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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
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Articles 2 Documents
 1 
Search results for , issue "Vol 7, No 2 (2025): Volume 7 Edisi 2 2025" : 2 Documents clear
The Impact of Nutrition Education Intervention on Parental Knowledge to Prevent Child Stunting Laksmi Puspa Sari, Gusti Ayu Putu; Ari Kusuma Yana, I Gusti Agung; Irawati Wibowo, Yosi
Journal Syifa Sciences and Clinical Research Vol 7, No 2 (2025): Volume 7 Edisi 2 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i2.30531

Abstract

Stunting remains a significant health problem among children worldwide. Stunting has an impact on children's physical and cognitive development; if it is not addressed in the earliest stage, it can lead to decreased national productivity and economic growth. Whilst parents play a crucial role in preventing stunting in children, ensuring they have adequate knowledge is essential. This study aimed to determine the effect of educational intervention on the level of knowledge among parents in preventing child stunting. This is a pre-experimental study using a pretest and posttest design. This study involved a sample of 93 respondent in an area in the Bali area. The educational intervention involving a single session of health education focused on increasing knowledge about childhood stunting. Pre-test dan post-test was conducted before and after the intervention, and the results were categorized into good, simply and less. Pre-test and post-test data was analysed using a paired t-test. The results showed a significant increase in the percentage of parents with good knowledge from 11.8% in the pre-test to 30.1% in the post-test (p-value 0.001). This finding showed the effectiveness of educational interventions to enhance parental knowledge, which might increase their participation in preventing the risk of child stunting.
In Silico Study of Acmella uliginosa Leaf Compounds Interaction with Human Glucosidase Marlina Kurnia, Nia
Journal Syifa Sciences and Clinical Research Vol 7, No 2 (2025): Volume 7 Edisi 2 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i2.30890

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or action. Glucokinase (GK) plays a crucial role in glucose homeostasis and is considered a promising therapeutic target for DM treatment. This study aims to evaluate the in silico interaction between the bioactive compound N-(2-phenylethyl)(2E,6Z,8E)-decatrienamide from Acmella uliginosa (Sw.) and the human GK crystal structure (PDB ID: 1V4S) using Molegro Virtual Docker software. Molecular docking analysis revealed that N-(2-phenylethyl)(2E,6Z,8E)-decatrienamide exhibits a high binding affinity to GK. Physicochemical and pharmacokinetic predictions using pkCSM indicate that this compound has a favorable pharmacokinetic profile, including high intestinal absorption and the ability to cross the blood-brain barrier. These findings suggest that N-(2-phenylethyl)(2E,6Z,8E)-decatrienamide is a promising candidate for the development of natural product-derived antidiabetic drugs. However, further in vitro and in vivo studies are required to validate its biological activity and safety.

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