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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
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Articles 34 Documents
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Search results for , issue "Vol 4, No 3 (2022): Volume 4 Edisi 3 2022" : 34 Documents clear
Evaluasi Penyaluran Vaksin Sesuai Standar CDOB (Cara Distribusi Obat yang Baik) Kintan Fahra Ningrum; Iswandi Iswandi; Meta Kartika Untari
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15644

Abstract

Vaccines are biological products made using germs and then weekened. According to existing studies, 75% of vaccines in Indonesia are exposed to freezing temperatures during the distribution process, as a result, vaccines cannot be used anymore. The City Health Office has responsibility for the distribution of vaccines, especially in health centers, which must be evenly distributed and given regularly at the right time. The purpose of this study is the distribution of cold chain vaccines from the City Health Office to Salatiga Health Centers using the 2020 CDOB regulatory guidelines. This study uses an observational method that has a descriptive nature and evaluation using data collection techniques by interviewing with pharmacists or vaccine managers. The data will be based on the analysis of the result of data collection using an interview sheet, and the results will be stated with a percentation. The results of the study indicate that the distribution guidelines for the rantai dingin vaccine distribution system from the Health Office to the Salatiga City Health Center using the 2020 CDOB have a good category with a percentage of 72,72% and 84,21%. Then, there was a discrepancy in the distribution carried out by the Health Service to the Salatiga City Health Center but no deviation occurred, the vaccine distributed was not damaged or expired. Factors that may occur due to discrepancies are the lack of Human Resources (HR) for vaccine managers and vaccine warehouses that have not been maximized.
Standarisasi Mutu Tanaman Herbal Aur-Aur (Commelina longifolia L.) dan Tanaman Bungango (Flueggea virosa Royle) Andi Makkulawu; A. Mu’thi Andy Suryadi; Muhammad Taupik; Mahdalena Sy. Pakaya; Ariani. H Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16044

Abstract

In the developing materials for traditional medicines, it is necessary to standardize the quality of plant materials. Tuhus, quality, stability, and safety. This study aims to determine several standardization parameters and determine the flavonoid content of the 70% ethanol fraction of aur-aur leaves (Commelina longifolia L.) and bungango leaves (Flueggea virosa Royle) to ensure that the fractions have quality and measurable parameter values. The fraction was standardized with two parameters, thus specific and non-specific, and flavonoid content test using UV-Vis spectrophotometry method. The results of phytochemical screening, the fraction containing flavonoid compounds is 70% ethanol fraction. Standardization of specific parameters showed the organoleptic results of both aur-aur (Commelina longifolia L.) and bungango (Flueggea virosa Royle) leaf fractions in the form of a semi-solid viscous fraction, black in color, and characteristic odor. The content of water soluble extract and ethanol soluble extract of aur-aur (Commelina longifolia L.) leaf fraction were 22.84%, ethanol soluble extract 25.03%, while the fraction of Bungango (Flueggea virosa Royle) leaf was 30.70%. and 27.31%. Standardization of non-specific parameters showed the results of water content 21.40%, total ash content 8.92%, acid insoluble ash content 0.043%, drying shrinkage 10.48%. The results of non-specific standardization of bungango leaves (Flueggea virosa Royle) showed a moisture content of 14.45%, a total ash content of 9.62%, an acid insoluble ash content of 1.31%, a drying shrinkage of 10.64%. The results for the analysis of the flavonoid content of the 70% ethanol fraction of aur-aur leaves and bungango leaves were carried out at a wavelength of 438.36 nm. The total flavonoid content was calculated by the standard linear equation of quercetin, namely y= 0.0648x + (-0.0232) with a correlation coefficient (r2) = 0.9948 with the total flavonoid content of aur-aur leaf and bungango leaf each of 3.57. % and 9.578%.
Identify the Rhodamin B on lipsticks in the market Using Thin Layer Chromatography (TLC) Method Nurul Fajriani; Hadi Kurniawan; Fajar Nugraha
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15392

Abstract

Rhodamine B is a synthetic dye used as a dye for paper and textiles. This dyeis prohibited from being used in cosmetics including lipstick because it can cause skin irritation, irritation to the digestive tract, poisoning, and can cause cancer. The research aims to identify Rhodamine B contained in lipstick circulating in the market area of Pontianak City. Sampling was carried out using purposive sampling technique, obtained 7 samples of lipstick circulating in the market area of Pontianak City. The analysis of Rhodamine B in this lipstick was carried out by Thin Layer Chromatography method using silica gel plate GF 254 and the mobile phase is a mixture of n-butanol, ethyl acetate, and ammonia in a ratio (10:4:5). The results of this study obtained 2 positive samples containing Rhodamine B, namely samples A and E. The Rf values in the samples were 0.75 and 0.675, which were close to the Rf value for the comparison of Rhodamine B, which was 0.7375. The identification results showed that from 7 lipstick samples there were 2 samples positive for Rhodamine B dye. 
Characterization of The Process of Making Golden Sea Cucumber (Stichopus hermanii) Simplicia Sumaryani Sumaryani; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15730

Abstract

haracterization is the first step to ensuring uniformity of drug quality. Golden sea cucumber (Stichopus hermanii) is one of the natural ingredients that has efficacy as a wound-healing drug. This study aims to determine the characterization of the process of making golden sea cucumber Simplicia originating from Pelapis Island, Kayong Utara Regency, as raw materials for wound healing drug preparations. Simplicia was characterized biologically including morphology and habitat, physically including organoleptic, moisture content, ash content, and acid insoluble ash content, and chemically including phytochemical screening and protein content. Simplicia making process consists of sample collecting, wet sorting, washing, boiling, smoking, first drying, chopping, and second drying, dry sorting, packaging, and storage.% yield obtained is 8,43%. The results of the characterization were that fresh golden sea cucumbers had a yellow body, long of 31 cm, bodyweight of 1.3 kg, body thickness of 5 cm, and live in rock and coral areas with a sea depth of about 10-15 meters. Simplicia are brownish yellow, the distinctive smell of sea cucumbers, salty taste, and thin slices. The water content, ash content, acid insoluble ash content, and protein of Simplicia were 9.8%, 13.77%, 0.20%, and 36.1%, respectively. The outcome of phytochemical screening showed that Simplicia qualitatively contained alkaloids, saponins, and triterpenoids.
Analysis of Hydroquinone Content in Whitening Cream by Spectrophotometry UV-Vis Method Efprio Nensa Kurniawan; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15285

Abstract

Hydroquinone is an ingredient that is often added in whitening creams with the aim of whitening the skin. According to BPOM Regulation No.23 of 2019, hydroquinone has been banned from its use as a bleach or lightener in cosmetics. The use of hydroquinone can only be used for nails with a level of 0.02%, as well as hair dye oxidizers with a maximum level of 0.3%. The mechanism of hydroquinone in whitening the skin is the toxic effect of hydroquinone on melanocytes, and through inhibition of the process of melanin formation. This study aims to identify and determine the levels of hydroquinone contained in whitening creams circulating in Pontianak City. The research method used in this study is descriptive non-experimental, where as many as 10 samples of whitening cream circulating in Pontianak City were obtained using purposive sampling techniques. Identification of hydroquinone is carried out qualitatively using FeCl3 1% reagent, and benedict reagent. Determination of hydroquinone levels in the sample is done quantitatively using a UV-Vis spectrophotometer. Based on the calculation of validation parameters, the equation y = 0.0251x – 0.0029, linearity value with relation coefficient (r) of 0.9999, %recovery of 100.15%, precision with a value of %RSD of 0.4899%, LOD of 0.2742 ppm and LOQ of 0.9140 ppm. Based on the results obtained, as many as 8 samples of positive whitening creams contained hydroquinone with a sample level of A of 3.1630%; sample B of 2.7322%; C sample of 2.5335%; sample D of 2.3216%; G sample is 2.5118%; H sample of 3.3171%; sample I was 2.4409 and sample J was 0.5571%.
Evaluasi Pengobatan Radioterapi Pada Pasien Kanker Herlinda Mahdania Harun; Nurul Jannah; Idawati Idawati; Zul Fikar Ahmad
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15794

Abstract

Cancer is one of the leading causes of death in the world. Riskesdas data in 2018, that there is an increase in the prevalence of cancer in Indonesia every year and treatment with radiation/irradiation. The purpose of this study was to describe the characteristics (gender, age, education level, occupation), type of cancer, and duration of treatment as well as side effects obtained by cancer patients during or after radiotherapy treatment. The location of the research was carried out at the RSI. Faisal Makassar. This type of research is quantitative descriptive with consecutive sampling. Data was collected using medical records of cancer patients who underwent radiotherapy and then telephone interviews based on questionnaires. Data analysis in this study is descriptive quantitative univariate analysis to describe the distribution of each research variable. Research results obtained 49 cancer patients who underwent radiotherapy, the characteristics of the most respondents were the 46-52 year age group by 26.5% (13 people), female 71.4% (35 people), the last high school education was 44,9% (22 people), work as a housewife by 44.9% (22 people), the most type of cancer diagnosis is cervical cancer by 28.6% (14 people), the length of treatment received for 3 months is 40 times radiation treatment/therapy, and the perceived side effects of radiotherapy were weakness, pain, and dermatitis in the radiation area.
Formulasi Sediaan Sabun Cair Dari Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Andi Nurpati Panaungi; Hasma Hasma
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16483

Abstract

Cherry leaves (Muntingia calabura L.) is a plant that has many medicinal properties. One part of the plant that is widely used is the leaf which contains flavonoid compounds, saponins and tannins found in cherry leaves so that it has strong antioxidant activity which can be efficacious as skin lightening and antiseptic. This study aims to formulate liquid soap ethanol extract of cherry leaves (Muntingia calabura L.). This type of research was carried out in an experimental laboratory using the maceration method to produce a thick extract from cherry leaves. There were 3 formulas for liquid soap with different extract concentrations, namely FI (3%), FII (6%), and FIII (9%). Tests for liquid soap preparations of cherry leaves extract include organoleptic tests (shape, smell, color), homogeneity test, pH test, foam height test, and water content test. From the results of research conducted on organoleptic tests, FI(3%) has has a liquid form, brown color and a distinctive aroma. and FIII(9%) has a slightly thick liquid form, dark brown color, and a distinctive aroma. In the homogeneity test on all formulas get homogeneous results. In the pH test FI(3%) with a pH of 8, FII(6%) and FIII(9%) with a pH of 9. In the FI(3%) foam height test with a foam height of 8.5 cm, FII(6%) with a foam height 7.7 cm, FIII(9%) with foam height 7.1 cm. on the water content test FI(3%) with a water content of 56.25%, FII(6%) with a water content of 53.75%, FIII(9%) with a water content of 48.00%. So it can be concluded that the liquid soap formulations FI(3%), FII(6%), and FIII(9%) meet the requirements set by SNI in every test of liquid soap preparations. So that cherry leaf extract can be formulated into liquid soap with extract concentrations of 3%, 6% and 9%.
Rasionalitas Penggunaan Obat Antituberkulosis Pada Pasien Tuberkulosis Paru Rawat Jalan Jeshy Milantika; Muhammad Akib Yuswar; Nera Umilia Purwanti
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15602

Abstract

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Tuberculosis is easily transmitted through the air or from a source of transmission, namely patients with positive AFB (acid-fast bacilli) tuberculosis when coughing or sneezing. The purpose of this study was to evaluate the rationale for using OAT in pulmonary TB patients and examine the relationship between gender, age, chronic comorbidities and duration of treatment with treatment outcomes. The method used in this research is descriptive observational method with a cross sectional design. The sample used was 60 people. Data collection was carried out retrospectively using medical record data and patient prescriptions in the outpatient installation of RSUD dr. Soedarso Pontianak for the period January-December 2020. The results showed that the rationality of using antituberculosis drugs in pulmonary TB patients based on the right indications was obtained by 100%, the right patient 100%, the right drug 96.7%, the right dose 85%, and the right time giving 95%.
Isolasi dan Uji Aktivitas Antiinflamasi Ekstrak Daun Andong (Cordyline fructicosa (L) A.Chev) Endah Nurrohwinta Djuwarno; Hamsidar Hasan; Mahdalena Sy. Pakaya; Faramita Hiola; Dewa Ayu Puspita
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15740

Abstract

Andong (Cordyline fructicosa (L) A. Chev) is used as traditional medicine, the use of this traditional medicine is related to the content of secondary metabolites contained in the andong plant. Empirically people use this plant as an antioxidant, the compound that acts as an antoixidant is related to antiinflamasi. The purpose of this study was to isolate secondary metabolites from the extracts of N-Hexane, Ethyl Acetate, and Methanol from Andong (Cordyline fructicosa (L) A. Chev) leaves and to determine the anti-inflamatory effect of the isolated secondary metabolites of Andong (Cordyline fructicosa (L) A. Chev) leaves through in vitro with red blood cell stabilization method. Several methods are used in the isolation of these compounds, namely extraction, identification of compound, fractionation of KCV and KKG, KLT,KLTP, and characterizationof compounds using UV-VIS spectrophotometry and FTIR. The results of UV-VIS characterization show a maximum wavelength of 434 nm, and the results of  FTIR characterization indicate the presence of a functional groups namely O-H (Hidroxyl) at a wave number of 3448,72 cm-1, C-H (Aliphatic) at a wave number of 2954,95 cm-1, 2920,23 cm-1, and 2852,72 cm-1, aliphatic compounds are supported by the presence of CH2 and CH3 at wave number of 1463,97 cm-1 and 1379,10 cm-1, C=O (conjugated carbonyl) at wave number of 1721,79 cm-1, C=C at wave number of 1633,71 cm-1, C-O at wave number of 1294,24 cm-1. So it is very likely that the compounds in Andong leaves isolate are flavonoid compounds. Furthermore, the activity of results of the isolation is tested where the isolate whit a concentration of 100 ppm signifies the highest anti-inflamatory activity, with the ability to stabilize red blood cell membranes of 80,142 %.
Analisis Efektivitas Biaya Penggunaan Kortikosteroid Inhalasi Pada Pasien Asma Rawat Jalan di Rumah Sakit Shinta Nia Putri; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15452

Abstract

West Kalimantan is in the 6th highest order whose prevalence of asthma exceeds the national rate of 2.4% in 2018. Asthma therapy with inhaled corticosteroids that take a long time needs to be cost-effective so as not to increase the patient's immediate medical costs.  This study aims to determine the cost-effectiveness of using inhaled corticosteroids given to outpatients at Dr. Agoesdjam Hospital, Ketapang Regency. The study was conducted in a cross-sectional retrospective manner by taking data on patient medical records for the January-December 2020 period.  The sampling technique is carried out by purposive sampling. The pharmacoeconomic analysis carried out is Cost Effectiveness Analysis (CEA). The Average Cost Effectiveness Analysis (ACER) and Incremental Cost Effectiveness Analysis (ICER) methods  are used to analyze the most cost-effective inhaled corticosteroids. The results of the study were obtained with the characteristics of the study subjects based on gender the number of male patients n=23 (39%) and female n=36 (61%). The conclution of this research are the percentage of effectiveness of the use of inhaled corticosteroids at Dr. Agoesdjam Hospital, Ketapang Regency in 2020 is 33-100% and the most effective inhaled corticosteroids are flutiase combinations; Brotec; Combivent with an effectiveness of 100% with an ACER value of Rp. 731.45.

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