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Heri Setiyo Bekti
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ejournalskalahusada@gmail.com
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Jalan Sanitasi No.1 Sidakarya 80224 Denpasar, Bali - Indonesia
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INDONESIA
JURNAL SKALA HUSADA: THE JOURNAL OF HEALTH
Published by Politeknik Kesehatan Kemenkes Denpasar
ISSN : 1693931X     EISSN : 25803700     DOI : https://doi.org/10.33992/jsh:tjoh
Core Subject : Health,
Dentistry Nursing Public Health
Jurnal Skala Husada merupakan media publikasi karya ilmiah para dosen di lingkungan Politeknik Kesehatan yang ada di Indonesia, khususnya karya ilmiah di bidang teknologi kesehatan. Jurnal Skala Husada terbit setiap 6 bulan, atau terbit 2 kali dalam setahun.
Arjuna Subject : Profesi Kesehatan - Teknologi Laboratorium Medis
Articles 6 Documents
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Search results for , issue "Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health" : 6 Documents clear
UJI AKTIVITAS ANTIBAKTERI Staphylococcus aureus BERDASARKAN PERBEDAAN JENIS PELARUT EKSTRAK BIJI BUAH PEPAYA (Carica papaya L.) Lisa Anjani, Ni Putu; Suyasa, I Nyoman Gede; Habibah, Nur; Purna, I Nyoman
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.3946

Abstract

Staphylococcus aureus is an opportunistic pathogenic bacteria on the surface of the skin that causes impetigo. Treatment therapy for impetigo can be done by administering natural medication from papaya seeds (Carica papaya L). This study aims to determine the antibacterial activity of Staphylococcus aureus papaya seed extract based on the different types of extract solvents used. This research is true experimental research with a posttest only control design research form. The research method used was the disk diffusion method with three treatments of papaya seed extract, namely 96% ethanol extract, ethyl acetate and n-hexane, positive control using chloramphenicol and negative control using 96% ethanol, ethyl acetate and n-hexane. The research results showed that each papaya seed extract treatment was able to inhibit Staphylococcus aureus with an inhibition zone of 96% ethanol extract of 18.09 mm, ethyl acetate extract of 7.93 mm, n-hexane extract of 0.36 mm. The One Way Anova test showed a value of ρα(0.05) so that there was a significant difference in the diameter of the inhibition zone in each extract treatment. The Tukey test showed that there were significant differences in the inhibition zone of Staphylococcus aureus bacteria (ρα(0.05)) in almost all treatments. The conclusion of this research is that there is a difference in the antibacterial activity of 96% ethanol extract, ethyl acetate extract and n-hexane extract of papaya seeds on the growth of Sthaphylococcus aureus bacteria.
ASPEK KLINIS DAN LABORATORIS PENYAKIT HEPATOMA Dewi, Pande Putu Ayu Patria; Anniwati, Leonita; Bekti, Heri Setiyo
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.3811

Abstract

Hepatoma (karsinoma hepatoseluler) adalah kanker hati yang berasal dari hepatosit. Insiden hepatoma adalah 5,6 dari semua kanker yang menyerang manusia. Angka kematian dan kejadian hepatoma adalah 500.000 sampai 1 juta kasus setiap tahunnya. Faktor risiko hepatoma adalah virus hepatitis B (HBV), virus hepatitis C (HCV), sirosis hati, aflatoksin, obesitas, diabetes melitus, dan alkohol. Patogenesis hepatoma berasal dari faktor risiko dan berkembang menjadi fase kronis, infeksi yang disebabkan oleh HBV dan HCV akan menyebabkan inflamasi dan menghasilkan radikal bebas, sitokin, dan kemokin yang mengakibatkan kerusakan DNA sel, proliferasi sel, fibrosis, dan angiogenesis. Manifestasi klinis hepatoma adalah ikterus, ensefalopati hepatik, oedema anasarca, asites, dan varises. Diagnosis hepatoma ditegakkan dari anamnesis, pemeriksaan fisik, penanda tumor  seperti Alpha-1 Fetoprotein (AFP ) Lens Culinaris Agglutinin-Reactive AFP (AFP-L3) Des-g-carboxy prothrombin, Alpha-l-fucosidase (AFU), Glypican-3 (GPC3), Squamous cell carcinoma antigen (SCCA), Golgi protein 73, Hepatocyte growth factor (HGF), Transforming growth factor-beta 1 (TGF-b1), Vascular endothelial growth factor (VEGF), dan Proteomik serum serta biopsi.
Edukasi Rumah Sehat “Door To Door System” Meningkatkan Pengetahuan Sikap dan Perilaku Keluarga Penderita Tb Paru Sudiadnyana, I Wayan; Yulianti, Anysiah Elly
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.3870

Abstract

Background: Pulmonary TB disease is still a global health problem. Various prevention efforts have been made, but until now pulmonary TB disease has not been completely treated. Transmission of pulmonary TB disease is influenced by two dominant factors, namely the environment and behavior. The proposed study aims to measure the effectiveness of healthy home education "door to door system" in improving knowledge, attitudes and behavior of pulmonary TB prevention.Method: Pre-experimental research with pre and post-test design. The sample was a total population of 32 respondents of families with pulmonary TB.Result: Healthy home education can increase average knowledge before 7.8 and 14.0. Attitude before 5.5 and after 6.5. Behavior before 5.2 and after 5.8. The increase in knowledge reached 72.9%, attitude 18.3% and behavior 11.4%. Statistical tests showed that there was a difference in the average value of knowledge, attitude and behavior of preventing pulmonary TB before and after providing healthy home education, with a ρ value for knowledge: 0.000, attitude: 0.002 and behavior: 0.006.Conclusion: Healthy home education “door to door system” is quite effective to improve knowledge, attitude and behavior of families of patients in preventing pulmonary TB. The health center is advised that direct education “door to door system” be one of the alternative counseling activities to involve family participation in preventing pulmonary TB.
The Anti-Inflammatory Potential of Fermented Red Ginger Extract (Zingiber officinale var. Rubrum) Against In Vitro Protein Denaturation Kusdiharti, Meutia Sri; Dewi, Ni Wayan Rika Kumara; Artika, Made Prita
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.4093

Abstract

Background:Red ginger (Zingiber officinale var. Rubrum) is known for many phytochemical components and various pharmacological activities, such as anti-inflammation. However, red ginger also has a high cellulose level. Special treatment is needed to degrade the cellulose so that phytochemicals can be maximally extracted. Trichoderma harzianum, a cellulase enzyme-producing fungus, can degrade cellulose and increase the efficiency of phytochemical extraction. Aims:This study aimed to evaluate the in vitro anti-inflammatory potential of red ginger extract fermented with T. harzianum. Methods:This research is an experimental method involving the fermentation of red ginger powder before extraction, followed by an in vitro protein denaturation inhibition assay using a UV-Vis spectrophotometer. Bovine Serum Albumin (BSA) was used as a negative control, diclofenac sodium as a positive control, and the fermented red ginger extract (FRGE) was tested at concentrations of 25, 50, 75, 100, and 125 ppm. The results: Phytochemical screening of FRGE confirmed the presence of alkaloids, flavonoids, saponins, phenols, and triterpenoids. The extract yield was 14.29%, with the highest inhibition of protein denaturation at 62.62% observed at 125 ppm. The IC50 value is 93.61 ppm. Conclusions: Based on these research results, FRGE had strong antiinflammatory potency in vitro. Keywords: Red ginger, Fermentation, Anti-inflammatory, Protein denaturation, Trichoderma harzianum
Overview of Factors Influencing Medication Adherence in Elderly Hypertension Patients Aprianti, Pande Made Ayu; Marangyana, I Gede Bagus Indra; Sudiastini, Ni Ketut Ayu
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.4177

Abstract

Hypertension is defined as a sustained increase in blood pressure with a systolic value of ≥140 mmHg and/or a diastolic value of ≥90 mmHg. The risk of developing hypertension increases progressively with age, with a prevalence of more than 60% among individuals over 60 years old (elderly). Treatment success for hypertension depends not only on accurate diagnosis and appropriate therapy but also on patients' adherence to antihypertensive medication. This study aimed to examine the relationship between factors such as knowledge about hypertension and family support with medication adherence among elderly hypertensive patients. Methods: This was an analytical observational study with a cross-sectional design conducted at Hospital X in Denpasar. A total of 70 elderly hypertensive patients participated in the study. Data were collected using the MMAS-8 (Morisky Medication Adherence Scale) to assess medication adherence, and validated questionnaires to measure knowledge of hypertension and family support. Data analysis was performed using the Spearman correlation test. Results: A significant relationship was found between knowledge about hypertension and medication adherence (p=0.000), with a Spearman correlation coefficient of r=0.657, indicating a strong correlation. A significant relationship was also found between family support and medication adherence (p=0.000), with a correlation coefficient of r=0.546, indicating a moderate correlation. Conclusion: Higher levels of knowledge about hypertension and stronger family support are significantly associated with better medication adherence among elderly hypertensive patients. Educational efforts and family involvement are recommended to improve adherence to antihypertensive therapy.
In Silico Study of Gingerol and Shogaol from Red Ginger Rhizome (Zingiber Officinale var. rubrum) as Anti-Inflamatory Kumara Dewi, Ni Wayan Rika; Sukma Dinda, Ni Made Ayu; Suastini, Ni Made
Jurnal Skala Husada : The Journal of Health Vol 22, No 1 (2025): Jurnal Skala Husada (JSH): The Journal of Health
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jsh:tjoh.v22i1.4125

Abstract

ABSTRACTInflammation occurs when the enzyme phospholipase A2 (PLA2) releases arachidonic acid from cell membranes, leading to the production of pro-inflammatory mediators. Gingerol and shogaol are bioactive compounds with anti-inflammatory properties found in red ginger (Zingiber Officinale var. rubrum). This research aims to investigate the potential anti-inflammatory activity of gingerol and shogaol against osteoarthritis using in silico methods. The in silico tests utilized Hyperchem 8, Chimera 1.10.1, and molecular docking was performed using AutoDock Tools, supplemented with Autogrid and Autodock 4. The results of molecular docking showed hydrogen bonds and binding energy. The binding energy values for 10-gingerol were -9.01 kcal/mol, 10-shogaol -8.85 kcal/mol, 8-shogaol -8.72 kcal/mol, and 6-gingerol -8.07 kcal/mol. The results indicate that gingerol and shogaol compounds have higher binding energies compared to the target protein Phospholipase A2 (Sodium Diclofenac) at -7.57 kcal/mol. This suggests that gingerol and shogaol compounds from red ginger rhizome (Zingiber Officinale var. rubrum) have potential as anti-inflammatory agents.Keywords:  gingerol; shogaol; anti-inflammatory; phospoliphase A2; in silicoABSTRAKInflamasi atau peradangan terjadi akibat enzim phospoliphase A2 (PLA2) yang melepaskan asam arakidonat dari membran sel, sehingga menghasilkan mediator proinflamasi. Gingerol dan shogaol merupakan senyawa bioaktif yang memiliki kandungan antiinflamasi pada tanaman jahe merah (Zingiber Officinale var. rubrum). Penelitian ini bertujuan untuk mengetahui potensi aktivitas dari gingerol dan shogaol sebagai antiinflamasi terhadap penyakit osteoartritis secara in silico. Uji in silico menggunakan program Hyperchem 8, Chimera 1.10.1 dan pengujian molecular docking menggunakan program  AutoDock Tools, dilengkapai dengan program (Autogrid dan Autodock 4). Hasil pengujian molecular docking adalah ikatan hidrogen dan energi ikatan. Nilai energi ikatan pada senyawa 10-gingerol sebesar -9,01 kkal/mol, 10-shogaol sebesar -8,85 kkal/mol, 8-shogaol sebesar -8,72 kkal/mol dan 6-gingerol sebesar -8,07 kkal/mol, Hasil menyatakan bahwa senyawa gingerol dan shogaol memiliki energi ikatan yang lebih besar dibandingkan dengan protein target Phospholiphase A2 (Natrium Diclofenac) sebesar -7,57 kkal/mol. Hal ini menunjukan bahwa senyawa gingerol dan shogaol dari Rimpang Jahe Merah (Zingiber Officinale var. rubrum) berpotensi sebagai antiinflamasi.Kata kunci:gingerol; shogaol; antiinflamasi; phospoliphase A2; in silico

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