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eJournal Kedokteran Indonesia
Published by Universitas Indonesia
ISSN : 23381426     EISSN : 23386037     DOI : http://doi.org/10.23886/ejki
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
eJournal Kedokteran Indonesia (eJKI) is a general medical journal, published quadrimester (April, August, December) by Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. eJKI aims to published the manuscript of students (Bachelor of Medicine (S.Ked), study Program of Medical Profession, magister/specialist, doctoral, and fellow). The journal is a general medical journal that covering all areas of biomedical science, basic medical science, clinical science, medical technology, and medical education. The journal accepts editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. This work was supported by Faculty of Medicine, Universitas Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 162 Documents
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Pitiosis pada Manusia Yolanda, Hanna
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.945.116

Abstract

Pitiosis adalah penyakit infeksi yang disebabkan oleh oomycete Pythium insidiosum yang memiliki morfologi mirip jamur namun lebih memiliki kedekatan dengan alga. P. insidiosum secara alamiah hidup di air tawar dan tanah basah. Kontak dengan air yang terkontaminasi zoospora dan adanya trauma dapat menjadi faktor resiko utama pitiosis. Kasus pitiosis semakin banyak dilaporkan di berbagai negara di dunia, termasuk negara di Asia Tenggara. Manifestasi klinis pitiosis dapat berupa keratitis, arteritis, infeksi subkutan, dan sistemik. Pemeriksaan laboratorium untuk mendeteksi P. insidiosum dari sampel klinik sudah dikembangkan, antara lain secara mikrobiologi, histopatologi, serologi, dan molekular. Pitiosis sering terdiagnosis sebagai infeksi jamur, namun terapi dengan antijamur memiliki efikasi yang terbatas. Terapi pitiosis saat ini adalah kombinasi bedah, antibiotika, antijamur, dan/atau imunoterapi. Diagnosis dini pitiosis dapat mengarahkan klinisi pada pemberian terapi pitiosis yang sesuai dan mencegah progresifitas penyakit dan kematian.
Expression of TGF-α and TGF-β3 Proteins in the Incidence of Cleft Lip and Palate in East Nusa Tenggara Wihastyoko, Herman Yosef Limpat; Tiara, Elisa D.; Samodra, Bulan P.; Wruhastanti, Gisella S.; Inggarwati, Lulik
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.947.3

Abstract

A cleft lip (CL) is a gap in the upper lip caused by unconnected tissues before birth, often foundalongside a cleft palate (CP). In Indonesia, the prevalence of orofacial clefting is around :1,596. The incidence is multifactorial and polygenic. This study aimed to assess the expression of TGF-α andTGF-β3 proteins in endemic clefts of East Nusa Tenggara. This study used a cross-sectional method toanalyze lip epithelial tissue from patients with nonsyndromic CL/P. The research was conducted at theBioscience Laboratory, Central Laboratory of Life Sciences, and Biomedical Laboratory, UniversitasBrawijaya. This research started in April 2023 until October 2023. The study involved laboratorypreparation, paraffin block and preparate making, and immunofluorescence staining. The tissues wereinfiltrated with soft paraffin, trimmed, and thinned. The data was analyzed using Image J with athreshold of 20-100 and an independent t-test. TGF-α protein expression showed significantdifferences between East Nusa Tenggara and control, but no significant difference in TGF-β3expression. This research showed that TGF-α expression in the East Nusa Tenggara region is lowerthan control. This incidence may be due to inbreeding. Low TGF-β3 expression in patients with cleft palate only (CPO) is due to the complex development of the palate. The study reveals that low expression of TGF-α and TGF-β3 proteins in the East Nusa Tenggara region contributes to cleft lip andpalate incidence, affecting cell proliferation and palatal shelf adhesion. Keywords: Cleft lip, cleft palate, proteins, TGF-α, TGF-β3
Prevalensi dan Faktor-faktor yang Berhubungan dengan Depresi Postpartum di Kota Pontianak Ulfah, Ridha; Zakiah, Mistika; Asseggaf, Syarifah Nurul Yanti Rizki Syahab; Putri, Triyana H.
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.949.52

Abstract

Depresi Postpartum (DPP) adalah gangguan depresi non-psikotik yang dapat terjadi pada ibu postpartum dari 4 minggu setelah melahirkan hingga satu tahun. Di seluruh dunia, DPP terjadi pada hampir 17,22% ibu postpartum. Penyebab DPP mungkin bersifat fisiologis, situasional, atau multifaktorial. Penelitian ini bertujuan untuk menyetahui prevalensi dan faktor-faktor yang berhubungan dengan depresi postpartum di tiga puskesmas yang memiliki layanan rawat inap Pelayanan Persalinan Obstetri Neonatal Emergensi Dasar di wilayah Kota Pontianak. Penelitian dilakukan di Pontianak pada bulan Juni hingga Oktober 2024. Dilakukan pengukuran pada karakteristik dan depresi postpartum yang diukur dengan Edinburgh Postnatal Depression Scale. Penelitian menggunakan desain potong lintang dan data dianalisis dengan uji Chi-square. Dari 238 ibu postpartum yang termasuk ke dalam kriteria inklusi, 48,32% adalah ibu primipara, 59,24% persalinan secara sectio caesarea, dan 57,98% memberikan air susu ibu (ASI). Prevalensi depresi postpartum mencapai 27,73%. Hasil analisis bivariat didapatkan terdapat hubungan yang signifikan antara status paritas primipara (PR 1,65; 95%CI 1,07−2,51; p=0,019) dan praktek menyusui ASI (PR 1,76; 95%CI 1,17−2,66; p=0,007) terhadap gejala depresi postpartum. Tidak terdapat hubungan yang signifikan antara usia, tingkat pendidikan, pekerjaan, tingkat status ekonomi dengan kejadian DPP. Terdapat hubungan signifikan antara status paritas primipara dan praktek menyusui ASI dengan kejadian DPP.
The Relationship Between Pesticide Use and Cognitive Impairment in an Agricultural Community of Tomohon City, North Sulawesi Masengi, Angelina Stevany Regina; Mambo, Christi Diana; Nangoy, Edward; Posangi, Jimmy; Lasut, Marthen Theogives; Pertiwi, Junita Maja; Warouw, Finny; Sanggelorang, Yulianty; Sengkey, Daniel Febrian; Mamahit, Juliet Merry Eva
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.961.42

Abstract

This study investigates the cognitive effects of pesticide exposure on agricultural workers from a village in Tomohon City, North Sulawesi, Indonesia. Employing a cross-sectional design from July to September 2024. This study assessed the demographic characteristics, pesticide exposure patterns, and cognitive function of 97 participants aged 18 using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA-INA.The findings reveal a clear association between direct and indirect pesticide exposure and cognitive impairment. Direct exposure was linked to slightly lower cognitive scores than indirect exposure, with both groups scoring below established thresholds for normal cognitive function, particularly in memory, attention, and executive functions. Inconsistent use of personal protective equipment was noted among participants, with common immediate symptoms including visual disturbances and memory deficits following pesticide application. These results suggest that minimal pesticide exposure may contribute to cognitive decline, potentially accelerating age-related impairments. The underlying neurotoxic mechanisms likely involve oxidative stress, mitochondrial dysfunction, and neuroinflammation, which disrupt neuronal integrity. These findings underscore the urgent need for enhanced occupational health policies, stricter safety measures, and further research to mitigate the cognitive risks of pesticide exposure in agricultural populations.
Association between p53 Status and Breast Cancer Molecular Subtypes in the Academic Hospital of Universitas Gadjah Mada: p53 Status in Breast Carcinoma Nugrohowati, Noviana; Setyowati, Mila E.; Kusuma, Tania
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.964.59

Abstract

Breast cancer is the most common form of cancer and the leading cause of mortality in women. The p53 pathway is crucial for cell cycle regulation and tumor development. Alterations in the p53 are associated with increased aggressiveness of cancer cells. This cross-sectional study explored the association between p53 status and the molecular subtypes of invasive breast cancer in patients at the Academic Hospital of Universitas Gadjah Mada from 2016 to 2024. Immunohistochemical analysis was conducted to evaluate the presence of mutant p53 in primary tumor specimens. Of the p53-negative tumors in this study, 4 patients were triple-negative breast cancer. No association was observed between p53 expression and molecular subtype, with p-values of 0.16 and 0.224. In contrast, a significant correlation was noted between p53 and Ki67 expression, resulting in a coefficient of 0.513 (p=0.009). Additionally, a notable correlation of 0.531 was found between p53 expression and tumor size (p=0.006). In conclusion, tumor size is a crucial parameter for determining patient prognosis; specifically, as tumor size increases, p53 expression also rises, leading to a worse prognosis.
The Impact of Ramadan Fasting on Health Parameters among Elementary School Teachers in Medan Nurbaya, Siti; Yusra; Irianti Handayani, Supri; Christianta, David; Faruqi, Muhammad; Allevia Yumnanisha, Defin
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ramadan fasting, a globally significant religious practice, involves abstaining from food and drink from dawn to sunset for 29 to 30 days. While previous studies have linked fasting to various health outcomes, the results remain inconsistent. This study examines the effects of Ramadan fasting on several health indicators among elementary school teachers in Medan, focusing on body weight, glucose levels, uric acid levels, cholesterol levels, and blood pressure. Using a prospective cohort design, the study involved teachers from diverse backgrounds at Perguruan Islam Cendekia in Medan, North Sumatra. Baseline health measurements were recorded before Ramadan, with follow-up assessments conducted during and after fasting. Dietary patterns, physical activity, and other relevant factors were evaluated through validated questionnaires and interviews. Statistical analyses, including paired t-tests and Wilcoxon tests, were performed using IBM SPSS Statistics 20. Among the 20 participants, significant changes in health parameters were observed after Ramadan fasting. These included reductions in blood glucose (p = 0.034) and cholesterol levels (p = 0.014), along with an increase in uric acid levels (p = 0.009). However, no significant changes were found in BMI (p = 0.344) or mean arterial pressure (p = 0.345). These findings highlight both the benefits and potential challenges of fasting on physiological health. Ramadan fasting has a multifaceted impact on the health of elementary school teachers in Medan across different health indicators. Tailored interventions are recommended to support well-being during fasting periods.
Changes in Coping Strategies, Stress, Anxiety, and Depression among University Students Surilena, S.; Hardi, Nicholas; Suryani, Eva; Ayu, Astri Parawita; Mahaputra; Johanna, Aila; Arrang, Sherly Tandi; Vincentius, Michael; Agus, Dharmady
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The COVID-19 pandemic has changed various aspects of human life. During the early pandemic, university students must deal with academic tasks and adjust to measures to reduce the spread of COVID-19, such as online learning. This condition can be burdensome and lead to mental problems. This study aimed to identify any changes in the coping strategies and the prevalence of depression, anxiety, and stress among students during the early phase of the COVID-19 pandemic. This study used a longitudinal study design involving medical and pharmacy students of Atma Jaya Catholic University of Indonesia, Jakarta, from August 2020 to January 2021. The Brief COPE was used to assess coping mechanisms. The DASS-21 was used to evaluate stress, anxiety, and depression. The changes in coping strategies differed between medical and pharmacy students. Medical students became less self-distracted and did less planning. The pharmacy students applied behavioral disengagement more. Self-distraction and acceptance were the most common coping strategies used by both groups. While medical student participants experienced less stress, anxiety, and depression during the study period, the pharmacy students were more stressed. Most of the students experienced anxiety during the early pandemic. The present study showed some changes in coping strategies during the early phase of the COVID-19 pandemic, although self-distraction and acceptance remained the most used strategies. Additionally, anxiety is the most common mental problem experienced by the students during the COVID-19 pandemic.
Perspektif Staf Pengajar terhadap Teori dan Praktik Terbaik dalam Penerapan Flipped Classroom Vardhani, Afifah; Soemantri, Diantha
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1004.125

Abstract

Flipped classroom atau pembelajaran terbalik mengubah metode pengajaran tradisional dengan memindahkan kegiatan saat sesi tatap muka di dalam kelas menjadi kegiatan di luar kelas. Metode ini memungkinkan waktu di dalam kelas difokuskan untuk kegiatan pembelajaran interaktif yang dipandu oleh staf pengajar. Tujuan dari tinjauan pustaka ini adalah untuk menerapkan praktik terbaik dari flipped classroom berdasarkan perspektif staf pengajar. Flipped classroom merupakan proses pembelajaran dengan pendekatan konstruktivisme dan teori pembelajaran sosial. Penetapan tujuan pembelajaran, pemanfaatan teknologi, penerapan metode pembelajaran, penilaian, dan pembelajaran aktif diperlukan dalam mengatur sesi pra-kelas dan sesi tatap muka untuk mencapai flipped classroom yang efektif. Penguasaan terhadap teori dan praktik flipped classroom diperlukan untuk mencapai keberhasilan dari metode ini.
Clinical Characteristics and Outcomes of Patients with Diffuse Large B-Cell Lymphoma Treated Using R-CHOP Luhuna, Muslimah; Irawan, Cosphiadi; Harahap, Agnes S.; Shatri, Hamzah; Yunir, Em; Sutandyo, Noorwati
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma with a fairly high prevalence in Indonesia and a relatively poor prognosis. Addition of rituximab (R) to chemotherapy has led to better efficacy than other regimens in clinical trials. However, data on clinical characteristics and outcomes of patients with DLBCL are scarce. This retrospective cohort study analyzed patients' medical records of DLBCL patients from 2014 to 2021 at dr. Cipto Mangunkusumo National Hospital. Patients’ demographics, clinical characteristics, treatment responses, and 24-month event-free survival (EFS) were assessed using univariate analyses and receiver operating characteristic curves. A total of 100 patients were included, comprising 46% male and 54% female, with the majority (83%) aged <60 years. Complete response (CR) was observed in 44.2% of males and 55.8% of females, while non-complete response (non-CR) occurred in 60% and 40%, respectively. Among patients under 60 years old, CR and non-CR were 92% and 88.4%, respectively. Low and high international prognostic index (IPI) scores accounted for 58.8% and 41.2%, with corresponding CR therapy responses of 27% and 10%, and non-CR therapy responses of 52.9% and 47.1%. The majority of patients were of the non-germinal center B-cell-like (GCB) subtype (81%) compared to GCB (15%), with CR therapy responses of 84.8% and 15.2%, and non-CR therapy responses of 75% and 25%, respectively. The 24-month EFS rate was 68%. The clinical characteristics observed in this study differ from those reported in Western populations, where younger age, female gender, low IPI scores, and non-GCB subtypes were more prevalent. These findings highlight the need for further investigation to understand regional differences in DLBCL better.
Guardianship as a Risk Mitigation Strategy for Individuals with Borderline Intellectual Functioning Widiasih Raharjanti, Natalia; Sigit Ramadianto, Adhitya; Gunawan, Claudia; Krisandi, Grady; William, Dyta Ghezhanny; Reina, Natasya; Nurasty Nofara, Shafa Gendis
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1065.103

Abstract

Individuals with intellectual disabilities (ID) are vulnerable due to impairments in cognition, executivefunction, and adaptive skills. Those with borderline intellectual functioning (BIF) often go undetected dueto subtle symptoms, leaving them without proper protection. However, they remain susceptible to harmfulinfluences due to impaired analytical and decision-making abilities. This case highlights the need for in-depthfunctional assessment and guardianship as a risk mitigation strategy for individuals with BIF. A 24-year-oldwoman with developmental delays and difficulties in daily activities was brought to an adult psychiatric clinicfor guardianship assessment. Her parents were concerned as she had been repeatedly manipulated online,including an incident where she was nearly abducted. She could perform basic daily tasks but struggled withcomplex ones. Psychiatric evaluation diagnosed her with BIF (IQ=83). She lacks insight into her limitations,which makes her have poor help-seeking behavior. The psychiatric report recommended guardianship toensure her safety. A thorough assessment by a psychiatrist is needed to detect BIF among those with a historyof repeated safety incidents to ensure the protection of their safety while still respecting their rights.

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