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INDONESIA
Indonesian Journal of Kidney and Hypertension
Published by Indonesian Society of Nephrology (InaSN)
ISSN : 30470765     EISSN : 26544253     DOI : https://doi.org/10.32867/inakidney
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
The primary mission of this journal is to serve as a conduit for the dissemination of both clinical and foundational research pertinent to the expansive domains of nephrology and hypertension. Spanning a diverse array of topics, the journal delves into multifaceted areas including but not limited to chronic kidney disease, electrolyte and pH imbalances, hyperparathyroidism, CKD-MBD (chronic kidney disease-mineral and bone disorder), anemia, acute kidney injury, renal replacement therapy encompassing both dialysis and transplantation modalities, hypertension, onconephrology, nephrotic and nephritic syndromes, as well as glomerulonephritis and various other glomerulopathies. Through comprehensive coverage of these multifaceted subjects, the journal aims to offer a holistic understanding of the intricate dynamics within the realms of nephrology and hypertension, thereby fostering advancements in clinical practice, research methodologies, and therapeutic interventions.
Arjuna Subject : Kedokteran - Nephrology
Articles 7 Documents
 1 
Search results for , issue "Vol 1 No 3 (2024): Volume 1 No. 3, December 2024" : 7 Documents clear
The Determinants of Detrimental Changes in Pulse Pressure During Maintenance Hemodialysis Treatments Ratna Damayanti; Iri Kuswadi; Raden Heru Prasanto; Metalia Puspitasari; Yulia Wardhani; Danny Pratama Kuswadi
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.128

Abstract

Background: Studies indicate that large fluctuations in pulse pressure during hemodialysis are associated with cardiovascular events, cardiovascular mortality, and all-cause mortality. Objective: We investigated the determinants of detrimental changes in pulse pressure (ΔPP) during hemodialysis. Methods: This prospective, observational cohort study was conducted from 1 to 30 April 2023 at Dr. Sardjito Hospital Yogyakarta, involving maintenance hemodialysis patients for ≥ 6 months. Patients were categorized into group 1 (detrimental ΔPP, ΔPP >5 mmHg or <−25 mmHg) and group 2 (stable ΔPP, −25 to 5 mmHg). Mann-Whitney, independent-t, chi-square, Fisher exact tests, and logistic regression were applied to evaluate associations between ΔPP groups and clinical variables. Results: This study involved 136 patients, 75 males (55.1%) with a mean age of 52 (18-87). The most common comorbid was hypertension, present in 85 patients (62.5%). The mean hemodialysis vintage of patients was 47.2 (6.5-330.7) months. We found significant difference between group in post-dialysis systolic blood pressure (SBP) (p=0.003), pre-dialysis diastolic blood pressure (DBP) (p=0.015), post-dialysis DBP (p=0.007), ultrafiltration (p=0.041), pre-dialysis mean-arterial-pressure (MAP) (p=0.013), post-dialysis MAP (p=0.002), and alpha-blocker treatment (p=0.037). Multivariate logistic regression analysis shows a significant association between groups of ΔPP with pre-dialysis DBP (p=0.035; OR=1.153; OR=Exp(10xℬ) =4.137) and post-dialysis SBP (p=0.007; OR=1.052; OR=Exp(10xℬ) =1.6487). Conclusion: Our study demonstrates that group 1, with detrimental changes in pulse pressure during hemodialysis, was found to have higher post-dialysis DBP, pre-dialysis DBP, post-dialysis SBP, pre-dialysis MAP, post-dialysis MAP, alpha-blocker treatment, and ultrafiltration, with significant association with post-dialysis SBP and pre-dialysis DBP.
Acute Kidney Injury with Characteristics of Rapidly Progressive Glomerulonephritis Due to Suspected IgA Nephropathy: A Case Report Sandra Yuliana Andini Putri; Nadhila Aditiyaputri; Amanukarti Resi Oetomo
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.141

Abstract

Acute kidney damage (AKI) in glomerular disease is typically characterized by rapidly progressive glomerulonephritis (RPGN). RPGN in IgA nephropathy is uncommon, occurring in less than 10% of patients. RPGN presents diagnostic issues in resource-limited settings. A 34-year-old male patient had acute kidney injury with RPGN characteristics based on clinical symptoms of hypertension, pitting edema, anuria, and hematuria after an upper respiratory tract infection, as well as laboratory findings of proteinuria, persistent microscopic hematuria, and positive erythrocyte casts. Serum creatinine levels rose sharply. Corticosteroids, antihypertensives, and hemodialysis resulted in clinical improvement and fast kidney function recovery. Due to limited resources, no kidney biopsy was conducted. This case provides a diagnostic approach to RPGN in IgA nephropathy in resource-limited settings, along with comprehensive therapy.
Observational Study on How the Frequency of Dialyzer Reuse Impacts Hemodialysis Effectiveness Ramadi Satryo Wicaksono; Atma Gunawan; Nur Samsu; Achmad Rifai
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.152

Abstract

Background: The increasing practice of dialyzer reuse in hemodialysis raises critical concerns regarding its impact on efficacy, infection risks, and essential metrics such as Urea Reduction Ratio (URR) and Kt/V values. Addressing these concerns is paramount to establishing safe and optimal reuse limits through comprehensive performance assessments. Objective: To evaluate the feasibility of dialyzer reuse by assessing Kt/V and URR measurements. Methods: A prospective cohort study was conducted at RSUD Dr. Saiful Anwar's Hemodialysis Unit from November 2021 to January 2022. Data collection employed a standardized pilot form designed to collate Kt/V and URR data from all participants. Statistical analyses included repeated measures ANOVA to detect temporal changes in average Kt/V and URR, alongside Spearman correlation analysis to explore variable relationships. Results: The study encompassed 15 participants, revealing a statistically significant decline in both Kt/V and URR values across each reuse group (p < 0.05). Specifically, each subsequent reuse of the dialyzer corresponded to a decrement of 0.0469 units in Kt/V and 1.003 units in URR. Notably, by the 7th reuse, hemodialysis adequacy remained satisfactory, achieving an average Kt/V of 1.61. Furthermore, the study indicated that even up to 11 reuses could achieve a Kt/V > 1.4. Similarly, the average URR value for the 7th reuse was 70.207%, with the potential to maintain URR > 65% even after up to 13 reuses. Conclusion: This study unequivocally affirms that hemodialysis adequacy remains satisfactory up to the 7th reuse of dialyzers, despite observed declines in Kt/V and URR values over successive reuses.
Characteristics and Clinical Outcomes of COVID-19 in ESRD Patients Undergoing Hemodialysis in Ngudi Waluyo Wlingi General Hospital in 2020-2022 Fajar Hadi Wijayanto; Aleyda Zahratunany Insanitaqwa; Syarifiyana Mawaddah
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.156

Abstract

Background: The coronavirus disease (COVID-19) pandemic is a major threat to global health care. Comorbidities, including end-stage renal disease (ESRD), are related to an increased risk of severe infection and mortality. Objective: To assess determinants related to the clinical outcomes of COVID-19 in ESRD patients undergoing hemodialysis in Ngudi Waluyo Wlingi General Hospital in 2020-2022. Methods: This study included ESRD patients undergoing maintenance hemodialysis who were hospitalized at Ngudi Waluyo Wlingi General Hospital due to COVID-19 from May 2020 to February 2022. Clinical characteristics were investigated in relation to the severity and survival status. Results: A total of 26 patients (46.15% male) with a mean age of 52.27±13.65 years met the inclusion criteria. Of these, 42.3% had a mild infection, 23% had a moderate infection, 30.77% had a severe infection, and 3.8% had a critical infection. The mortality rate was 23.08%, with a mean length of stay of 15.19±7 days. Age, oxygen saturation, respiratory rate upon admission, lymphocyte and neutrophil levels, and neutrophil-to-lymphocyte ratio were significantly associated with COVID-19 severity. Length of stay was statistically influenced by respiratory rate upon admission. The mortality rate was correlated with the dialysis vintage, levels of hemoglobin, leukocytes, platelets, neutrophils, neutrophil-to-lymphocyte ratio, serum urea, serum creatinine, eGFR, and length of stay. Conclusion: COVID-19 in ESRD patients undergoing hemodialysis were more likely to have a poor prognosis. Identifying determinants is crucial for reducing morbidity and mortality.
Association Between Fluid Administration and Hemoglobin Changes During Perioperative Kidney Transplantation Arundina Sanyoto; I Gde Raka Widiana; Gede Wira Mahadita; Yenny Kandarini; Nyoman Paramita Ayu; I Gusti Ngurah Agung Tresna Erawan
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.157

Abstract

Background: Chronic Kidney Disease (CKD) is a leading cause of mortality worldwide, particularly in Indonesia, so it requires effective treatment options like kidney transplantation. Optimal fluid therapy during the perioperative period is important for stable hemodynamics and graft function. However, guidelines for fluid administration remain lacking. Objective: This study investigates the association between fluid therapy and changes in hemoglobin levels in patients undergoing renal transplantation. Methods: A retrospective observational cross-sectional study was conducted at RSUP Prof. DR. I.G.N.G. Ngoerah Denpasar from January 2016 to August 2024. Data were collected from medical records of patients who underwent kidney transplantation, excluding those with incomplete data. Key variables included daily fluid intake and hemoglobin levels. The coefficient of variance was calculated and continued with correlation analyses utilizing Pearson correlation and linear regression to assess relationships between fluid administration and hemoglobin changes. Results: Of 28 patients, 10 met inclusion criteria, consisting of 4 males and 6 females. Analysis showed a strong correlation between the variance of fluid intake and the variance of hemoglobin levels (R = 0.86; R² = 0.74; P < 0.001). Conclusion: This study demonstrates a significant relationship between post-operative variance of fluid administration and variance of hemoglobin levels following kidney transplantation. It may have an impact on the management of post-operative reduction in hemoglobin levels.
Pathogenesis of Immune-Mediated Glomerulonephritis Nur Samsu
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.158

Abstract

Most forms of glomerulonephritis (GN) are characterized by a pathogenic immune response, which is mediated by the action of various immune system elements, both innate and adaptive. What is clear is that the immunopathogenesis of GN is very broad and complex. Deposits of immune complexes in the glomeruli activate complement and glomerular injury due to the involvement of circulating inflammatory cells and glomerular intrinsic cells, ultimately resulting in a wide variety of clinical manifestations, which depend in part on the location and immunopathology of the patient, including genetic and environmental factors, from asymptomatic to rapidly progressive GN. Most of the treatment strategies for GN are non-specific, consisting of corticosteroids and cytotoxic agents. Thus, an advanced understanding of GN immunopathogenesis may offer many opportunities for future therapeutic interventions on an individual basis. To further facilitate understanding of the pathogenesis of GN, the author also includes a graphical abstract.
Should All Patients with Nephrotic Syndrome Undergo a Renal Biopsy? Nur Samsu
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.160

Abstract

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