; OR = 0.126 (CI: 0.030-0.538). A total of 15.4% of pregnant women have anemia in the 2nd trimester of gestation, and 25.6% in the 3rd trimester. Based on this study, it is concluded that there is a correlation between the level of adherence  of  Iron tablet consumption towards the incidence of anemia in pregnant women.
Formulasi dan Uji Stabilitas Hand Body Lotion dari Ekstrak Etanol Rumput Laut (Eucheuma cottonii) Yusnita Usman
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13519

Abstract

Research  has been carried out on formulation and stability test of hand body lotion from ethanolic extract of seaweed (Euchema cottonii). This study aims to obtain a hand body lotion formulation from seaweed extract (Eucheuma cottonii) that meets the requirements for the physical quality of the lotion, where the formula made consists of 4 formulas with extract concentrations of 5%, 10%, 15% and formulas without extracts. The evaluation of lotion preparations included organoleptic tests, pH tests, homogeneity tests and dispersibility tests. Data analysis was carried out by testing the physical quality of each formula compared to the quality standard of lotion preparations according to theory. From the research that has been done, it shows that the composition of the 4 formulas shows homogeneous results. The pH values of the formulas with extract concentrations of 5%, 10% and 5% and formulas without extracts were 5,8;5,3;5,1 and 6.6 (quality requirements 4,5 -6.6). Meanwhile, the pH distribution of the formula with 5%, 10% and 5% extract concentrations and the formula without extract was 5.2, respectively; 4.8; 4,4 and 5 (quality requirements 5-7). Based on the results obtained, it can be concluded that the formula with an extract concentration of 5% has the most physical stability that meets the requirements for the quality of lotion preparations.
Evaluasi Penggunaan Antibiotika Profilaksis Operasi Digestif Laparatomi Selly Septi Fandinata; Eziah Ika Lubada; Ilil Maidatuz Zulfa
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13496

Abstract

Laparotomy is a major operation and causes a lot of injuries, so the risk of infection of the laparotomy surgery wound is quite high. Surgical Site Infection (ILO) or Surgical Site Infection (ITP). Prevention of postoperative infection in patients with clean-contaminated surgery, and some clean operations with the use of prophylactic antibiotics. The purpose of this study was to evaluate the use of prophylactic antibiotics in patients with laparotomy surgery in a hospital in Surabaya. The research method is descriptive operational with retrospective data. The results of this study obtained as many as 160 patients aged 46-55 years at 20.6%, the sex of the respondents were dominated by male sex 66.3%, and the diagnosis of generalized peritonitis was 46.9%. The use of prophylactic antibiotics is class I cephalosporin antibiotics (cefazolin) with a dose of 1000-2000 mg, which is by the 2011 Ministry of Health guidelines.
Pengaruh Pemberian Ekstrak Kulit Pisang dan Kulit Nanas terhadap Kadar Kalium Tikus Putih Wistar Hiqbar Hiqbar; Hadi Kurniawan; Pratiwi Apridamayanti
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13633

Abstract

The waste of banana peels and pineapple peels in its utilization is still very lacking, even though it has the potential to be developed because they have high potassium as potassium intake in the body. The combination of banana peel extract and pineapple peel extract is expected to have a synergistic effect as a potassium supplement. The purpose of this study was to determine serum potassium levels of rats (Rattus norvegicus L.) Wistar with banana peel and pineapple peel extracts. Banana peel and pineapple peel were extracted using the infusion method. The test animals used male and female Wistar rats. The control group was given glucose and sucrose bases, the test group was given doses of 100, 400, and 1000 mg/KgBW of banana peel and pineapple peel extract with glucose and sucrose bases, and the control satellite group and satellite dose of 1000 mg/KgBW. The results of all groups showed normal levels of potassium in blood serum. Potassium levels between each group did not show a significant difference (p≥0.05) in male and female rats. Conclusion: administration of banana peel and pineapple peel extract did not affect the serum potassium level of Wistar rats.
Histopatologi Organ Pankreas Tikus DM tipe 2 yang diberi Ekstrak Etanol Daun Gedi Merah (Abelmoscus manihot L. Medik) Nuralifah Nuralifah; La Ode Muhammad Fitrawan; Parawansah Parawansah; Mesrawati Trisetya
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13566

Abstract

Gedi Merah leaf (Abelmoschus manihot L.Medik) is a tropical plant used by the community as a traditional medicine to reduce cholesterol, hypertension, and antidiabetic levels. Diabetes mellitus is a disorder of carbohydrate, protein, and fat metabolism due to a lack of the hormone insulin so that glucose in the blood increases which is characterized by changes in the histopathological structure of the pancreatic islets of Langerhans. The purpose of this study was to see the histopathological description of the pancreas in male white rats (Rattus norvegicus) Wistar strain model of type II diabetes mellitus by administering ethanol extract of red gedi leaves (Abelmoschus manihot L.Medik). Modeling of diabetes mellitus in experimental animals was carried out by administering a high-fat diet and intraperitoneal induction of streptozotocin 30 mg/kg. After modeling, male rats were grouped into 6 treatment groups, namely a normal control group, a positive control group, a negative control group, and a group that was given the ethanol extract of red gedi leaves at a dose of 75 mg/kg BW, 150 mg/kg BW 300 mg/kg BW. The results of the histopathological examination of the pancreas and the number of endocrine cells showed that the ethanolic extract of red gedi leaves (Abelmoschus manihot L.Medik) was effective in repairing pancreatic cells and regenerating endocrine cells in the islets of langerhans.
Identifikasi Kandungan Senyawa Antioksidan Ekstrak Daun Bidara (Ziziphus mauritiana Lamk.) Dengan Menggunakan Metode DPPH La Sakka; Rahmatullah Muin
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13518

Abstract

Bidara is a plant that is known to be rich in antioxidants and is a plant that can withstand extreme temperatures and is able to survive in a rather dry environment. Bidara leaves are included in the type of compound leaves where these compound leaves have branching stalks and on the stem branches there are leaf blades, on one stalk there are more than one leaf blade, a compound leaf is considered to come from a single leaf whose incision is so deep that the the leaves between the nicks are separate from each other and each is a separate little strand. The purpose of this study was to determine the level of antioxidants contained in bidara leaf extract (Ziziphus mauritiana Lamk) using the DPPH method. The method used is the DPPH method (2,2-diphenyl-1-picrylhydrazyl). This test consisted of 4 concentration treatments, namely, 50 ppm, 100 ppm, 150 ppm, and 200 ppm with each comparison of vitamin C with a concentration of 2 ppm, 4 ppm, 6 ppm and 8 ppm. By testing using Uv-Vis Spectrophotometry. The results of this study obtained a linear equation Y = 0.0005x + 0.4172, so the IC50 value is 119.84 (μg/ml), this means that the level of antioxidant activity of bidara leaf extract is moderate.
Efektivitas ekstrak etanol bayam merah (amaranthus tricolor l.) Terhadap glukosa darah Tikus putih ( rattus novergicus) jantan Yang dipapar dengan asap rokok suryanita suryanita; Ferna Indrayani; Muhammad Asri
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13507

Abstract

Research has been carried out on the effect of giving ethanol extract of red spinach (Amaranthus tricolor L.) on blood glucose of male white rats (Rattus novergicus) exposed to cigarette smoke for an interval of 15 days with the administration of ethanolic extract of red spinach. This study aims to determine the effect of ethanol extract on blood glucose levels of male white rats which were divided into 4 groups. Group I as a positive control that was not given any treatment, group II was given ethanolic extract of red spinach 200 mg/kg BW, group III was given ethanolic extract of red spinach 400 mg/kg BW, and group IV as a negative control was only given cigarette smoke exposure without any treatment. extract administration. From the research that has been done, the results of the decrease in blood glucose in group I is 63,3 mg/dl, group II is 98 mg/dl, group III is 116 mg/dl, and group IV is 155 mg/dl. Based on the results obtained, it can be concluded that the decrease in blood glucose caused The most effective is red spinach ethanol extract with a concentration of 200 mg/kg BW, which is 98 mg/dl.
Penggolongan Obat Berdasarkan Peresepan Obat Asma Di Instalasi Rawat Jalan RSUD Dr Agoesdjam Ketapang Defiga Kasrin; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13648

Abstract

Asthma was included in the top ten causes of morbidity and mortality in Indonesia. The priority of asthma treatment so far is to control symptoms. Therefore, the classification of drugs based on asthma drug prescribing is very necessary. This study aims to determine the characteristics and classes of drug prescribing in outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang in 2020. This research method was carried out in December 2021-January 2022 with a retrospective descriptive method, data obtained from medical record cards of outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang in 2020. The data obtained are presented in the form of percentages, average values and tables. The results showed that of the 61 outpatient asthma patient medical records analyzed by the percentage data, the majority of patients were women (59%) and at the age of 42-49 years (31%). The most widely prescribed drug group was beta-2 agonist (48%) with the most common dosage form being inhalers (51%) and the route of drug use was inhalation (51%). The conclusion is that the use of drugs in asthma patients in the outpatient installation of RSUD Dr. The majority of Agoesdjam Ketapang are women. The majority occurred at the age of 42-49 years, the most widely used drug class was the beta-2 agonist group with the inhaler dosage form and the inhalation route was the most widely used.

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