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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
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Articles 34 Documents
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Search results for , issue "Vol 4, No 3 (2022): Volume 4 Edisi 3 2022" : 34 Documents clear
Identifikasi Senyawa Metabolit Sekunder Daun Spigelia anthelmia L. dan Uji Aktifitas Antioksidan Menggunakan Metode DPPH (1,1-Diphenyl-2-Picrylhidrazy) Muhammad Taupik; A. Mu’thi Andy Suryadi; Jafar La Kilo; Wiwit Zuriati Uno; Samsul Bahri Badjeber
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15927

Abstract

Spigelia anthelmia is a type of weed plant that is classified as toxic and is included in the list of herb of medicine. The research aims to determine the secondary metabolite content of Spigelia anthelmia L. leaves extract and antioxidant activity test using the DPPH (1,1-Diphenyl-2-Picrylhydrazy) method. The research samples are extracted by applying the total maceration method with methanol as a solvent and followed by partition method using n-hexane, ethyl acetate, and methanol as solvents. The identification of flavonoid compounds content is performed by employing Thin Layer Chromatography method with methanol as eluent: n-hexane (1:4), ethyl acetate:n-hexane (4:1), ethyl acetate:n-hexane (4:1). Meanwhile, the antioxidant activity test is performed by employing UV-Vis Spectrophotometry method. The result of identification by thin layer chromatography using AlCl3 spray reagent, Lieberman Burchard. Dragendrof, and cerium sulfate, indicate that the Spigelia anthelmia L. leaves extract contains alkaloids, flavonoids, and terpenoids. In addition, the antioxidant activity test of Spigelia anthelmia L. leaves extract is carried out at wavelength of UV 516 nm with an absorbance value of 0,654 A. with a linear equation of y = 0,027 x – 42,83 with a correlation coefficient (R2) = 0,0983 and has the strongest IC50 at the methanol fraction for 7,69 µg/ml.
Evaluasi Perbandingan Sistem Rantai Dingin Penyimpanan Vaksin Maelana Eka Dewi; Iswandi Iswandi; meta kartika
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16485

Abstract

Vaccines are preparations of biological products that contain antigens or contain components of microorganisms that have been attenuated from genetic engineering. Defective vaccine quality can be caused by the time of the cold chain storage process that is not in procedure. This study aims to compare the vaccine cold chain system in the warehouse of the City Health Office and Salatiga City Health Center which is guided by the Indonesian Minister of Health Regulation Number 12 of 2017. This type of research uses a descriptive observational method. The data collected in the form of quantitative and qualitative. Collecting qualitative data obtained from interviews and observations. Qualitative data were obtained from vaccine storage data in 2021. The results of the study obtained that he cold chain compatibility system at the City Health Office and Salatiga City Health Center was in good category, with the percentage of the City Health Office 88.88%, Cebongan Health Center 77.77%, Mangunsari Health Center 70.37%, Kalicacing Health Center 85.18%, Tegalrejo Health Center 81.48%, Sidorejo Lor Health Center 81.48%, Sidorejo Kidul Health Center 77.77%. Supporting facilities for vaccine storage are in accordance with the guidelines of the Permenkes RI Nomor 12 tahun 2017, in good category. With the percentage of the City Health Office 99.64%, Cebongan Health Center 96.87%, Mangunsari Health Center 97.02%, Kalicacing Health Center 91.80%, Tegalrejo Health Center 94.11%, Sidorejo Lor Health Center 96.29%, Sidorejo Kidul Health Center 98,30%.
Analisis Penggunaan Kotak Pil (pill Box) Terhadap Kepatuhan Penggunaan Obat Pada Pasien Diabetes Melitus Tipe 2 Apriani Metya Pratiwi; Nurmainah Nurmainah; Mohammad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15643

Abstract

Diabetes Mellitus (DM) is a chronic disease that occurs when the body cannot produce enough insulin. Adherence is a major factor in determining the success of treatment. The use of pillboxes is a common method of reminding patients of their medication schedule. The problems found in the community are not compliant in taking drugs, especially type 2 DM patients. These factors are known to hinder the success of achieving optimal DM treatment. The purpose of this study was to determine the effect of using a pill box on medication adherence in type 2 DM patients using the Morisky Medication Adherence Scale (MMAS-8) questionnaire. This study uses an experimental method with a cross sectional study, the sampling technique used is the quota sampling technique. Data was collected by filling out a questionnaire using the MMAS-8 questionnaire. The population used was adult patients with DM who were outpatients at Sungai Raya Dalam Public Health Center. The data collection process is carried out through visits to the patient's home (home visit). Data analysis in this study used the SPSS application. The results of the measurement of the highest level of compliance were obedient (24%) and a significant value was obtained from the Paired Sample t-Test test, which was 0.000 (0.05) which showed that the pill box could improve patient compliance in taking medication. The pill box makes it easier for patients to set the time to take medicine.
Identification of Paracetamol in Jamu Using Thin Layer Chromatography Analysis Method Iga Yastiara; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15284

Abstract

Jamu is one of the Indonesian traditional medicine. Jamu is efficacious for health so it is widely consumed by the society. The high level of consumption causes trade competition from jamu industry in various regions, including in Pontianak City, West Kalimantan. However, several jamu industries in Pontianak have violated the law by adding medicinal chemicals to jamu. The most widely added medicinal chemical in jamu is paracetamol. Paracetamol which indicates as an analgesic-antipyretic can be harmful for health because it increases liver hepatotoxicity if consumed continuously.This study aims to identify paracetamol in herbal medicine. A total of 10 samples were obtained in Pontianak City, West Kalimantan by purchasing directly or from an online shop. This study used thin layer chromatography as an instrument of qualitative analysis. The results of the analysis using thin layer chromatography were Rf samples A, B, and G were 0.675, respectively; 0.6625; 0.6625 which is close to the standard Rf value for comparison of paracetamol, which is 0.675. Those three samples contained paracetamol because they had a different Rf value 0.05 from the standard Rf value.
Evaluasi Penggunaan Antibiotik pada Pasien Pediatri ISPA dengan Metode Gyssens Eva Najmah Novita; Ressi Susanti; Nurmainah Nurmainah
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15447

Abstract

Acute Respiratory Infection (ARI) is an upper or lower respiratory tract infection caused by a virus or bacteria. The high prevalence of ARI in Indonesian children can increase the risk of irrational use of antibiotics. This study aims to describe the types of antibiotics that are often used and analyze the rationality of antibiotics usage in pediatric ARI inpatient in Sultan Syarif Mohamad Alkadrie Public Hospital using the Gyssens method. This study is an observational study with a cross-sectional design. Data were collected retrospectively with consecutive sampling method. Data were analyzed using the Gyssens method based on therapeutic guidelines by IDAI, the Indonesian Ministry of Health, and WHO. The result showed that from 98 patients, the types of antibiotics were obtained as follows: third generation of cephalosporin group (66.16%), the penicillin group (19.23%), and the macrolide group (14.61%). Based on the results of the evaluation of antibiotics using the Gyssens method, the percentage of antibiotics usage that are in category 0 is 11,24%, category I (15,73%), category IIa (17,98%), category IIb (24,16%), category IIIa (0,56%), category IVa (15,73%), category IVc (1,69%), and category V (12,92%). It can be concluded that there is still irrational use of antibiotics in pediatric ARI inpatient in Sultan Syarif Mohamad Alkadrie Public Hospital in 2019-2020.
Aktivitas Penyembuhan Luka Sayatan Sediaan Salep Ekstrak Etanol Daun Patiwala (Lantana camara L.) Nuralifah Nuralifah; Nur illiyyin Akib; Rifa’atul Mahmudah; Fery Indradewi Armadany; Parawansah Parawansah; Indah Amalia Lestari
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16522

Abstract

Patiwala (Lantana camara L.) contains flavonoid compounds, tannins, and saponins which are efficacious as a wound healer. Research on activities test of the incision wound healing ointment preparations from patiwala leaf ethanol extract (Lantana camara L.) aims to know the wound healing activity of ointment slices of ethanol extract of patiwala leaves in male white rabbits, as well as knowing the potential irritation of ointment preparations from ethanol extract of patiwala leaves in humans. Phytochemical screening was done by the color testing reaction method. The ointment formulation was carried out by the smelting method using vaseline album and cera alba base with a concentration of 4% extract. The incision wound healing activity test was performed with the Morton method using a rabbit test animal. The irritation test was carried out using the patch test method on 12 panelists. Phytochemical screening results prove that the patiwala leaves contain flavonoid compounds, tannins, and saponins which are efficacious as wound healers. The best activity test results on wound healing in rabbits are incision ointment of patiwala ethanol extract at 4% concentration with 100% healing time for 10,3 days. The results of the irritation test showed that the ointment extract of patiwala leaves proved to be non-irritating so it was safe to use. It was concluded that the ethanol extract of 4% patiwala leaves had activity as a wound healing wound.
Analisis Hubungan Tingkat Pengetahuan terhadap Perilaku Swamedikasi Batuk selama Masa Pandemi Covid-19 Lusi Ariska Triani; Hariyanto IH; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15669

Abstract

The Covid-19 pandemic gave an impact on the limitation of health services in health facilities, causing people to choose self-medication as their treatment method. The purpose of this study is to determine the level of knowledge and self-medication behavior of cough symptoms in Rasau Jaya District and the correlation between those two variables during the Covid-19 pandemic. Cross-sectional design with purposive sampling technique was used as a research method for 75 respondents and questionnaires were used as a measuring tool. Data processing was carried out using SPSS statistical tests. We found that none of the respondents had low knowledge levels with 71 respondents (94,7%) having a good level of knowledge and 4 respondents (5,3%) having sufficient levels. This result are in line with self-medication behavior showed that 73 respondents (97,3%) have a good level of behavior at doing self-medication of cough and 2 respondents (2,7%) have deficient levels. The majority people in Rasau Jaya District have a good level of knowledge and self-medication behavior and we found that there is a correlation between those two variables.
Pengaruh Kelengkapan Resep Terhadap Prescribing Error Obat Golongan Benzodiazepin di Tiga Apotek Kota Bandung Nuke Fendiana; Meta Kartika Untari; Ika Purwidyaningrum
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15784

Abstract

Reviewing prescriptions, especially psychotropic drugs, is one part of clinical pharmacy services carried out by pharmacists to analyze drug-related problems and avoid medication errors, especially at the prescribing stage. The purpose of this study was to determine the suitability of prescribing services for benzodiazepine drugs with the Regulation of the Minister of Health of the Republic of Indonesia and to find the effect of administrative, pharmaceutical and clinical completeness on the incidence of prescribing errors in prescribing benzodiazepine drugs in three pharmacies in Bandung City in 2021. This research method is a descriptive research conducted retrospectively where the data were prescriptions for January 2021-December 2021 at three Bandung City Pharmacies. The analysis was carried out by grouping each data variable from administrative, pharmaceutical and clinical aspects which were then processed using Microsoft Excel and SPSS programs. The results showed that the completeness of prescription psychotropic benzodiazepines still did not meet the requirements of the Regulation of the Minister of Health of the Republic of Indonesia No. 73 of 2016 where the total incidence of prescribing errors in the prescription section was 11.66%, subscription was 16.58% and pro was 100. %, there is a significant relationship with a correlation coefficient value of 0.269 which means that there is a sufficient influence between doctor qualifications and the incidence of prescribing errors and there is a relationship between the completeness of administrative, pharmaceutical and clinical prescriptions with the incidence of prescribing errors which is significant with a probability value of 0.000 and a correlation coefficient value of 0.749 which means strong influence. Based on the data above, it can be concluded that the completeness of prescriptions in the Administrative, Pharmaceutical and Clinical categories is still not complete in accordance with the Regulation of the Minister of Health No. 73 of 2016.
Studi Rasionalitas Pemakaian Obat Antihipertensi Pada Kasus Pasien Rawat Jalan Teti Sutriati Tuloli; Endah Nurrohwinta Djuwarno; Faramita Hiola; Fika Nuzul Ramadhani; Divia Handayani Mudjidu
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16018

Abstract

Hypertension is a disease that happens when the systolic and diastolic blood pressure is higher than 140/90 mmHg. This study aimed to identify the use of an anti-hypertension drug on outpatients at Kota Timur Community Health Center in Gorontalo, with medical records of hypertension patients from January to June 2021 as the data source. Employing the univariate analysis method, this study obtained patients' data to be recapitulated into the primary table to be descriptively analyzed. The findings in gender frequency revealed that 36 male respondents attained 53.3% of percentage and 81 female respondents attained 46.6% of percentage, while the respondent age frequency that is mostly 46-65 years old numbered 83 patients (71%), 26-45 years old numbered 22 patients (18.80%), and 65 years old numbered 12 patients (10.25%). Based on drug use from January to June 2021, the most consumed drug is Amlodipine, with 70 consumption (60%). Further, based on diseases in other categories from January to June 2021, the highest diagnosis on hypertension patients is 71 times of hypertension (60%), while the systolic and diastolic pressure category from January to June 2021 revealed that the highest blood pressure of the stage 1hypertension patients is 63 times (54%).
Isolasi dan Karakterisasi Jamur Endofit Lamun (Thalassia hemprichii) Dari Kawasan Teluk Tomini Mahdalena Sy. Pakaya; Wiwit Zuriati Uno; Dizky Ramadani Putri Papeo; Dewi Rahmawaty Moo
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15852

Abstract

Endophytic fungi live in their host tissues. Endophytic fungi can produce compounds similar to their hosts as well. In this case, the use of endophytic fungi can reduce the exploitation of seagrass (Thalassia hemprichii) populations in Tomini Bay. This study aims to isolate and determine the characteristics of the endophytic fungus of seagrass (Thalassia hemprichii) from the Tomini Bay area. The test method used is the isolation and characterization macroscopically and microscopically. The results of the isolation obtained two isolates of endophytic fungi coded J1 and J2 with different characteristics. The isolate code J1 had microscopic characteristics of a yeast-like shape, while the isolate code J2 had the characteristic of non-septate hyphae.

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